Module 278 -- Ubiquitin ligases

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General Properties
Below we list the number of gene sets from which the module was composed was originally composed, and the number of genes and experiments that it contains. Clicking on the number of genes will display a detailed list of all the genes in the module. Clicking on the number of experiments will display a detailed list of all the experiments in the module.
Num gene sets: 3
Num genes: 34 (see 1140 additional genes for this module)
Num experiments: 114 (50 induced, 64 repressed)
Parent module: None
Children modules: 233


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Gene sets
Below we list the gene sets from which the module was originally composed. Clicking on a gene set will display all the genes associated with that gene set. Also listed are all the other modules in which the gene set participates.
protein phosphatase type 2A activity
acid_D_amino acid ligase activity
ligase activity, forming carbon_nitrogen bonds


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Enriched clinical annotations
For each of the clinical annotations, we tested whether it was enriched in the set of arrays in which the module is significantly induced (or repressed). Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of induced (or repressed) module's arrays in which they appear. We also show the fraction of the module's induced (or repressed) arrays with the given annotation ('Hits (%)' column). For completeness, we also list the total number of relevant induced arrays in the module ('Module hits in category' column), total number of arrays in the compendium in which the corresponding annotation is present ('Arrays in annotation' column), and the total number of relevant arrays in the compendium ('Arrays' column). Note that the 'relevant' arrays may be different for each annotation, since it includes only arrays in which the annotation was relevant (i.e., present or not present) and excludes arrays where the value of the annotation was not known. Rows that correspond to annotations that were enriched in the induced arrays of the module have a red background, while rows corresponding to annotations enriched in the repressed arrays have a green background. For each annotation, we also list the other modules in which it was enriched.
Clinical annotation Category P-value Hits Hits(%) Module hits in category Arrays in annotation Arrays
Normal lung tissue (Lung cancer) Lung cancer 8.2e-14 15 62.5 24 22 276
Normal tissue (Lung cancer) Lung cancer 2.3e-13 15 62.5 24 23 276
Lung tissue, cancer or cell line (Lung cancer*) Lung cancer* 2.0e-06 24 37.5 64 276 1945
Lymphoma (B lymphoma) B lymphoma 6.1e-06 10 100 10 77 245
Mesenchemal cell line (Breast cancer) Breast cancer 2.7e-05 3 75 4 4 152
Hematologic cancer and cell line (Stimulated PBMC) Stimulated PBMC 9.0e-05 5 100 5 30 182
Macrophages (Stimulated PBMC) Stimulated PBMC 9.0e-05 5 100 5 30 182
Hematologic cancer and cell line (Stimulated immune*) Stimulated immune* 0.0002 8 12.5 64 53 1945
Hematologic samples and cell lines (Stimulated immune*) Stimulated immune* 0.0002 8 12.5 64 53 1945
Macrophages (Stimulated immune*) Stimulated immune* 0.0002 8 12.5 64 53 1945
Monocytes (Stimulated immune*) Stimulated immune* 0.0002 8 12.5 64 53 1945


Jump to: Home | General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Enriched GO annotations
For each GO annotation, we tested whether it was enriched in the set of genes of the module. Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of the module's genes in which they appear. We also show the fraction of the module's genes with the given GO annotation that are included in this module ('Hits (%)' column). For completeness, we also list the total number of genes in the module ('Module genes' column), total number of genes in the compendium in which the corresponding annotation is present ('Genes in annotation' column), and the total number of genes in the compendium ('Genes' column).
GO annotation P-value Hits Hits(%) Module genes Genes in annotation Genes
ligase activity\, forming carbon-nitrogen bonds 6.1e-74 34 100 34 50 4566
acid-D-amino acid ligase activity 4.8e-49 24 70.5 34 33 4566
ubiquitin-protein ligase activity 5.1e-41 20 58.8 34 26 4566
ubiquitin cycle 2.9e-35 18 52.9 34 26 4566
sulfur amino acid metabolism 5.1e-31 22 64.7 34 88 4566
amino acid metabolism 5.3e-30 24 70.5 34 139 4566
ubiquitin conjugating enzyme activity 4.0e-28 15 44.1 34 24 4566
small protein conjugating enzyme activity 9.9e-28 15 44.1 34 25 4566
sulfur metabolism 1.0e-25 24 70.5 34 205 4566
protein modification 3.9e-21 23 67.6 34 271 4566
catalytic activity 1.3e-15 34 100 34 1677 4566
ribonucleotide biosynthesis 1.0e-10 7 20.5 34 22 4566
ribonucleotide metabolism 1.1e-09 7 20.5 34 30 4566
other carbon-nitrogen ligase activity 2.0e-09 5 14.7 34 9 4566
nucleotide biosynthesis 7.0e-09 7 20.5 34 38 4566
purine nucleotide biosynthesis 1.2e-08 4 11.7 34 5 4566
nucleobase metabolism 8.8e-08 4 11.7 34 7 4566
nucleotide metabolism 3.0e-07 7 20.5 34 64 4566
heterocycle metabolism 5.2e-07 4 11.7 34 10 4566
ribonucleoside monophosphate biosynthesis 1.2e-06 4 11.7 34 12 4566
coenzyme metabolism 3.7e-06 3 8.8 34 5 4566
glutamine metabolism 7.4e-06 3 8.8 34 6 4566
protein processing 7.4e-06 3 8.8 34 6 4566
purine nucleoside monophosphate biosynthesis 1.2e-05 3 8.8 34 7 4566
purine ribonucleoside monophosphate metabolism 1.2e-05 3 8.8 34 7 4566
cysteine metabolism 2.0e-05 3 8.8 34 8 4566
aromatic compound metabolism 2.9e-05 4 11.7 34 25 4566
purine ribonucleoside monophosphate biosynthesis 3.0e-05 3 8.8 34 9 4566
ribonucleoside monophosphate metabolism 4.3e-05 3 8.8 34 10 4566
nucleoside monophosphate biosynthesis 5.9e-05 3 8.8 34 11 4566
purine ribonucleotide biosynthesis 7.9e-05 3 8.8 34 12 4566


Jump to: Home | General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Visual display
Below is a visual display of the module. Shown are those arrays in which the module's genes significantly change, and the direction of change (induction/repression) in each array is indicated (middle, labeled 'Module changes'; red/green row). The arrays that correspond to the significant clinical attributes are also shown (top; brown rows). The gene sets that compose the module are also shown (left) along with an indication of the membership of the module genes in these gene sets.
You can also view the images within GeneXPress by loading the module gxp file file.
 
 





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