Probabilistic Consistency-based Multiple Alignment of Amino Acid Sequences |
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About the PROBCONS projectPROBCONS is a novel tool for generating multiple alignments of protein sequences. Using a combination of probabilistic modeling and consistency-based alignment techniques, PROBCONS has achieved the highest accuracies of all alignment methods to date. On the BAliBASE benchmark alignment database, alignments produced by PROBCONS show statistically significant improvement over current programs, containing an average of 7% more correctly aligned columns than those of T-Coffee, 11% more correctly aligned columns than those of CLUSTAL W, and 14% more correctly aligned columns than those of DIALIGN. PROBCONS was developed by Chuong Do in collaboration with Michael Brudno in the research group of Serafim Batzoglou, Department of Computer Science, Stanford University. Further informationThe methods used in PROBCONS are described in the following paper: |