Module 374

Jump to: General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
General Properties
Below we list the number of gene sets from which the module was composed was originally composed, and the number of genes and experiments that it contains. Clicking on the number of genes will display a detailed list of all the genes in the module. Clicking on the number of experiments will display a detailed list of all the experiments in the module.
Num gene sets: 3
Num genes: 20 (see 77 additional genes for this module)
Num experiments: 169 (11 induced, 158 repressed)


Jump to: General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Gene sets
Below we list the gene sets from which the module was originally composed. Clicking on a gene set will display all the genes associated with that gene set. Also listed are all the other modules in which the gene set participates.
Pollack99 31 374
Gap Junction Proteins_Connexins
neuropeptide signaling pathway 290 374


Jump to: General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Enriched clinical annotations
For each of the clinical annotations, we tested whether it was enriched in the set of experiments in which the module is significantly induced (or repressed). Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of induced (or repressed) experiments in which they appear. We also show the fraction of experiments with the given annotation that are included in this module ('Hits (%)' column). Rows that correspond to annotations that were enriched in the induced experiments of the module have a red background, while rows corresponding to annotations enriched in the repressed experiments have a green background. For each annotation, we also list the other modules in which it was enriched.
Clinical annotation P-value Hits Hits(%) Modules
Lung 6.43e-76 122 77.215 1 2 5 6 7 8 10 11 12 17 19 21 23 24 33 34 36 38 40 41 44 45 46 52 55 56 58 60 66 68 72 75 76 84 88 89 90 92 93 94 100 104 105 107 108 109 112 113 118 119 121 122 127 129 130 131 137 139 142 148 153 154 164 165 167 168 172 176 180 181 189 190 191 194 203 204 209 210 213 220 222 223 230 234 235 242 262 263 275 290 297 298 310 311 322 324 326 327 342 357 373 374 376 379 382 384 385 390 391 392 401 404 416 421 426 428 431 435 438 450 461 462 464 465 467 468 469 471 473 479 486 487 513 514 520 533 538 540 542 543 549 551 552 556 564 573
NSCLC tumor 5.07e-65 98 62.025 1 2 5 6 7 10 11 12 19 23 24 33 34 36 38 41 44 45 46 52 55 58 60 66 68 72 75 76 84 88 89 90 92 93 94 100 104 107 108 109 112 113 118 121 122 129 130 131 137 139 142 148 153 154 164 165 167 168 172 176 180 181 190 191 194 203 204 209 210 213 220 222 223 230 234 235 242 262 263 275 290 297 298 310 322 324 326 327 342 357 372 373 374 379 382 384 385 392 401 404 426 428 431 435 438 461 462 464 465 467 468 469 471 486 487 514 520 533 542 543 551 552 564 573
NSCLC tumor and cell line 1.62e-60 98 62.025 1 2 5 6 7 10 11 12 19 23 24 33 36 38 41 44 45 46 52 55 58 60 66 68 72 75 76 84 88 89 92 93 94 100 104 107 108 109 112 113 121 122 129 130 131 137 139 142 148 153 154 164 165 167 168 172 176 180 181 194 203 204 209 213 220 222 223 230 234 235 242 262 263 275 290 297 298 310 322 324 326 327 342 357 373 374 379 382 384 385 390 392 401 404 426 428 431 435 438 461 462 464 465 467 468 469 471 486 487 514 520 533 542 543 549 551 552 564 573
Stage T1 all - lung 2.56e-60 84 53.164 1 2 5 6 7 8 10 11 12 17 19 23 24 33 36 38 40 41 44 45 46 52 54 55 58 60 66 68 72 75 76 84 88 89 90 92 93 94 100 104 107 108 109 112 113 118 121 122 129 130 131 137 139 142 148 153 154 164 165 167 168 172 176 180 181 190 194 203 204 209 213 220 222 223 230 234 235 242 262 263 266 290 297 298 310 311 322 324 326 327 342 357 372 373 374 379 381 382 384 385 390 391 392 401 404 416 421 426 431 435 438 461 462 464 465 467 468 471 473 487 513 514 520 533 538 540 542 543 549 551 552 564 573
Lung cancer 1.94e-58 100 63.291 1 2 5 6 7 8 10 11 12 19 23 24 33 34 36 38 40 41 44 45 46 52 55 58 60 64 66 68 72 75 76 84 88 89 92 93 94 100 104 107 108 109 112 113 118 121 122 129 130 131 137 139 142 148 153 154 164 165 167 168 172 176 180 181 190 191 194 203 204 209 210 213 220 222 223 230 234 235 242 262 263 275 280 290 297 298 310 311 322 324 326 327 342 357 373 374 379 382 384 385 390 391 392 401 404 416 426 428 431 435 438 461 462 464 465 467 468 469 471 473 479 486 487 513 514 520 533 540 542 543 549 551 552 564 573
Stage T1 all 1.63e-57 84 53.164 1 2 5 6 7 8 10 11 12 17 19 23 24 33 36 38 40 41 44 45 46 52 55 58 60 66 68 72 75 76 84 88 89 90 92 93 94 100 104 107 108 109 112 113 118 121 122 129 130 131 137 139 142 148 153 154 164 165 167 168 172 176 180 181 190 194 203 204 209 213 220 222 223 230 234 235 242 263 266 290 297 298 310 311 322 324 326 327 342 357 372 373 374 379 381 382 384 385 390 391 392 401 404 416 421 426 431 435 438 461 462 464 465 467 468 471 473 487 513 514 520 533 540 542 543 549 551 552 564 573
Adenocarcinoma (lung) 5.11e-56 85 53.797 1 2 6 7 8 11 12 19 23 24 33 36 38 41 52 54 55 60 66 68 72 76 84 88 89 90 92 93 94 100 104 107 108 109 112 113 118 121 122 129 130 137 139 142 148 153 154 164 165 167 168 172 176 180 181 194 203 204 209 213 220 222 230 234 235 242 263 275 290 297 298 310 322 324 326 342 357 372 373 374 379 382 384 385 401 404 421 426 431 435 438 461 462 464 465 468 471 486 487 514 520 533 540 542 543 549 551 552 564 573
Stage T1 5.34e-55 74 46.835 1 2 5 6 7 8 10 11 12 17 19 23 24 33 34 36 38 40 41 44 45 46 52 54 55 58 60 66 68 72 75 76 84 88 89 90 92 93 94 100 104 107 108 109 112 113 118 119 121 122 129 130 131 137 139 142 143 148 153 154 164 165 167 168 171 172 176 180 181 191 194 203 204 209 213 220 222 223 230 234 235 242 262 263 290 297 298 309 310 311 322 324 326 327 342 357 372 373 374 379 381 382 384 385 390 391 401 404 416 421 426 431 435 438 461 462 464 465 467 468 473 487 513 514 520 533 538 540 542 543 549 551 552 564 573
Stage T1 - lung 5.34e-55 74 46.835 1 2 5 6 7 8 10 11 12 17 19 23 24 33 34 36 38 40 41 44 45 46 52 54 55 58 60 66 68 72 75 76 84 88 89 90 92 93 94 100 104 107 108 109 112 113 118 119 121 122 129 130 131 137 139 142 143 148 153 154 164 165 167 168 171 172 176 180 181 191 194 203 204 209 213 220 222 223 230 234 235 242 262 263 290 297 298 309 310 311 322 324 326 327 342 357 372 373 374 379 381 382 384 385 390 391 401 404 416 421 426 431 435 438 461 462 464 465 467 468 473 487 513 514 520 533 538 540 542 543 549 551 552 564 573
Lung cancer and cell line 8.80e-55 100 63.291 1 2 5 6 7 10 11 12 19 23 24 33 34 36 38 40 41 44 45 46 52 55 58 60 64 66 68 72 75 76 84 88 89 92 93 94 100 104 107 108 109 112 113 118 119 121 122 129 130 131 137 139 142 148 153 154 164 165 167 168 171 172 176 180 181 190 191 194 203 204 209 210 213 220 222 223 230 234 235 242 262 263 275 290 297 298 310 322 324 326 327 342 357 373 374 379 382 384 385 390 391 392 401 404 416 426 428 431 435 438 461 462 464 465 467 468 469 471 473 479 486 487 513 514 520 533 540 542 543 549 551 552 564 573
Adenocarcinoma (various tissues) 7.35e-21 90 56.962 2 6 7 9 10 11 12 19 20 23 24 26 36 38 40 41 43 48 55 58 60 66 67 68 78 83 88 89 90 92 93 94 95 96 100 101 104 106 107 108 112 113 117 122 129 130 131 135 137 139 140 142 143 148 153 154 157 162 163 164 165 166 167 172 176 180 181 189 190 192 203 204 205 206 207 209 211 220 221 222 223 230 234 235 239 242 249 257 258 263 279 280 285 286 290 293 295 297 298 306 310 322 324 326 334 342 343 357 364 373 374 379 382 384 385 389 397 401 404 417 421 422 426 427 431 435 438 440 443 447 461 464 469 479 480 486 487 495 506 513 514 515 520 521 523 542 551 552 564 567 573
Cancer tissue 2.31e-10 126 79.746 1 2 3 5 6 7 8 10 11 12 13 19 23 24 27 29 33 36 38 40 41 44 45 46 47 52 55 58 60 63 64 65 66 68 70 72 75 76 78 84 88 89 90 92 93 94 99 100 104 105 107 109 111 112 113 117 118 120 122 127 129 130 131 137 138 140 142 148 153 154 157 164 165 167 168 172 173 174 175 176 181 189 190 194 201 203 204 206 207 209 211 213 214 216 220 222 230 234 235 241 242 247 248 249 250 267 274 290 291 295 297 298 316 324 326 327 329 330 340 341 342 347 357 372 373 374 379 381 382 384 385 387 391 401 404 407 411 416 421 422 426 428 431 435 438 440 446 461 462 464 466 468 469 474 479 483 486 487 497 500 506 512 513 514 515 520 525 533 540 543 549 552 564 570 573
Normal lung 1.60e-08 13 8.227 1 3 5 7 8 10 16 17 18 21 31 36 40 41 52 53 54 56 68 72 89 90 94 96 98 102 104 105 112 125 126 127 128 129 130 139 148 153 154 158 165 167 168 170 176 180 181 189 198 203 204 210 211 219 222 230 235 242 244 252 259 297 298 302 320 322 326 327 342 344 357 374 376 379 382 384 390 397 401 403 404 410 421 422 426 428 438 450 451 461 462 469 470 471 528 533 538 543 552 556 557 571 573
Cancer tissue and cell line 5.70e-08 142 89.873 1 2 5 6 10 11 12 19 23 24 27 33 36 38 41 44 45 46 47 54 55 58 60 63 64 66 75 76 78 84 85 88 89 90 92 94 99 100 105 107 109 112 113 117 120 121 122 125 127 129 130 131 135 137 138 139 140 142 148 153 154 158 164 165 168 171 172 173 174 175 176 178 180 184 189 190 194 199 201 203 204 205 206 208 209 213 214 216 220 222 230 234 235 241 247 249 250 259 274 287 290 291 292 294 295 297 309 316 321 324 326 327 329 330 342 343 345 357 372 373 374 382 385 387 390 391 397 401 404 407 410 416 418 421 422 426 431 435 440 461 462 464 466 467 468 473 474 479 497 505 506 512 513 514 536 540 543 549 552 572 573
SQCLC 1.50e-07 14 8.860 2 5 6 7 10 11 12 19 23 24 33 36 38 41 45 46 51 55 58 60 64 66 68 75 76 88 92 94 100 101 104 107 108 109 112 121 122 129 130 132 137 139 142 148 153 154 165 172 176 180 181 209 213 223 230 234 242 290 297 298 310 324 326 327 342 357 373 374 379 382 401 404 410 426 428 431 435 461 462 467 486 487 556 564 569 577
AD - extrapulmonary metastasis 1.66e-07 9 5.696 1 19 24 58 60 68 72 92 93 94 100 107 129 130 131 139 153 154 164 165 167 172 194 209 213 234 297 298 324 342 357 373 374 381 382 385 401 404 416 426 431 438 461 464 514 533 543
Stage T1a 1.10e-05 7 4.430 68 92 94 153 165 167 234 290 298 324 373 374 382 385 426 438
Stage T1a - lung 1.10e-05 7 4.430 68 92 94 153 165 167 234 290 298 324 373 374 382 385 426 438
Stage T2 all - lung 5.15e-05 11 6.962 52 68 92 139 153 154 165 167 180 204 234 297 298 324 357 373 374 382 385 401 404 438 461 573
Stage T2 0.00012 7 4.430 2 6 11 12 19 23 24 52 55 60 66 68 72 92 94 100 122 129 137 153 154 164 165 167 204 213 234 297 298 324 342 357 373 374 382 384 385 401 404 426 438 461 533 573
Stage T2 - lung 0.00012 7 4.430 2 6 11 12 19 23 24 52 55 60 66 68 72 92 94 100 122 129 137 153 154 164 165 167 204 213 234 297 298 324 342 357 373 374 382 384 385 401 404 426 438 461 533 573


Jump to: General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Enriched GO annotations
For each GO annotation, we tested whether it was enriched in the set of genes of the module. Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of genes in which they appear. We also show the fraction of genes with the given GO annotation that are included in this module ('Hits (%)' column).
GO annotation P-value Hits Hits(%)
neuropeptide signaling pathway 4.44e-33 16 80
G-protein coupled receptor protein signaling pathway 3.74e-20 16 80
cell surface receptor linked signal transduction 4.36e-19 16 80
cell communication 9.69e-13 16 80
signal transduction 1.45e-11 16 80
feeding behavior 3.98e-08 4 20
secretion 1.42e-07 8 40
gap junction 1.14e-06 3 15
neuropeptide hormone activity 2.99e-06 3 15
hormone activity 9.32e-06 4 20
cell-cell signaling 1.11e-05 6 30
synaptic transmission 1.63e-05 5 25
signal transducer activity 1.82e-05 12 60
receptor binding 6.60e-05 6 30


Jump to: General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Visual display
Below is a visual display of the module. Shown are those arrays in which the module's genes significantly change, and the direction of change (induction/repression) in each array is indicated (middle, labeled 'Module changes'; red/green row). The arrays that correspond to the significant clinical attributes are also shown (top; brown rows). The gene sets that compose the module are also shown (left) along with an indication of the membership of the module genes in these gene sets.
You can also view the images within GeneXPress by loading the module gxp file file.
 
 





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