Module 259 -- RTK signaling

Jump to: Home | General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
General Properties
Below we list the number of gene sets from which the module was composed was originally composed, and the number of genes and experiments that it contains. Clicking on the number of genes will display a detailed list of all the genes in the module. Clicking on the number of experiments will display a detailed list of all the experiments in the module.
Num gene sets: 8
Num genes: 46 (see 1453 additional genes for this module)
Num experiments: 436 (142 induced, 294 repressed)
Parent module: None
Children modules: 199 200


Jump to: Home | General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Gene sets
Below we list the gene sets from which the module was originally composed. Clicking on a gene set will display all the genes associated with that gene set. Also listed are all the other modules in which the gene set participates.
transmembrane receptor protein tyrosine kinase activity
transmembrane receptor protein kinase activity
protein kinase activity
transmembrane receptor protein tyrosine kinase signaling pathway
post_embryonic morphogenesis
post_embryonic development
eye photoreceptor cell fate commitment
compound eye morphogenesis (sensu Drosophila)


Jump to: Home | General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Enriched clinical annotations
For each of the clinical annotations, we tested whether it was enriched in the set of arrays in which the module is significantly induced (or repressed). Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of induced (or repressed) module's arrays in which they appear. We also show the fraction of the module's induced (or repressed) arrays with the given annotation ('Hits (%)' column). For completeness, we also list the total number of relevant induced arrays in the module ('Module hits in category' column), total number of arrays in the compendium in which the corresponding annotation is present ('Arrays in annotation' column), and the total number of relevant arrays in the compendium ('Arrays' column). Note that the 'relevant' arrays may be different for each annotation, since it includes only arrays in which the annotation was relevant (i.e., present or not present) and excludes arrays where the value of the annotation was not known. Rows that correspond to annotations that were enriched in the induced arrays of the module have a red background, while rows corresponding to annotations enriched in the repressed arrays have a green background. For each annotation, we also list the other modules in which it was enriched.
Clinical annotation Category P-value Hits Hits(%) Module hits in category Arrays in annotation Arrays
Acute leukemia (Leukemia*) Leukemia* 5.2e-21 66 22.5 293 141 1945
Cancer and cell line (Leukemia*) Leukemia* 5.2e-21 66 22.5 293 141 1945
Cancer (Leukemia*) Leukemia* 5.2e-21 66 22.5 293 141 1945
Hematologic cancer and cell line (Leukemia*) Leukemia* 5.2e-21 66 22.5 293 141 1945
Hematologic cancer (Leukemia*) Leukemia* 5.2e-21 66 22.5 293 141 1945
Hematologic samples and cell lines (Leukemia*) Leukemia* 5.2e-21 66 22.5 293 141 1945
Leukemia (Leukemia*) Leukemia* 5.2e-21 66 22.5 293 141 1945
Leukemia or leukemia cell line (Leukemia*) Leukemia* 5.2e-21 66 22.5 293 141 1945
Monocytes (Leukemia*) Leukemia* 5.2e-21 66 22.5 293 141 1945
Liver tissue (Liver cancer*) Liver cancer* 5.9e-14 44 30.9 142 187 1945
Liver tissue, cancer or cell line (Liver cancer*) Liver cancer* 4.5e-13 44 30.9 142 197 1945
Cancer and cell line (Liver cancer) Liver cancer 5.3e-13 48 100 48 126 207
Cell line (Breast cancer) Breast cancer 1.8e-11 18 78.2 23 30 152
Hepatitis infected liver (Liver cancer*) Liver cancer* 1.9e-10 35 24.6 142 156 1945
Non-tumor liver tissue (Liver cancer) Liver cancer 2.0e-09 34 75.5 45 76 207
Breast cancer cell line (Breast cancer) Breast cancer 2.8e-08 12 52.1 23 17 152
Liver cancer cell line (Liver cancer) Liver cancer 2.0e-07 10 20.8 48 10 207
B cells (Leukemia) Leukemia 3.0e-07 44 66.6 66 62 141
Lung cancer (Lung cancer*) Lung cancer* 1.5e-06 62 21.1 293 238 1945
Lung cancer or cell line (Lung cancer*) Lung cancer* 1.5e-06 62 21.1 293 238 1945
Female hormonal cancer cell line (Breast cancer) Breast cancer 1.6e-06 10 43.4 23 15 152
Cell line (Liver cancer) Liver cancer 1.8e-06 10 20.8 48 11 207
Activated B like DLBCL (B lymphoma) B lymphoma 2.4e-06 9 64.2 14 30 245
Hematologic samples and cell lines (Various tumors) Various tumors 5.0e-06 15 65.2 23 37 154
Hematologic samples (Various tumors) Various tumors 5.0e-06 15 65.2 23 37 154
Cancer and cell line (Lung cancer*) Lung cancer* 6.0e-06 63 21.5 293 252 1945
Cancer (Lung cancer*) Lung cancer* 6.0e-06 63 21.5 293 252 1945
Primary blood mononuclear cells (Leukemia) Leukemia 9.2e-06 19 28.7 66 21 141
Squamous cell lung cancer (Lung cancer) Lung cancer 6.5e-05 18 28.5 63 35 276
Cancer (Liver cancer) Liver cancer 0.0001 38 79.1 48 115 207
Adenocarcinoma (Liver cancer) Liver cancer 0.0001 34 70.8 48 97 207
Lung tissue, cancer or cell line (Lung cancer*) Lung cancer* 0.0001 63 21.5 293 276 1945
Bone marrow (Leukemia) Leukemia 0.0001 19 28.7 66 23 141
Lung carcinoid (Lung cancer) Lung cancer 0.0002 12 19.0 63 20 276
Hematologic cancer and cell line (NCI60) NCI60 0.0002 9 31.0 29 14 139
Hematologic samples and cell lines (NCI60) NCI60 0.0002 9 31.0 29 14 139
Leukemia cell line (NCI60) NCI60 0.0002 9 31.0 29 14 139
Normal female hormonal tissue and cells (Various tumors) Various tumors 0.0003 3 75 4 8 154
Normal female hormonal tissue (Various tumors) Various tumors 0.0003 3 75 4 8 154


Jump to: Home | General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Enriched GO annotations
For each GO annotation, we tested whether it was enriched in the set of genes of the module. Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of the module's genes in which they appear. We also show the fraction of the module's genes with the given GO annotation that are included in this module ('Hits (%)' column). For completeness, we also list the total number of genes in the module ('Module genes' column), total number of genes in the compendium in which the corresponding annotation is present ('Genes in annotation' column), and the total number of genes in the compendium ('Genes' column).
GO annotation P-value Hits Hits(%) Module genes Genes in annotation Genes
protein kinase activity 7.7e-82 46 100 46 102 4566
transmembrane receptor protein tyrosine kinase activity 1.2e-69 38 82.6 46 62 4566
transmembrane receptor protein kinase activity 2.3e-67 38 82.6 46 68 4566
transmembrane receptor activity 8.4e-39 42 91.3 46 448 4566
protein tyrosine kinase activity 5.0e-36 29 63.0 46 120 4566
receptor activity 7.0e-34 42 91.3 46 582 4566
porin activity 9.2e-32 32 69.5 46 235 4566
signal transducer activity 6.7e-31 46 100 46 1026 4566
channel/pore class transporter activity 5.1e-26 32 69.5 46 351 4566
protein amino acid phosphorylation 3.6e-24 27 58.6 46 230 4566
response to DNA damage stimulus 5.5e-22 28 60.8 46 310 4566
response to stress 7.8e-21 37 80.4 46 792 4566
transmembrane receptor protein tyrosine kinase signaling pathway 3.0e-19 15 32.6 46 52 4566
eye photoreceptor cell fate commitment 7.8e-18 13 28.2 46 38 4566
compound eye morphogenesis (sensu Drosophila) 2.5e-17 13 28.2 46 41 4566
post-embryonic morphogenesis 2.5e-17 13 28.2 46 41 4566
hematopoietin/interferon-class (D200-domain) cytokine receptor activity 3.6e-17 13 28.2 46 42 4566
post-embryonic development 3.6e-17 13 28.2 46 42 4566
ATP binding 1.5e-16 26 56.5 46 399 4566
nucleotidyltransferase activity 7.2e-16 26 56.5 46 425 4566
signal transduction 2.0e-12 30 65.2 46 831 4566
ephrin receptor activity 2.0e-12 7 15.2 46 11 4566
integral to plasma membrane 4.2e-11 25 54.3 46 612 4566
response to extracellular stimulus 3.0e-10 22 47.8 46 500 4566
cell communication 6.1e-10 30 65.2 46 1030 4566
interleukin binding 2.7e-09 7 15.2 46 25 4566
interleukin receptor activity 6.6e-09 7 15.2 46 28 4566
morphogenesis 1.3e-06 15 32.6 46 366 4566
development 2.6e-06 18 39.1 46 554 4566


Jump to: Home | General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Visual display
Below is a visual display of the module. Shown are those arrays in which the module's genes significantly change, and the direction of change (induction/repression) in each array is indicated (middle, labeled 'Module changes'; red/green row). The arrays that correspond to the significant clinical attributes are also shown (top; brown rows). The gene sets that compose the module are also shown (left) along with an indication of the membership of the module genes in these gene sets.
You can also view the images within GeneXPress by loading the module gxp file file.
Note: Since there are 436 experiments, this image does not display the individual experiment names, but rather condenses each experiment to a single pixel without displaying its name. You can fully view the image for this module within GeneXPress, by loading any of the four files mentioned in the line above
 
 





 >4x