Module 179 -- Blood cells and cancer expression clusters

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General Properties
Below we list the number of gene sets from which the module was composed was originally composed, and the number of genes and experiments that it contains. Clicking on the number of genes will display a detailed list of all the genes in the module. Clicking on the number of experiments will display a detailed list of all the experiments in the module.
Num gene sets: 12
Num genes: 476 (see 1363 additional genes for this module)
Num experiments: 464 (209 induced, 255 repressed)
Parent module: 255
Children modules: 136


Jump to: Home | General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Gene sets
Below we list the gene sets from which the module was originally composed. Clicking on a gene set will display all the genes associated with that gene set. Also listed are all the other modules in which the gene set participates.
Alizadeh00 4
Boldrick02 17
Rosenwald01 1
Alizadeh00 3
Boldrick02 27
Boldrick02 20
Rosenwald01 24
Alizadeh00 33
Boldrick02 15
Alizadeh00 40
Rosenwald01 32
Rosenwald01 18


Jump to: Home | General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Enriched clinical annotations
For each of the clinical annotations, we tested whether it was enriched in the set of arrays in which the module is significantly induced (or repressed). Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of induced (or repressed) module's arrays in which they appear. We also show the fraction of the module's induced (or repressed) arrays with the given annotation ('Hits (%)' column). For completeness, we also list the total number of relevant induced arrays in the module ('Module hits in category' column), total number of arrays in the compendium in which the corresponding annotation is present ('Arrays in annotation' column), and the total number of relevant arrays in the compendium ('Arrays' column). Note that the 'relevant' arrays may be different for each annotation, since it includes only arrays in which the annotation was relevant (i.e., present or not present) and excludes arrays where the value of the annotation was not known. Rows that correspond to annotations that were enriched in the induced arrays of the module have a red background, while rows corresponding to annotations enriched in the repressed arrays have a green background. For each annotation, we also list the other modules in which it was enriched.
Clinical annotation Category P-value Hits Hits(%) Module hits in category Arrays in annotation Arrays
Hematologic samples and cell lines (Stimulated PBMC*) Stimulated PBMC* 1.5e-60 102 48.8 209 182 1945
Monocytes (Stimulated PBMC*) Stimulated PBMC* 1.5e-60 102 48.8 209 182 1945
Hematologic samples (Stimulated PBMC*) Stimulated PBMC* 1.2e-47 84 40.1 209 152 1945
Lymphocytes (Stimulated PBMC*) Stimulated PBMC* 1.2e-47 84 40.1 209 152 1945
Primary blood mononuclear cells (Stimulated PBMC*) Stimulated PBMC* 1.2e-47 84 40.1 209 152 1945
Stimulated immune cells (Stimulated PBMC*) Stimulated PBMC* 7.0e-47 81 38.7 209 143 1945
Lymphocytes (B lymphoma*) B lymphoma* 1.8e-26 92 36.0 255 244 1945
Cancer and cell line (B lymphoma*) B lymphoma* 2.4e-22 80 31.3 255 214 1945
Hematologic cancer and cell line (B lymphoma*) B lymphoma* 2.4e-22 80 31.3 255 214 1945
B cells (B lymphoma*) B lymphoma* 6.7e-22 83 32.5 255 231 1945
Hematologic samples (Stimulated PBMC*) Stimulated PBMC* 1.1e-21 65 25.4 255 152 1945
Lymphocytes (Stimulated PBMC*) Stimulated PBMC* 1.1e-21 65 25.4 255 152 1945
Primary blood mononuclear cells (Stimulated PBMC*) Stimulated PBMC* 1.1e-21 65 25.4 255 152 1945
Hematologic samples and cell lines (Stimulated PBMC*) Stimulated PBMC* 6.4e-21 71 27.8 255 182 1945
Monocytes (Stimulated PBMC*) Stimulated PBMC* 6.4e-21 71 27.8 255 182 1945
Cancer (B lymphoma*) B lymphoma* 1.6e-19 73 28.6 255 200 1945
Hematologic cancer (B lymphoma*) B lymphoma* 1.6e-19 73 28.6 255 200 1945
Stimulated immune cells (Stimulated PBMC*) Stimulated PBMC* 4.9e-15 54 21.1 255 143 1945
B cells (B lymphoma*) B lymphoma* 6.6e-09 53 25.3 209 231 1945
Lymphocytes (B lymphoma*) B lymphoma* 5.2e-08 53 25.3 209 244 1945
Cell line (Breast cancer) Breast cancer 1.7e-06 13 65 20 30 152
Breast cancer cell line (Breast cancer) Breast cancer 2.4e-05 9 45 20 17 152
Centroblasts (Various tumors) Various tumors 4.5e-05 4 40 10 5 154
GC B like DLBCL (Various tumors) Various tumors 4.5e-05 4 40 10 5 154
Cancer (B lymphoma*) B lymphoma* 7.0e-05 39 18.6 209 200 1945
Hematologic cancer (B lymphoma*) B lymphoma* 7.0e-05 39 18.6 209 200 1945
Stimulated B cells (B lymphoma) B lymphoma 7.4e-05 9 16.9 53 12 245
Female hormonal cancer cell line (Breast cancer) Breast cancer 7.9e-05 8 40 20 15 152
Cancer and cell line (B lymphoma*) B lymphoma* 0.0001 40 19.1 209 214 1945
Hematologic cancer and cell line (B lymphoma*) B lymphoma* 0.0001 40 19.1 209 214 1945
Hematologic samples and cell lines (Various tumors) Various tumors 0.0001 8 80 10 37 154
Hematologic samples (Various tumors) Various tumors 0.0001 8 80 10 37 154
Hematologic samples (B lymphoma) B lymphoma 0.0003 12 22.6 53 22 245


Jump to: Home | General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Enriched GO annotations
For each GO annotation, we tested whether it was enriched in the set of genes of the module. Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of the module's genes in which they appear. We also show the fraction of the module's genes with the given GO annotation that are included in this module ('Hits (%)' column). For completeness, we also list the total number of genes in the module ('Module genes' column), total number of genes in the compendium in which the corresponding annotation is present ('Genes in annotation' column), and the total number of genes in the compendium ('Genes' column).
GO annotation P-value Hits Hits(%) Module genes Genes in annotation Genes
inflammatory response 7.7e-06 14 9.4 148 108 4566
thermoregulation 0.0001 12 8.1 148 105 4566


Jump to: Home | General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Visual display
Below is a visual display of the module. Shown are those arrays in which the module's genes significantly change, and the direction of change (induction/repression) in each array is indicated (middle, labeled 'Module changes'; red/green row). The arrays that correspond to the significant clinical attributes are also shown (top; brown rows). The gene sets that compose the module are also shown (left) along with an indication of the membership of the module genes in these gene sets.
You can also view the images within GeneXPress by loading the module gxp file file.
Note: Since there are 464 experiments, this image does not display the individual experiment names, but rather condenses each experiment to a single pixel without displaying its name. You can fully view the image for this module within GeneXPress, by loading any of the four files mentioned in the line above
 
 





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