Module 146 -- GPCR

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General Properties
Below we list the number of gene sets from which the module was composed was originally composed, and the number of genes and experiments that it contains. Clicking on the number of genes will display a detailed list of all the genes in the module. Clicking on the number of experiments will display a detailed list of all the experiments in the module.
Num gene sets: 2
Num genes: 102 (see 2478 additional genes for this module)
Num experiments: 437 (169 induced, 268 repressed)
Parent module: None
Children modules: None


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Gene sets
Below we list the gene sets from which the module was originally composed. Clicking on a gene set will display all the genes associated with that gene set. Also listed are all the other modules in which the gene set participates.
rhodopsin_like receptor activity
G_protein coupled receptor activity


Jump to: Home | General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Enriched clinical annotations
For each of the clinical annotations, we tested whether it was enriched in the set of arrays in which the module is significantly induced (or repressed). Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of induced (or repressed) module's arrays in which they appear. We also show the fraction of the module's induced (or repressed) arrays with the given annotation ('Hits (%)' column). For completeness, we also list the total number of relevant induced arrays in the module ('Module hits in category' column), total number of arrays in the compendium in which the corresponding annotation is present ('Arrays in annotation' column), and the total number of relevant arrays in the compendium ('Arrays' column). Note that the 'relevant' arrays may be different for each annotation, since it includes only arrays in which the annotation was relevant (i.e., present or not present) and excludes arrays where the value of the annotation was not known. Rows that correspond to annotations that were enriched in the induced arrays of the module have a red background, while rows corresponding to annotations enriched in the repressed arrays have a green background. For each annotation, we also list the other modules in which it was enriched.
Clinical annotation Category P-value Hits Hits(%) Module hits in category Arrays in annotation Arrays
Liver tissue (Liver cancer*) Liver cancer* 8.9e-23 60 35.5 169 187 1945
Liver tissue, cancer or cell line (Liver cancer*) Liver cancer* 2.0e-21 60 35.5 169 197 1945
Hepatitis infected liver (Liver cancer*) Liver cancer* 7.1e-18 49 28.9 169 156 1945
Non-tumor liver tissue (Liver cancer) Liver cancer 4.9e-13 45 75 60 76 207
Invasive liver tumor (Liver cancer) Liver cancer 7.6e-11 26 52 50 38 207
Prostate (Prostate cancer*) Prostate cancer* 1.2e-10 39 14.5 268 101 1945
Cancer and cell line (Liver cancer) Liver cancer 1.7e-10 48 96 50 126 207
Hepatocellular carcinoma (Liver cancer) Liver cancer 2.2e-09 43 86 50 104 207
Hematologic samples and cell lines (B lymphoma) B lymphoma 2.8e-09 32 94.1 34 121 245
Lymphoma (B lymphoma) B lymphoma 6.4e-09 26 76.4 34 77 245
Cancer (Liver cancer) Liver cancer 3.1e-08 44 88 50 115 207
Lymphocytes (Leukemia) Leukemia 3.2e-08 38 97.4 39 91 141
Acute lymphocytic leukemia (Leukemia) Leukemia 1.5e-07 38 97.4 39 99 149
Adenocarcinoma (Liver cancer) Liver cancer 3.1e-07 39 78 50 97 207
Cell line (Breast cancer) Breast cancer 3.7e-07 15 62.5 24 30 152
Breast cancer cell line (Breast cancer) Breast cancer 1.0e-06 11 45.8 24 17 152
Hepatitis infected liver (Liver cancer*) Liver cancer* 1.5e-06 43 16.0 268 156 1945
Female hormonal cancer cell line (Breast cancer) Breast cancer 2.7e-06 10 41.6 24 15 152
Acute leukemia (Leukemia*) Leukemia* 4.7e-06 39 14.5 268 141 1945
Cancer and cell line (Leukemia*) Leukemia* 4.7e-06 39 14.5 268 141 1945
Cancer (Leukemia*) Leukemia* 4.7e-06 39 14.5 268 141 1945
Hematologic cancer and cell line (Leukemia*) Leukemia* 4.7e-06 39 14.5 268 141 1945
Hematologic cancer (Leukemia*) Leukemia* 4.7e-06 39 14.5 268 141 1945
Hematologic samples and cell lines (Leukemia*) Leukemia* 4.7e-06 39 14.5 268 141 1945
Leukemia (Leukemia*) Leukemia* 4.7e-06 39 14.5 268 141 1945
Leukemia or leukemia cell line (Leukemia*) Leukemia* 4.7e-06 39 14.5 268 141 1945
Monocytes (Leukemia*) Leukemia* 4.7e-06 39 14.5 268 141 1945
B cells (Leukemia) Leukemia 7.1e-06 29 74.3 39 62 141
Liver tissue, cancer or cell line (Liver cancer*) Liver cancer* 7.2e-06 49 18.2 268 197 1945
Liver tissue (Liver cancer*) Liver cancer* 2.0e-05 46 17.1 268 187 1945
Activated B like DLBCL (B lymphoma) B lymphoma 4.8e-05 7 63.6 11 30 245
Hematologic cancer and cell line (Stimulated PBMC) Stimulated PBMC 7.1e-05 9 60 15 30 182
Macrophages (Stimulated PBMC) Stimulated PBMC 7.1e-05 9 60 15 30 182
Bone marrow (Leukemia) Leukemia 0.0002 14 35.8 39 23 141


Jump to: Home | General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Enriched GO annotations
For each GO annotation, we tested whether it was enriched in the set of genes of the module. Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of the module's genes in which they appear. We also show the fraction of the module's genes with the given GO annotation that are included in this module ('Hits (%)' column). For completeness, we also list the total number of genes in the module ('Module genes' column), total number of genes in the compendium in which the corresponding annotation is present ('Genes in annotation' column), and the total number of genes in the compendium ('Genes' column).
GO annotation P-value Hits Hits(%) Module genes Genes in annotation Genes
G-protein coupled receptor activity 4.8e-163 102 100 102 170 4566
rhodopsin-like receptor activity 2.7e-132 89 87.2 102 147 4566
transmembrane receptor activity 1.7e-108 102 100 102 448 4566
receptor activity 1.4e-95 102 100 102 582 4566
G-protein coupled receptor protein signaling pathway 5.3e-79 76 74.5 102 245 4566
signal transducer activity 1.2e-68 102 100 102 1026 4566
conjugation without cellular fusion 1.4e-66 60 58.8 102 152 4566
peptide receptor activity\, G-protein coupled 5.3e-56 40 39.2 102 58 4566
peptide receptor activity 2.5e-55 39 38.2 102 55 4566
integral to plasma membrane 2.6e-50 79 77.4 102 612 4566
sensory perception 2.2e-31 67 65.6 102 700 4566
G-protein signaling\, coupled to cyclic nucleotide second messenger 2.8e-29 26 25.4 102 57 4566
G-protein signaling\, coupled to IP3 second messenger (phospholipase C activating) 2.8e-28 24 23.5 102 48 4566
chemosensory perception 5.0e-25 60 58.8 102 682 4566
amine receptor activity 2.8e-23 18 17.6 102 30 4566
cytosolic calcium ion concentration elevation 7.2e-22 16 15.6 102 24 4566
signal transduction 2.3e-20 60 58.8 102 831 4566
cell communication 8.8e-18 63 61.7 102 1030 4566
G-protein signaling\, coupled to cAMP nucleotide second messenger 2.8e-17 16 15.6 102 39 4566
response to abiotic stimulus 1.3e-16 67 65.6 102 1228 4566
G-protein chemoattractant receptor activity 1.3e-16 11 10.7 102 14 4566
cell surface receptor linked signal transduction 1.5e-15 31 30.3 102 259 4566
glutamate receptor activity 3.6e-15 15 14.7 102 42 4566
cAMP-mediated signaling 2.3e-14 13 12.7 102 31 4566
nucleotide receptor activity 4.3e-12 9 8.8 102 15 4566
chemokine binding 7.3e-12 8 7.8 102 11 4566
taxis 5.6e-11 15 14.7 102 76 4566
response to starvation 1.2e-10 8 7.8 102 14 4566
phosphatidylinositol-4\,5-bisphosphate hydrolysis 2.5e-10 7 6.8 102 10 4566
phospholipase C activation 2.5e-10 7 6.8 102 10 4566
feeding behavior 2.6e-10 8 7.8 102 15 4566
chemotaxis 3.8e-10 14 13.7 102 73 4566
energy taxis 4.7e-10 14 13.7 102 74 4566
secretin-like receptor activity 1.6e-09 7 6.8 102 12 4566
intracellular signaling cascade 3.1e-09 26 25.4 102 319 4566
G-protein signaling\, adenylate cyclase inhibiting pathway 2.1e-08 7 6.8 102 16 4566
phototransduction 2.5e-08 8 7.8 102 24 4566
synaptic transmission 2.6e-08 15 14.7 102 116 4566
serotonin receptor activity 2.9e-08 5 4.9 102 6 4566
activation of MAPK 8.8e-08 6 5.8 102 12 4566
adrenoceptor activity 1.0e-07 5 4.9 102 7 4566
rhodopsin mediated signaling 1.6e-07 6 5.8 102 13 4566
thermoregulation 4.0e-07 13 12.7 102 105 4566
G-protein signaling\, adenylate cyclase activating pathway 4.5e-07 6 5.8 102 15 4566
invasive growth 4.5e-07 6 5.8 102 15 4566
rhodopsin mediated phototransduction 4.5e-07 6 5.8 102 15 4566
inflammatory response 5.6e-07 13 12.7 102 108 4566
response to biotic stimulus 1.0e-06 32 31.3 102 600 4566
vesicle-mediated transport 1.0e-06 17 16.6 102 196 4566
coreceptor activity 1.1e-06 5 4.9 102 10 4566
cellular morphogenesis 2.2e-06 6 5.8 102 19 4566
endosome 2.2e-06 6 5.8 102 19 4566
neuropeptide receptor activity 3.4e-06 4 3.9 102 6 4566
prostaglandin receptor activity 3.4e-06 4 3.9 102 6 4566
MAPKKK cascade (osmolarity sensing) 4.4e-06 6 5.8 102 21 4566
adenylate cyclase activation 5.6e-06 5 4.9 102 13 4566
neuropeptide signaling pathway 5.9e-06 7 6.8 102 33 4566
vision 1.0e-05 11 10.7 102 100 4566
MAPKKK cascade 1.3e-05 6 5.8 102 25 4566
perception of light 1.4e-05 11 10.7 102 103 4566
two-component signal transduction system (phosphorelay) 1.7e-05 6 5.8 102 26 4566
acetylcholine receptor activity 2.7e-05 4 3.9 102 9 4566
circulation 2.7e-05 8 7.8 102 56 4566
negative regulation of adenylate cyclase activity 4.4e-05 4 3.9 102 10 4566
nicotinic acetylcholine-activated cation-selective channel activity 4.4e-05 4 3.9 102 10 4566
perception of mechanical stimulus 4.4e-05 4 3.9 102 10 4566
excitatory extracellular ligand-gated ion channel activity 4.5e-05 5 4.9 102 19 4566
channel/pore class transporter activity 7.1e-05 20 19.6 102 351 4566
cellular defense response 0.0001 7 6.8 102 50 4566
alpha-adrenergic receptor activity 0.0001 3 2.9 102 5 4566
G-protein coupled receptor activity\, unknown ligand 0.0001 3 2.9 102 5 4566


Jump to: Home | General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Visual display
Below is a visual display of the module. Shown are those arrays in which the module's genes significantly change, and the direction of change (induction/repression) in each array is indicated (middle, labeled 'Module changes'; red/green row). The arrays that correspond to the significant clinical attributes are also shown (top; brown rows). The gene sets that compose the module are also shown (left) along with an indication of the membership of the module genes in these gene sets.
You can also view the images within GeneXPress by loading the module gxp file file.
Note: Since there are 437 experiments, this image does not display the individual experiment names, but rather condenses each experiment to a single pixel without displaying its name. You can fully view the image for this module within GeneXPress, by loading any of the four files mentioned in the line above
 
 





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