Module 385 -- Heparin binding

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General Properties
Below we list the number of gene sets from which the module was composed was originally composed, and the number of genes and experiments that it contains. Clicking on the number of genes will display a detailed list of all the genes in the module. Clicking on the number of experiments will display a detailed list of all the experiments in the module.
Num gene sets: 2
Num genes: 28 (see 1628 additional genes for this module)
Num experiments: 336 (63 induced, 273 repressed)
Parent module: None
Children modules: None


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Gene sets
Below we list the gene sets from which the module was originally composed. Clicking on a gene set will display all the genes associated with that gene set. Also listed are all the other modules in which the gene set participates.
heparin binding
glycosaminoglycan binding


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Enriched clinical annotations
For each of the clinical annotations, we tested whether it was enriched in the set of arrays in which the module is significantly induced (or repressed). Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of induced (or repressed) module's arrays in which they appear. We also show the fraction of the module's induced (or repressed) arrays with the given annotation ('Hits (%)' column). For completeness, we also list the total number of relevant induced arrays in the module ('Module hits in category' column), total number of arrays in the compendium in which the corresponding annotation is present ('Arrays in annotation' column), and the total number of relevant arrays in the compendium ('Arrays' column). Note that the 'relevant' arrays may be different for each annotation, since it includes only arrays in which the annotation was relevant (i.e., present or not present) and excludes arrays where the value of the annotation was not known. Rows that correspond to annotations that were enriched in the induced arrays of the module have a red background, while rows corresponding to annotations enriched in the repressed arrays have a green background. For each annotation, we also list the other modules in which it was enriched.
Clinical annotation Category P-value Hits Hits(%) Module hits in category Arrays in annotation Arrays
Lung tissue, cancer or cell line (Lung cancer*) Lung cancer* 7.8e-67 146 53.6 272 276 1945
Cancer and cell line (Lung cancer*) Lung cancer* 1.2e-62 136 50 272 252 1945
Cancer (Lung cancer*) Lung cancer* 1.2e-62 136 50 272 252 1945
Lung cancer (Lung cancer*) Lung cancer* 5.5e-59 129 47.4 272 238 1945
Lung cancer or cell line (Lung cancer*) Lung cancer* 5.5e-59 129 47.4 272 238 1945
Non small cell lung cancer and cell line (Lung cancer*) Lung cancer* 3.3e-48 110 40.4 272 205 1945
Non small cell lung cancer (Lung cancer*) Lung cancer* 3.3e-48 110 40.4 272 205 1945
Liver tissue (Liver cancer*) Liver cancer* 5.3e-10 24 38.0 63 187 1945
Hematologic samples and cell lines (Various tumors) Various tumors 1.4e-09 21 70 30 37 154
Hematologic samples (Various tumors) Various tumors 1.4e-09 21 70 30 37 154
Liver tissue, cancer or cell line (Liver cancer*) Liver cancer* 1.6e-09 24 38.0 63 197 1945
Hematologic cancer and cell line (Various tumors) Various tumors 4.1e-08 18 60 30 31 154
Hematologic cancer (Various tumors) Various tumors 4.1e-08 18 60 30 31 154
Primary blood mononuclear cells (Various tumors) Various tumors 4.1e-08 18 60 30 31 154
Hepatitis infected liver (Liver cancer*) Liver cancer* 7.9e-07 18 28.5 63 156 1945
Lymphocytes (Various tumors) Various tumors 5.5e-06 15 50 30 28 154
Monocytes (Various tumors) Various tumors 5.5e-06 15 50 30 28 154
Liver cancer cell line (Liver cancer) Liver cancer 8.8e-06 6 40 15 10 207
Cell line (Liver cancer) Liver cancer 1.8e-05 6 40 15 11 207
Breast tissue or cancer (Breast cancer*) Breast cancer* 6.1e-05 13 20.6 63 118 1945
Female hormonal tissue or cancer (Breast cancer*) Breast cancer* 6.1e-05 13 20.6 63 118 1945
Colon cancer (Liver cancer) Liver cancer 8.7e-05 4 26.6 15 5 207
Colon cancer metastasis to liver (Liver cancer) Liver cancer 8.7e-05 4 26.6 15 5 207
Colon cancer or cell line (Liver cancer) Liver cancer 8.7e-05 4 26.6 15 5 207
Colon tissue, cancer or cell line (Liver cancer) Liver cancer 8.7e-05 4 26.6 15 5 207
Female hormonal tissue, cancer or cell line (Breast cancer*) Breast cancer* 9.8e-05 14 22.2 63 141 1945
Breast tissue, cancer or cell line (Breast cancer*) Breast cancer* 0.0001 14 22.2 63 142 1945
Metastasis (Liver cancer) Liver cancer 0.0002 5 33.3 15 10 207
T cells (Various tumors) Various tumors 0.0002 5 16.6 30 5 154
Stage T1 (Lung cancer) Lung cancer 0.0003 108 86.4 125 153 195
Cancer and cell line (Liver cancer) Liver cancer 0.0004 15 100 15 126 207


Jump to: Home | General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Enriched GO annotations
For each GO annotation, we tested whether it was enriched in the set of genes of the module. Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of the module's genes in which they appear. We also show the fraction of the module's genes with the given GO annotation that are included in this module ('Hits (%)' column). For completeness, we also list the total number of genes in the module ('Module genes' column), total number of genes in the compendium in which the corresponding annotation is present ('Genes in annotation' column), and the total number of genes in the compendium ('Genes' column).
GO annotation P-value Hits Hits(%) Module genes Genes in annotation Genes
glycosaminoglycan binding 4.7e-62 28 100 28 44 4566
heparin binding 2.6e-56 26 92.8 28 40 4566
binding 4.0e-18 28 100 28 1103 4566
cell communication 4.6e-08 20 71.4 28 1030 4566
extracellular space 2.3e-07 10 35.7 28 212 4566
receptor binding 6.2e-07 10 35.7 28 235 4566
inflammatory response 3.7e-05 6 21.4 28 108 4566
immune response 5.0e-05 11 39.2 28 469 4566
cell adhesion molecule activity 5.1e-05 6 21.4 28 114 4566
chemokine receptor binding 5.2e-05 4 14.2 28 35 4566
chemotaxis 6.7e-05 5 17.8 28 73 4566
energy taxis 7.1e-05 5 17.8 28 74 4566
lipid transporter activity 8.0e-05 4 14.2 28 39 4566
taxis 8.1e-05 5 17.8 28 76 4566
response to extracellular stimulus 9.1e-05 11 39.2 28 500 4566
response to biotic stimulus 9.7e-05 12 42.8 28 600 4566
cell-cell signaling 0.0001 7 25 28 194 4566


Jump to: Home | General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Visual display
Below is a visual display of the module. Shown are those arrays in which the module's genes significantly change, and the direction of change (induction/repression) in each array is indicated (middle, labeled 'Module changes'; red/green row). The arrays that correspond to the significant clinical attributes are also shown (top; brown rows). The gene sets that compose the module are also shown (left) along with an indication of the membership of the module genes in these gene sets.
You can also view the images within GeneXPress by loading the module gxp file file.
 
 





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