Module 24 -- Fetal liver genes - Metabolism and xenobiotics

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General Properties
Below we list the number of gene sets from which the module was composed was originally composed, and the number of genes and experiments that it contains. Clicking on the number of genes will display a detailed list of all the genes in the module. Clicking on the number of experiments will display a detailed list of all the experiments in the module.
Num gene sets: 2
Num genes: 453 (see 3218 additional genes for this module)
Num experiments: 1221 (335 induced, 886 repressed)
Parent module: 55
Children modules: None


Jump to: Home | General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Gene sets
Below we list the gene sets from which the module was originally composed. Clicking on a gene set will display all the genes associated with that gene set. Also listed are all the other modules in which the gene set participates.
Fetal_liver_2
Fetal_liver_1


Jump to: Home | General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Enriched clinical annotations
For each of the clinical annotations, we tested whether it was enriched in the set of arrays in which the module is significantly induced (or repressed). Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of induced (or repressed) module's arrays in which they appear. We also show the fraction of the module's induced (or repressed) arrays with the given annotation ('Hits (%)' column). For completeness, we also list the total number of relevant induced arrays in the module ('Module hits in category' column), total number of arrays in the compendium in which the corresponding annotation is present ('Arrays in annotation' column), and the total number of relevant arrays in the compendium ('Arrays' column). Note that the 'relevant' arrays may be different for each annotation, since it includes only arrays in which the annotation was relevant (i.e., present or not present) and excludes arrays where the value of the annotation was not known. Rows that correspond to annotations that were enriched in the induced arrays of the module have a red background, while rows corresponding to annotations enriched in the repressed arrays have a green background. For each annotation, we also list the other modules in which it was enriched.
Clinical annotation Category P-value Hits Hits(%) Module hits in category Arrays in annotation Arrays
Liver tissue (Liver cancer*) Liver cancer* 5.5e-59 125 37.3 335 187 1945
Liver tissue, cancer or cell line (Liver cancer*) Liver cancer* 5.6e-55 125 37.3 335 197 1945
Hepatitis infected liver (Liver cancer*) Liver cancer* 2.2e-42 99 29.5 335 156 1945
Lung tissue, cancer or cell line (Lung cancer*) Lung cancer* 1.4e-34 218 24.6 885 276 1945
Cancer and cell line (Lung cancer*) Lung cancer* 9.3e-33 201 22.7 885 252 1945
Cancer (Lung cancer*) Lung cancer* 9.3e-33 201 22.7 885 252 1945
Lung cancer (Lung cancer*) Lung cancer* 2.0e-29 188 21.2 885 238 1945
Lung cancer or cell line (Lung cancer*) Lung cancer* 2.0e-29 188 21.2 885 238 1945
Non small cell lung cancer and cell line (Lung cancer*) Lung cancer* 1.2e-26 164 18.5 885 205 1945
Non small cell lung cancer (Lung cancer*) Lung cancer* 1.2e-26 164 18.5 885 205 1945
Non-tumor liver tissue (Liver cancer) Liver cancer 2.8e-21 75 60 125 76 207
Cancer and cell line (Liver cancer) Liver cancer 5.8e-21 71 100 71 126 207
Acute lymphocytic leukemia (Leukemia) Leukemia 1.6e-15 82 91.1 90 99 149
Prostate (Prostate cancer*) Prostate cancer* 7.5e-15 83 9.3 885 101 1945
Lymphocytes (Leukemia) Leukemia 2.2e-14 74 90.2 82 91 141
Cancer (Liver cancer) Liver cancer 5.3e-11 61 85.9 71 115 207
Cancer and cell line (Various tumors*) Various tumors* 2.6e-09 77 8.7 885 105 1945
Cancer (Various tumors*) Various tumors* 2.6e-09 77 8.7 885 105 1945
B cells (Leukemia) Leukemia 2.3e-08 52 63.4 82 62 141
Adenocarcinoma (Liver cancer) Liver cancer 3.1e-08 52 73.2 71 97 207
Breast tissue or cancer (Breast cancer*) Breast cancer* 1.7e-07 43 12.8 335 118 1945
Female hormonal tissue or cancer (Breast cancer*) Breast cancer* 1.7e-07 43 12.8 335 118 1945
Hematologic samples and cell lines (Various tumors) Various tumors 1.9e-07 36 36 100 37 154
Hematologic samples (Various tumors) Various tumors 1.9e-07 36 36 100 37 154
Cell line (NCI60*) NCI60* 5.9e-07 89 10.0 885 135 1945
Invasive liver tumor (Liver cancer) Liver cancer 2.0e-06 26 36.6 71 38 207
Cancer and cell line (NCI60*) NCI60* 2.5e-06 89 10.0 885 138 1945
Adenocarcinoma (Breast cancer*) Breast cancer* 2.6e-06 39 11.6 335 112 1945
Breast cancer (Breast cancer*) Breast cancer* 2.6e-06 39 11.6 335 112 1945
Cancer (Breast cancer*) Breast cancer* 2.6e-06 39 11.6 335 112 1945
Female hormonal cancer (Breast cancer*) Breast cancer* 2.6e-06 39 11.6 335 112 1945
Cell line (Breast cancer) Breast cancer 4.3e-06 19 45.2 42 30 152
CNS tissue, cancer or cell line (Neuro tumors*) Neuro tumors* 4.6e-06 59 6.6 885 85 1945
Hematologic cancer and cell line (Various tumors) Various tumors 5.3e-06 30 30 100 31 154
Hematologic cancer (Various tumors) Various tumors 5.3e-06 30 30 100 31 154
Primary blood mononuclear cells (Various tumors) Various tumors 5.3e-06 30 30 100 31 154
Hepatocellular carcinoma (Liver cancer) Liver cancer 5.6e-06 51 71.8 71 104 207
Diffuse large B cell lymphoma - DLBCL (B lymphoma) B lymphoma 7.1e-06 23 92 25 126 245
CNS cancer or cell line (Neuro tumors*) Neuro tumors* 9.9e-06 56 6.3 885 81 1945
CNS tumor (Neuro tumors*) Neuro tumors* 9.9e-06 56 6.3 885 81 1945
Breast cancer cell line (Breast cancer) Breast cancer 1.1e-05 13 30.9 42 17 152
Liver cancer cell line (Liver cancer) Liver cancer 1.4e-05 10 14.0 71 10 207
Metastasis (Liver cancer) Liver cancer 1.4e-05 10 14.0 71 10 207
Female hormonal tissue, cancer or cell line (Breast cancer*) Breast cancer* 1.6e-05 44 13.1 335 141 1945
Breast tissue, cancer or cell line (Breast cancer*) Breast cancer* 2.0e-05 44 13.1 335 142 1945
Activated B like DLBCL (B lymphoma) B lymphoma 2.1e-05 11 44 25 30 245
Cancer and cell line (Neuro tumors*) Neuro tumors* 2.2e-05 58 6.5 885 86 1945
Cancer (Neuro tumors*) Neuro tumors* 2.2e-05 58 6.5 885 86 1945
Lymphocytes (Various tumors) Various tumors 2.5e-05 27 27 100 28 154
Monocytes (Various tumors) Various tumors 2.5e-05 27 27 100 28 154
Diffuse large B cell lymphoma tumor or cell line (B lymphoma) B lymphoma 2.9e-05 23 92 25 134 245
CNS tissue, cancer or cell line (Various tumors) Various tumors 5.0e-05 21 21 100 21 154
Female hormonal cancer or cell line (Breast cancer*) Breast cancer* 7.8e-05 39 11.6 335 127 1945
Breast cancer or cell line (Breast cancer*) Breast cancer* 9.4e-05 39 11.6 335 128 1945
Cell line (Liver cancer) Liver cancer 0.0001 10 14.0 71 11 207
Female hormonal cancer cell line (Breast cancer) Breast cancer 0.0001 11 26.1 42 15 152
Bone marrow (Leukemia) Leukemia 0.0002 21 25.6 82 23 141
Chronic lymphocytic leukemia (B lymphoma) B lymphoma 0.0002 23 34.3 67 46 245
Leukemia (B lymphoma) B lymphoma 0.0002 23 34.3 67 46 245
Leukemia or leukemia cell line (B lymphoma) B lymphoma 0.0002 23 34.3 67 46 245
B cells (Various tumors) Various tumors 0.0002 22 22 100 23 154


Jump to: Home | General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Enriched GO annotations
For each GO annotation, we tested whether it was enriched in the set of genes of the module. Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of the module's genes in which they appear. We also show the fraction of the module's genes with the given GO annotation that are included in this module ('Hits (%)' column). For completeness, we also list the total number of genes in the module ('Module genes' column), total number of genes in the compendium in which the corresponding annotation is present ('Genes in annotation' column), and the total number of genes in the compendium ('Genes' column).
GO annotation P-value Hits Hits(%) Module genes Genes in annotation Genes
plasma protein 5.5e-13 16 4.7 335 25 4566
endopeptidase inhibitor activity 9.1e-08 19 5.6 335 65 4566
extracellular space 1.2e-07 38 11.3 335 212 4566
complement activation 8.0e-07 11 3.2 335 26 4566
plasma glycoprotein 3.0e-06 10 2.9 335 24 4566
serine protease inhibitor activity 3.7e-06 13 3.8 335 41 4566
regulation of complement activation 4.7e-06 10 2.9 335 25 4566
blood coagulation 4.8e-06 14 4.1 335 48 4566
chymotrypsin activity 4.8e-06 14 4.1 335 48 4566
serine-type endopeptidase activity 6.0e-06 17 5.0 335 69 4566
hemostasis 8.2e-06 14 4.1 335 50 4566
trypsin activity 8.2e-06 14 4.1 335 50 4566
oxidoreductase activity\, acting on paired donors\, with incorporation or reduction of molecular oxygen\, reduced flavin or flavoprotein as one donor\, and incorporation of one atom of oxygen 1.0e-05 6 1.7 335 9 4566
heparin binding 1.7e-05 12 3.5 335 40 4566
complement activity 1.7e-05 8 2.3 335 18 4566
blood coagulation factor activity 2.4e-05 6 1.7 335 10 4566
response to chemical substance 4.3e-05 42 12.5 335 308 4566
glycosaminoglycan binding 4.9e-05 12 3.5 335 44 4566
enzyme inhibitor activity 5.6e-05 20 5.9 335 105 4566
oxidoreductase activity 7.1e-05 36 10.7 335 254 4566
complement activation\, classical pathway 9.9e-05 8 2.3 335 22 4566
lipid transport 0.0001 9 2.6 335 28 4566


Jump to: Home | General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Visual display
Below is a visual display of the module. Shown are those arrays in which the module's genes significantly change, and the direction of change (induction/repression) in each array is indicated (middle, labeled 'Module changes'; red/green row). The arrays that correspond to the significant clinical attributes are also shown (top; brown rows). The gene sets that compose the module are also shown (left) along with an indication of the membership of the module genes in these gene sets.
You can also view the images within GeneXPress by loading the module gxp file file.
Note: Since there are 1221 experiments, this image does not display the individual experiment names, but rather condenses each experiment to a single pixel without displaying its name. You can fully view the image for this module within GeneXPress, by loading any of the four files mentioned in the line above
 
 





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