Module 362 -- Angiogenesis

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General Properties
Below we list the number of gene sets from which the module was composed was originally composed, and the number of genes and experiments that it contains. Clicking on the number of genes will display a detailed list of all the genes in the module. Clicking on the number of experiments will display a detailed list of all the experiments in the module.
Num gene sets: 4
Num genes: 21 (see 1240 additional genes for this module)
Num experiments: 68 (29 induced, 39 repressed)
Parent module: 444
Children modules: 178


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Gene sets
Below we list the gene sets from which the module was originally composed. Clicking on a gene set will display all the genes associated with that gene set. Also listed are all the other modules in which the gene set participates.
pattern specification
angiogenesis
embryonic pattern specification
embryonic development


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Enriched clinical annotations
For each of the clinical annotations, we tested whether it was enriched in the set of arrays in which the module is significantly induced (or repressed). Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of induced (or repressed) module's arrays in which they appear. We also show the fraction of the module's induced (or repressed) arrays with the given annotation ('Hits (%)' column). For completeness, we also list the total number of relevant induced arrays in the module ('Module hits in category' column), total number of arrays in the compendium in which the corresponding annotation is present ('Arrays in annotation' column), and the total number of relevant arrays in the compendium ('Arrays' column). Note that the 'relevant' arrays may be different for each annotation, since it includes only arrays in which the annotation was relevant (i.e., present or not present) and excludes arrays where the value of the annotation was not known. Rows that correspond to annotations that were enriched in the induced arrays of the module have a red background, while rows corresponding to annotations enriched in the repressed arrays have a green background. For each annotation, we also list the other modules in which it was enriched.
Clinical annotation Category P-value Hits Hits(%) Module hits in category Arrays in annotation Arrays
Cell line (NCI60*) NCI60* 3.1e-16 19 65.5 29 135 1945
Cancer and cell line (NCI60*) NCI60* 4.7e-16 19 65.5 29 138 1945
Cell line (NCI60*) NCI60* 8.2e-12 18 46.1 39 135 1945
Cancer and cell line (NCI60*) NCI60* 1.2e-11 18 46.1 39 138 1945
Acute leukemia (Leukemia*) Leukemia* 2.2e-09 16 41.0 39 141 1945
Cancer and cell line (Leukemia*) Leukemia* 2.2e-09 16 41.0 39 141 1945
Cancer (Leukemia*) Leukemia* 2.2e-09 16 41.0 39 141 1945
Hematologic cancer and cell line (Leukemia*) Leukemia* 2.2e-09 16 41.0 39 141 1945
Hematologic cancer (Leukemia*) Leukemia* 2.2e-09 16 41.0 39 141 1945
Hematologic samples and cell lines (Leukemia*) Leukemia* 2.2e-09 16 41.0 39 141 1945
Leukemia (Leukemia*) Leukemia* 2.2e-09 16 41.0 39 141 1945
Leukemia or leukemia cell line (Leukemia*) Leukemia* 2.2e-09 16 41.0 39 141 1945
Monocytes (Leukemia*) Leukemia* 2.2e-09 16 41.0 39 141 1945
Renal cancer cell line (NCI60) NCI60 3.0e-05 9 47.3 19 17 139
Renal cancer or cell line (NCI60) NCI60 3.0e-05 9 47.3 19 17 139
Renal tissue (NCI60) NCI60 3.0e-05 9 47.3 19 17 139


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Enriched GO annotations
For each GO annotation, we tested whether it was enriched in the set of genes of the module. Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of the module's genes in which they appear. We also show the fraction of the module's genes with the given GO annotation that are included in this module ('Hits (%)' column). For completeness, we also list the total number of genes in the module ('Module genes' column), total number of genes in the compendium in which the corresponding annotation is present ('Genes in annotation' column), and the total number of genes in the compendium ('Genes' column).
GO annotation P-value Hits Hits(%) Module genes Genes in annotation Genes
pattern specification 2.6e-49 21 100 21 33 4566
embryonic development 5.5e-41 18 85.7 21 27 4566
embryonic pattern specification 4.6e-39 17 80.9 21 24 4566
angiogenesis 2.4e-37 16 76.1 21 21 4566
development 4.1e-20 21 100 21 554 4566
receptor binding 1.1e-09 11 52.3 21 235 4566
growth factor activity 1.2e-07 7 33.3 21 95 4566
signal transducer activity 2.3e-06 15 71.4 21 1026 4566
regulation of T-cell proliferation 1.1e-05 5 23.8 21 69 4566
lymphocyte proliferation 1.2e-05 5 23.8 21 70 4566
cell communication 1.8e-05 14 66.6 21 1030 4566
T-cell activation 2.4e-05 7 33.3 21 207 4566
lymphocyte activation 2.5e-05 7 33.3 21 209 4566
signal transduction 7.1e-05 12 57.1 21 831 4566
viral host cell process manipulation 7.7e-05 5 23.8 21 102 4566
immune response 0.0001 9 42.8 21 469 4566


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Visual display
Below is a visual display of the module. Shown are those arrays in which the module's genes significantly change, and the direction of change (induction/repression) in each array is indicated (middle, labeled 'Module changes'; red/green row). The arrays that correspond to the significant clinical attributes are also shown (top; brown rows). The gene sets that compose the module are also shown (left) along with an indication of the membership of the module genes in these gene sets.
You can also view the images within GeneXPress by loading the module gxp file file.
 
 





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