Module 18

General Properties
Below we list the number of gene sets from which the module was composed was originally composed, and the number of genes and experiments that it contains. Clicking on the number of genes will display a detailed list of all the genes in the module. Clicking on the number of experiments will display a detailed list of all the experiments in the module.
Num gene sets:	2
Num genes:	451 (see 2841 additional genes for this module)
Num experiments:	970 (312 induced, 658 repressed)
Parent module:	52
Children modules:	None

Gene sets
Below we list the gene sets from which the module was originally composed. Clicking on a gene set will display all the genes associated with that gene set. Also listed are all the other modules in which the gene set participates.
A2058_2
A2058_1

Enriched clinical annotations
For each of the clinical annotations, we tested whether it was enriched in the set of arrays in which the module is significantly induced (or repressed). Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of induced (or repressed) module's arrays in which they appear. We also show the fraction of the module's induced (or repressed) arrays with the given annotation ('Hits (%)' column). For completeness, we also list the total number of relevant induced arrays in the module ('Module hits in category' column), total number of arrays in the compendium in which the corresponding annotation is present ('Arrays in annotation' column), and the total number of relevant arrays in the compendium ('Arrays' column). Note that the 'relevant' arrays may be different for each annotation, since it includes only arrays in which the annotation was relevant (i.e., present or not present) and excludes arrays where the value of the annotation was not known. Rows that correspond to annotations that were enriched in the induced arrays of the module have a red background, while rows corresponding to annotations enriched in the repressed arrays have a green background. For each annotation, we also list the other modules in which it was enriched.
Clinical annotation	Category	P-value	Hits	Hits(%)	Module hits in category	Arrays in annotation	Arrays
Hematologic cancer and cell line (Stimulated PBMC)	Stimulated PBMC	2.4e-30	30	88.2	34	30	182
Macrophages (Stimulated PBMC)	Stimulated PBMC	2.4e-30	30	88.2	34	30	182
CNS tissue, cancer or cell line (Neuro tumors*)	Neuro tumors*	2.0e-16	65	9.8	657	85	1945
Cancer and cell line (Liver cancer)	Liver cancer	2.2e-15	60	98.3	61	126	207
CNS cancer or cell line (Neuro tumors*)	Neuro tumors*	6.7e-15	61	9.2	657	81	1945
CNS tumor (Neuro tumors*)	Neuro tumors*	6.7e-15	61	9.2	657	81	1945
Cancer and cell line (Neuro tumors*)	Neuro tumors*	1.2e-13	62	9.4	657	86	1945
Cancer (Neuro tumors*)	Neuro tumors*	1.2e-13	62	9.4	657	86	1945
Prostate (Prostate cancer*)	Prostate cancer*	3.4e-13	69	10.5	657	101	1945
Chronic lymphocytic leukemia (B lymphoma)	B lymphoma	1.2e-11	37	41.5	89	46	245
Leukemia (B lymphoma)	B lymphoma	1.2e-11	37	41.5	89	46	245
Leukemia or leukemia cell line (B lymphoma)	B lymphoma	1.2e-11	37	41.5	89	46	245
Non-tumor liver tissue (Liver cancer)	Liver cancer	6.4e-10	47	65.2	72	76	207
Cell line (B lymphoma)	B lymphoma	1.6e-09	11	39.2	28	14	245
Normal lung tissue (Lung cancer)	Lung cancer	3.7e-07	19	19.5	97	22	276
Cell line (Liver cancer)	Liver cancer	7.3e-07	11	18.0	61	11	207
Hematologic cancer and cell line (Stimulated immune*)	Stimulated immune*	1.5e-06	23	7.3	312	53	1945
Hematologic samples and cell lines (Stimulated immune*)	Stimulated immune*	1.5e-06	23	7.3	312	53	1945
Macrophages (Stimulated immune*)	Stimulated immune*	1.5e-06	23	7.3	312	53	1945
Monocytes (Stimulated immune*)	Stimulated immune*	1.5e-06	23	7.3	312	53	1945
Normal tissue (Lung cancer)	Lung cancer	1.5e-06	19	19.5	97	23	276
Invasive liver tumor (Liver cancer)	Liver cancer	1.6e-06	24	39.3	61	38	207
Cancer (Liver cancer)	Liver cancer	2.0e-06	49	80.3	61	115	207
Liver tissue, cancer or cell line (Liver cancer*)	Liver cancer*	2.3e-06	56	17.9	312	197	1945
Liver cancer cell line (Liver cancer)	Liver cancer	2.8e-06	10	16.3	61	10	207
Hematologic cancer and cell line (NCI60)	NCI60	3.0e-06	13	27.0	48	14	139
Hematologic samples and cell lines (NCI60)	NCI60	3.0e-06	13	27.0	48	14	139
Leukemia cell line (NCI60)	NCI60	3.0e-06	13	27.0	48	14	139
Adenocarcinoma (Liver cancer)	Liver cancer	9.1e-06	43	70.4	61	97	207
Grade 3 (Breast cancer)	Breast cancer	2.0e-05	12	100	12	38	85
Hematologic samples (B lymphoma)	B lymphoma	5.1e-05	17	19.1	89	22	245
Follicular lymphoma (B lymphoma)	B lymphoma	6.6e-05	20	22.4	89	28	245
Melanoma cell line (NCI60)	NCI60	8.0e-05	11	32.3	34	16	139
Melanoma tumor or cell line (NCI60)	NCI60	8.0e-05	11	32.3	34	16	139
Renal tissue (Various tumors)	Various tumors	9.8e-05	10	15.6	64	10	154
B. petrussis 537 stimulated immune cells (Stimulated PBMC)	Stimulated PBMC	0.0001	5	20	25	5	144
B. petrussis A2 stimulated immune cells (Stimulated PBMC)	Stimulated PBMC	0.0001	5	20	25	5	144
B. petrussis Tox 6 stimulated immune cells (Stimulated PBMC)	Stimulated PBMC	0.0001	5	20	25	5	144
Hepatocellular carcinoma (Liver cancer)	Liver cancer	0.0001	43	70.4	61	104	207
Lymphoma or lymphoma cell line (B lymphoma)	B lymphoma	0.0001	27	96.4	28	167	245
Lung carcinoid (Lung cancer)	Lung cancer	0.0001	15	15.4	97	20	276
Large cell lung cancer (Lung cancer)	Lung cancer	0.0001	4	11.7	34	4	276
B. petrussis stimulated immune cells (Stimulated PBMC)	Stimulated PBMC	0.0002	20	80	25	67	144
Cancer and cell line (Gliomas*)	Gliomas*	0.0002	28	4.2	657	47	1945
Cancer (Gliomas*)	Gliomas*	0.0002	28	4.2	657	47	1945
CNS cancer or cell line (Gliomas*)	Gliomas*	0.0002	28	4.2	657	47	1945
CNS tissue, cancer or cell line (Gliomas*)	Gliomas*	0.0002	28	4.2	657	47	1945
CNS tumor (Gliomas*)	Gliomas*	0.0002	28	4.2	657	47	1945
Atypical teratoid/rhabdoid tumour - CNS and other origin (Neuro tumors)	Neuro tumors	0.0002	6	50	12	10	90
Follicular lymphoma (Various tumors)	Various tumors	0.0002	9	14.0	64	9	154
Breast cancer cell line (Breast cancer)	Breast cancer	0.0003	9	34.6	26	17	152

Enriched GO annotations
For each GO annotation, we tested whether it was enriched in the set of genes of the module. Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of the module's genes in which they appear. We also show the fraction of the module's genes with the given GO annotation that are included in this module ('Hits (%)' column). For completeness, we also list the total number of genes in the module ('Module genes' column), total number of genes in the compendium in which the corresponding annotation is present ('Genes in annotation' column), and the total number of genes in the compendium ('Genes' column).
GO annotation	P-value	Hits	Hits(%)	Module genes	Genes in annotation	Genes
DNA replication	5.3e-06	14	4.5	309	52	4566
DNA dependent DNA replication	1.0e-05	10	3.2	309	29	4566
mitosis	1.7e-05	13	4.2	309	50	4566
S phase of mitotic cell cycle	2.9e-05	9	2.9	309	26	4566
nucleus	4.6e-05	94	30.4	309	966	4566
DNA metabolism	5.2e-05	26	8.4	309	169	4566
DNA replication and chromosome cycle	7.9e-05	9	2.9	309	29	4566
endomembrane system	0.0001	97	31.3	309	1029	4566

Visual display

Below is a visual display of the module. Shown are those arrays in which the module's genes significantly change, and the direction of change (induction/repression) in each array is indicated (middle, labeled 'Module changes'; red/green row). The arrays that correspond to the significant clinical attributes are also shown (top; brown rows). The gene sets that compose the module are also shown (left) along with an indication of the membership of the module genes in these gene sets.

You can also view the images within GeneXPress by loading the module gxp file file.

Note: Since there are 970 experiments, this image does not display the individual experiment names, but rather condenses each experiment to a single pixel without displaying its name. You can fully view the image for this module within GeneXPress, by loading any of the four files mentioned in the line above

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