Module 409 -- G-protein/cAMP signaling

General Properties
Below we list the number of gene sets from which the module was composed was originally composed, and the number of genes and experiments that it contains. Clicking on the number of genes will display a detailed list of all the genes in the module. Clicking on the number of experiments will display a detailed list of all the experiments in the module.
Num gene sets:	5
Num genes:	23 (see 1273 additional genes for this module)
Num experiments:	230 (93 induced, 137 repressed)
Parent module:	None
Children modules:	364

Gene sets
Below we list the gene sets from which the module was originally composed. Clicking on a gene set will display all the genes associated with that gene set. Also listed are all the other modules in which the gene set participates.
G_protein signaling, coupled to cyclic nucleotide second messenger
cAMP_mediated signaling
G_protein signaling, coupled to cAMP nucleotide second messenger
G_protein signaling, adenylate cyclase inhibiting pathway
toxin activity

Enriched clinical annotations
For each of the clinical annotations, we tested whether it was enriched in the set of arrays in which the module is significantly induced (or repressed). Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of induced (or repressed) module's arrays in which they appear. We also show the fraction of the module's induced (or repressed) arrays with the given annotation ('Hits (%)' column). For completeness, we also list the total number of relevant induced arrays in the module ('Module hits in category' column), total number of arrays in the compendium in which the corresponding annotation is present ('Arrays in annotation' column), and the total number of relevant arrays in the compendium ('Arrays' column). Note that the 'relevant' arrays may be different for each annotation, since it includes only arrays in which the annotation was relevant (i.e., present or not present) and excludes arrays where the value of the annotation was not known. Rows that correspond to annotations that were enriched in the induced arrays of the module have a red background, while rows corresponding to annotations enriched in the repressed arrays have a green background. For each annotation, we also list the other modules in which it was enriched.
Clinical annotation	Category	P-value	Hits	Hits(%)	Module hits in category	Arrays in annotation	Arrays
Liver tissue (General compendium)	General compendium	2.0e-40	59	63.4	93	187	1946
Liver tissue, cancer or cell line (General compendium)	General compendium	6.7e-39	59	63.4	93	197	1946
Hepatitis infected liver (General compendium)	General compendium	4.4e-26	44	47.3	93	156	1946
Non-tumor liver tissue (Liver cancer)	Liver cancer	3.3e-24	53	89.8	59	76	207
Liver tissue, cancer or cell line (General compendium)	General compendium	1.0e-21	54	39.4	137	197	1946
Hepatitis infected liver (General compendium)	General compendium	1.1e-19	46	33.5	137	156	1946
Liver tissue (General compendium)	General compendium	9.8e-18	48	35.0	137	187	1946
Adenocarcinoma (General compendium)	General compendium	1.2e-14	73	53.2	137	466	1946
Cancer and cell line (Liver cancer)	Liver cancer	1.9e-13	54	98.1	55	126	207
Hepatocellular carcinoma (Liver cancer)	Liver cancer	3.7e-10	47	85.4	55	104	207
Cancer (Liver cancer)	Liver cancer	9.1e-09	48	87.2	55	115	207
Non small cell lung cancer (General compendium)	General compendium	1.2e-08	37	27.0	137	205	1946
Adenocarcinoma (Liver cancer)	Liver cancer	4.0e-08	43	78.1	55	97	207
Invasive liver tumor (Liver cancer)	Liver cancer	1.1e-07	24	43.6	55	38	207
Non small cell lung cancer and cell line (General compendium)	General compendium	1.3e-07	37	27.0	137	223	1946
Lung cancer (General compendium)	General compendium	1.5e-07	39	28.4	137	244	1946
Cancer and cell line (General compendium)	General compendium	2.6e-07	124	90.5	137	1429	1946
Lung cancer or cell line (General compendium)	General compendium	1.1e-06	39	28.4	137	262	1946
Cancer (General compendium)	General compendium	1.5e-06	104	75.9	137	1110	1946
Cell line (Breast cancer)	Breast cancer	6.3e-06	9	81.8	11	30	152
Lung tissue, cancer or cell line (General compendium)	General compendium	8.3e-06	41	29.9	137	304	1946
Live bacteria stimulated immune cells (Stimulated PBMC)	Stimulated PBMC	5.2e-05	4	40	10	5	148
Normal tissue (Liver cancer)	Liver cancer	8.2e-05	11	18.6	59	14	207
Breast cancer cell line (Breast cancer)	Breast cancer	0.0002	6	54.5	11	17	152

Enriched GO annotations
For each GO annotation, we tested whether it was enriched in the set of genes of the module. Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of the module's genes in which they appear. We also show the fraction of the module's genes with the given GO annotation that are included in this module ('Hits (%)' column). For completeness, we also list the total number of genes in the module ('Module genes' column), total number of genes in the compendium in which the corresponding annotation is present ('Genes in annotation' column), and the total number of genes in the compendium ('Genes' column).
GO annotation	P-value	Hits	Hits(%)	Module genes	Genes in annotation	Genes
G-protein signaling\, coupled to cyclic nucleotide second messenger	3.2e-40	21	91.3	23	57	4609
G-protein signaling\, coupled to cAMP nucleotide second messenger	1.7e-27	15	65.2	23	39	4609
intracellular signaling cascade	6.4e-23	21	91.3	23	322	4609
G-protein coupled receptor activity	1.6e-20	17	73.9	23	170	4609
cAMP-mediated signaling	2.2e-19	11	47.8	23	31	4609
G-protein coupled receptor protein signaling pathway	4.7e-16	16	69.5	23	246	4609
transmembrane receptor activity	9.6e-15	18	78.2	23	449	4609
rhodopsin-like receptor activity	1.8e-14	13	56.5	23	147	4609
signal transduction	4.3e-14	21	91.3	23	841	4609
receptor activity	1.0e-12	18	78.2	23	585	4609
signal transducer activity	3.2e-12	21	91.3	23	1035	4609
cell communication	3.7e-12	21	91.3	23	1043	4609
adenylate cyclase activation	1.2e-11	6	26.0	23	13	4609
G-protein signaling\, adenylate cyclase activating pathway	3.6e-11	6	26.0	23	15	4609
peptide receptor activity	4.9e-09	7	30.4	23	55	4609
peptide receptor activity\, G-protein coupled	7.2e-09	7	30.4	23	58	4609
G-protein signaling\, adenylate cyclase inhibiting pathway	8.1e-09	5	21.7	23	16	4609
conjugation without cellular fusion	2.1e-08	9	39.1	23	153	4609
integral to plasma membrane	1.2e-07	14	60.8	23	616	4609
G-protein signaling\, coupled to IP3 second messenger (phospholipase C activating)	2.8e-06	5	21.7	23	48	4609
adrenoceptor activity	3.7e-06	3	13.0	23	7	4609
cytosolic calcium ion concentration elevation	4.6e-06	4	17.3	23	24	4609
thermoregulation	9.4e-06	6	26.0	23	106	4609
inflammatory response	1.1e-05	6	26.0	23	109	4609
negative regulation of adenylate cyclase activity	1.2e-05	3	13.0	23	10	4609
secretin-like receptor activity	2.3e-05	3	13.0	23	12	4609
glutamate receptor activity	4.6e-05	4	17.3	23	42	4609
response to biotic stimulus	5.2e-05	11	47.8	23	602	4609
secretion	0.0001	7	30.4	23	242	4609

Visual display

Below is a visual display of the module. Shown are those arrays in which the module's genes significantly change, and the direction of change (induction/repression) in each array is indicated (middle, labeled 'Module changes'; red/green row). The arrays that correspond to the significant clinical attributes are also shown (top; brown rows). The gene sets that compose the module are also shown (left) along with an indication of the membership of the module genes in these gene sets.

You can also view the images within GeneXPress by loading the module gxp file file.

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