Module 289

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General Properties
Below we list the number of gene sets from which the module was composed was originally composed, and the number of genes and experiments that it contains. Clicking on the number of genes will display a detailed list of all the genes in the module. Clicking on the number of experiments will display a detailed list of all the experiments in the module.
Num gene sets: 2
Num genes: 124 (see 2131 additional genes for this module)
Num experiments: 593 (177 induced, 416 repressed)
Parent module: 375
Children modules: None


Jump to: Home | General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Gene sets
Below we list the gene sets from which the module was originally composed. Clicking on a gene set will display all the genes associated with that gene set. Also listed are all the other modules in which the gene set participates.
conjugation without cellular fusion
G_protein coupled receptor protein signaling pathway


Jump to: Home | General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Enriched clinical annotations
For each of the clinical annotations, we tested whether it was enriched in the set of arrays in which the module is significantly induced (or repressed). Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of induced (or repressed) module's arrays in which they appear. We also show the fraction of the module's induced (or repressed) arrays with the given annotation ('Hits (%)' column). For completeness, we also list the total number of relevant induced arrays in the module ('Module hits in category' column), total number of arrays in the compendium in which the corresponding annotation is present ('Arrays in annotation' column), and the total number of relevant arrays in the compendium ('Arrays' column). Note that the 'relevant' arrays may be different for each annotation, since it includes only arrays in which the annotation was relevant (i.e., present or not present) and excludes arrays where the value of the annotation was not known. Rows that correspond to annotations that were enriched in the induced arrays of the module have a red background, while rows corresponding to annotations enriched in the repressed arrays have a green background. For each annotation, we also list the other modules in which it was enriched.
Clinical annotation Category P-value Hits Hits(%) Module hits in category Arrays in annotation Arrays
Liver tissue (Liver cancer*) Liver cancer* 6.2e-20 58 32.7 177 187 1945
Liver tissue, cancer or cell line (Liver cancer*) Liver cancer* 1.1e-18 58 32.7 177 197 1945
Hepatitis infected liver (Liver cancer*) Liver cancer* 1.6e-18 51 28.8 177 156 1945
Acute leukemia (Leukemia*) Leukemia* 2.2e-17 74 17.7 416 141 1945
Cancer and cell line (Leukemia*) Leukemia* 2.2e-17 74 17.7 416 141 1945
Cancer (Leukemia*) Leukemia* 2.2e-17 74 17.7 416 141 1945
Hematologic cancer and cell line (Leukemia*) Leukemia* 2.2e-17 74 17.7 416 141 1945
Hematologic cancer (Leukemia*) Leukemia* 2.2e-17 74 17.7 416 141 1945
Hematologic samples and cell lines (Leukemia*) Leukemia* 2.2e-17 74 17.7 416 141 1945
Leukemia (Leukemia*) Leukemia* 2.2e-17 74 17.7 416 141 1945
Leukemia or leukemia cell line (Leukemia*) Leukemia* 2.2e-17 74 17.7 416 141 1945
Monocytes (Leukemia*) Leukemia* 2.2e-17 74 17.7 416 141 1945
Cancer and cell line (Various tumors*) Various tumors* 2.5e-14 57 13.7 416 105 1945
Cancer (Various tumors*) Various tumors* 2.5e-14 57 13.7 416 105 1945
Hematologic cancer and cell line (Stimulated PBMC) Stimulated PBMC 6.1e-14 19 79.1 24 30 182
Macrophages (Stimulated PBMC) Stimulated PBMC 6.1e-14 19 79.1 24 30 182
Hematologic samples and cell lines (B lymphoma) B lymphoma 1.7e-13 58 86.5 67 121 245
Lymphoma (B lymphoma) B lymphoma 6.4e-13 45 67.1 67 77 245
Non-tumor liver tissue (Liver cancer) Liver cancer 5.8e-12 43 74.1 58 76 207
Acute lymphocytic leukemia (Leukemia) Leukemia 7.1e-10 72 87.8 82 99 149
Cancer and cell line (Liver cancer) Liver cancer 7.2e-10 42 97.6 43 126 207
Lymphocytes (Leukemia) Leukemia 7.0e-09 64 86.4 74 91 141
Activated B like DLBCL (B lymphoma) B lymphoma 8.0e-08 12 60 20 30 245
Adenocarcinoma (Liver cancer) Liver cancer 2.3e-07 35 81.3 43 97 207
Cancer (Liver cancer) Liver cancer 3.6e-07 38 88.3 43 115 207
Cell line (Breast cancer) Breast cancer 1.7e-06 15 57.6 26 30 152
B cells (Leukemia) Leukemia 3.9e-06 46 62.1 74 62 141
B. petrussis A2 stimulated immune cells (Stimulated PBMC) Stimulated PBMC 9.0e-06 5 31.2 16 5 144
Breast cancer cell line (Breast cancer) Breast cancer 3.5e-05 10 38.4 26 17 152
Lymphoma or lymphoma cell line (B lymphoma) B lymphoma 6.8e-05 58 86.5 67 167 245
Hepatocellular carcinoma (Liver cancer) Liver cancer 7.1e-05 33 76.7 43 104 207
Female hormonal cancer cell line (Breast cancer) Breast cancer 8.3e-05 9 34.6 26 15 152
Invasive liver tumor (Liver cancer) Liver cancer 0.0001 17 39.5 43 38 207
Bone marrow (Leukemia) Leukemia 0.0002 20 27.0 74 23 141


Jump to: Home | General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Enriched GO annotations
For each GO annotation, we tested whether it was enriched in the set of genes of the module. Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of the module's genes in which they appear. We also show the fraction of the module's genes with the given GO annotation that are included in this module ('Hits (%)' column). For completeness, we also list the total number of genes in the module ('Module genes' column), total number of genes in the compendium in which the corresponding annotation is present ('Genes in annotation' column), and the total number of genes in the compendium ('Genes' column).
GO annotation P-value Hits Hits(%) Module genes Genes in annotation Genes
G-protein coupled receptor protein signaling pathway 3.7e-174 124 100 124 245 4566
conjugation without cellular fusion 3.0e-94 79 63.7 124 152 4566
G-protein coupled receptor activity 2.1e-67 67 54.0 124 170 4566
signal transducer activity 1.2e-63 114 91.9 124 1026 4566
rhodopsin-like receptor activity 4.5e-54 56 45.1 124 147 4566
transmembrane receptor activity 3.0e-48 77 62.0 124 448 4566
receptor activity 1.5e-40 78 62.9 124 582 4566
cell surface receptor linked signal transduction 8.1e-40 57 45.9 124 259 4566
sensory perception 1.1e-38 82 66.1 124 700 4566
chemosensory perception 2.3e-36 79 63.7 124 682 4566
signal transduction 8.0e-34 83 66.9 124 831 4566
cell communication 2.2e-29 86 69.3 124 1030 4566
peptide receptor activity 5.6e-29 27 21.7 124 55 4566
peptide receptor activity\, G-protein coupled 3.6e-28 27 21.7 124 58 4566
response to abiotic stimulus 5.2e-26 89 71.7 124 1228 4566
G-protein signaling\, coupled to IP3 second messenger (phospholipase C activating) 2.0e-24 23 18.5 124 48 4566
integral to plasma membrane 1.1e-21 60 48.3 124 612 4566
neuropeptide signaling pathway 1.3e-20 18 14.5 124 33 4566
taxis 3.1e-20 24 19.3 124 76 4566
chemotaxis 2.2e-19 23 18.5 124 73 4566
energy taxis 3.1e-19 23 18.5 124 74 4566
G-protein signaling\, coupled to cAMP nucleotide second messenger 7.1e-19 18 14.5 124 39 4566
glutamate receptor activity 3.7e-18 18 14.5 124 42 4566
G-protein signaling\, coupled to cyclic nucleotide second messenger 5.2e-18 20 16.1 124 57 4566
cytosolic calcium ion concentration elevation 8.8e-17 14 11.2 124 24 4566
cAMP-mediated signaling 2.8e-16 15 12.0 124 31 4566
inflammatory response 3.2e-15 23 18.5 124 108 4566
G-protein signaling\, adenylate cyclase inhibiting pathway 1.4e-14 11 8.8 124 16 4566
thermoregulation 2.0e-14 22 17.7 124 105 4566
G-protein chemoattractant receptor activity 1.0e-11 9 7.2 124 14 4566
nucleotide receptor activity 2.6e-11 9 7.2 124 15 4566
response to starvation 6.1e-10 8 6.4 124 14 4566
intracellular signaling cascade 7.2e-10 30 24.1 124 319 4566
negative regulation of adenylate cyclase activity 1.0e-09 7 5.6 124 10 4566
synaptic transmission 1.1e-09 18 14.5 124 116 4566
feeding behavior 1.2e-09 8 6.4 124 15 4566
chemokine binding 2.7e-09 7 5.6 124 11 4566
regulation of G-protein coupled receptor protein signaling pathway 2.7e-09 7 5.6 124 11 4566
protein kinase C activation 9.5e-09 6 4.8 124 8 4566
vesicle-mediated transport 4.0e-08 21 16.9 124 196 4566
response to biotic stimulus 6.1e-08 39 31.4 124 600 4566
phosphatidylinositol-4\,5-bisphosphate hydrolysis 6.8e-08 6 4.8 124 10 4566
phospholipase C activation 6.8e-08 6 4.8 124 10 4566
heterotrimeric G-protein GTPase\, alpha-subunit 1.4e-07 6 4.8 124 11 4566
chemokine receptor binding 2.3e-07 9 7.2 124 35 4566
MAPKKK cascade (osmolarity sensing) 7.7e-07 7 5.6 124 21 4566
receptor binding 9.2e-07 21 16.9 124 235 4566
invasive growth 1.4e-06 6 4.8 124 15 4566
response to extracellular stimulus 1.9e-06 32 25.8 124 500 4566
MAPKKK cascade 2.9e-06 7 5.6 124 25 4566
coreceptor activity 3.0e-06 5 4.0 124 10 4566
two-component signal transduction system (phosphorelay) 3.9e-06 7 5.6 124 26 4566
cellular morphogenesis 7.2e-06 6 4.8 124 19 4566
neuropeptide receptor activity 7.4e-06 4 3.2 124 6 4566
prostaglandin receptor activity 7.4e-06 4 3.2 124 6 4566
activation of MAPK 9.2e-06 5 4.0 124 12 4566
metabotropic glutamate\, GABA-B-like receptor activity 9.2e-06 5 4.0 124 12 4566
response to stress 1.2e-05 41 33.0 124 792 4566
neuropeptide hormone activity 1.4e-05 5 4.0 124 13 4566
cell motility 4.5e-05 12 9.6 124 113 4566
cellular defense response 4.8e-05 8 6.4 124 50 4566
secretion 6.7e-05 18 14.5 124 240 4566
gamma-aminobutyric acid signaling pathway 9.5e-05 4 3.2 124 10 4566
perception of mechanical stimulus 9.5e-05 4 3.2 124 10 4566


Jump to: Home | General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Visual display
Below is a visual display of the module. Shown are those arrays in which the module's genes significantly change, and the direction of change (induction/repression) in each array is indicated (middle, labeled 'Module changes'; red/green row). The arrays that correspond to the significant clinical attributes are also shown (top; brown rows). The gene sets that compose the module are also shown (left) along with an indication of the membership of the module genes in these gene sets.
You can also view the images within GeneXPress by loading the module gxp file file.
Note: Since there are 593 experiments, this image does not display the individual experiment names, but rather condenses each experiment to a single pixel without displaying its name. You can fully view the image for this module within GeneXPress, by loading any of the four files mentioned in the line above
 
 





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