Module 452

Jump to: General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
General Properties
Below we list the number of gene sets from which the module was composed was originally composed, and the number of genes and experiments that it contains. Clicking on the number of genes will display a detailed list of all the genes in the module. Clicking on the number of experiments will display a detailed list of all the experiments in the module.
Num gene sets: 2
Num genes: 17 (see 35 additional genes for this module)
Num experiments: 89 (33 induced, 56 repressed)


Jump to: General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Gene sets
Below we list the gene sets from which the module was originally composed. Clicking on a gene set will display all the genes associated with that gene set. Also listed are all the other modules in which the gene set participates.
Cysteine_metabolism 452 530
response to oxidative stress 452 530


Jump to: General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Enriched clinical annotations
For each of the clinical annotations, we tested whether it was enriched in the set of experiments in which the module is significantly induced (or repressed). Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of induced (or repressed) experiments in which they appear. We also show the fraction of experiments with the given annotation that are included in this module ('Hits (%)' column). Rows that correspond to annotations that were enriched in the induced experiments of the module have a red background, while rows corresponding to annotations enriched in the repressed experiments have a green background. For each annotation, we also list the other modules in which it was enriched.
Clinical annotation P-value Hits Hits(%) Modules
Liver tissue 7.19e-09 16 48.484 1 2 3 5 6 8 9 10 11 12 15 16 17 18 19 23 24 26 27 33 34 38 40 41 43 44 45 46 47 48 49 52 53 54 55 57 58 60 63 64 66 67 73 75 76 78 79 84 85 88 92 93 94 95 96 98 99 100 101 106 107 108 109 112 117 118 121 122 123 125 128 129 130 131 132 134 135 137 139 140 143 146 154 158 162 163 164 165 170 171 172 176 180 184 185 186 190 191 193 197 198 199 205 207 208 209 212 213 220 221 223 227 234 235 236 239 247 248 249 251 252 253 257 259 262 263 265 286 287 288 289 292 293 294 295 297 305 306 309 310 315 320 321 324 327 335 337 342 343 345 349 353 354 357 364 367 370 372 373 375 385 386 397 401 404 405 406 410 415 417 422 423 424 426 432 434 436 437 440 445 452 458 461 468 469 474 477 478 479 481 484 485 486 495 496 505 506 507 510 514 515 523 528 529 530 536 544 545 546 553 556 564 566
Liver tissue or cell line 1.56e-08 16 48.484 1 2 3 5 6 8 9 10 11 12 15 16 17 18 19 23 24 27 33 34 38 40 41 43 44 45 46 47 48 49 52 53 54 55 57 58 60 63 64 66 67 72 73 75 76 78 79 84 85 88 92 93 94 95 96 98 99 100 101 106 107 108 109 112 117 118 121 122 123 125 128 129 130 131 132 134 135 137 139 140 146 154 158 162 163 164 165 170 171 172 176 180 184 185 186 190 191 193 197 198 199 205 207 208 209 212 213 220 221 223 227 234 235 236 239 247 248 249 250 251 252 253 257 259 262 263 265 283 286 287 288 289 292 293 294 295 297 305 306 309 310 315 320 321 324 327 335 337 342 343 345 349 353 354 357 364 367 370 372 373 375 385 386 397 401 402 404 405 406 410 415 417 422 423 424 426 432 434 436 437 440 445 452 454 457 458 461 468 469 474 477 478 479 481 484 486 495 496 505 506 507 510 514 515 523 528 529 530 536 544 545 546 553 556 564 566
HBV infected 2.07e-07 13 39.393 1 2 5 6 8 9 10 11 12 15 17 18 19 23 24 27 33 34 38 40 41 43 44 45 46 47 48 49 52 53 54 55 57 58 60 63 64 66 67 73 75 76 78 84 85 88 92 93 94 95 96 98 99 100 101 106 107 108 109 112 117 118 121 123 125 129 130 131 132 134 135 137 140 144 146 154 158 163 164 165 172 176 180 184 185 190 191 193 197 198 199 205 207 209 212 213 221 223 227 234 235 239 247 248 249 251 252 257 259 262 263 265 276 286 287 288 289 292 293 294 295 297 305 306 309 310 319 320 324 327 337 342 343 345 349 353 354 357 364 367 370 372 373 375 385 386 397 401 404 406 410 415 417 422 423 424 426 432 434 436 440 445 452 458 461 468 469 474 477 478 479 481 485 486 495 496 505 506 507 510 514 515 523 529 530 536 544 545 546 553 566
Hepatitis infected 4.59e-07 13 39.393 1 2 5 6 8 9 10 11 12 15 17 19 23 24 27 33 34 38 40 41 43 44 45 46 47 48 49 52 53 54 55 57 58 60 63 64 66 67 73 75 76 78 79 84 85 88 92 93 94 95 96 98 99 100 101 106 107 108 109 112 117 118 121 123 125 128 129 130 131 132 134 135 137 140 144 146 154 158 163 164 165 170 171 172 176 180 184 185 190 191 193 197 198 199 205 207 208 209 212 213 221 223 227 234 235 239 247 248 249 251 252 257 259 262 263 265 276 286 287 288 289 292 293 294 295 297 305 306 309 310 319 320 324 327 337 342 343 345 349 353 354 357 364 367 370 372 373 375 385 386 397 401 404 406 410 415 417 422 423 424 426 434 436 440 445 452 458 461 468 469 474 477 478 479 481 485 486 495 496 505 506 507 510 514 515 523 529 530 536 544 545 546 553 564 566
Metastasis (liver, lung) 6.19e-07 6 10.714 10 40 43 58 78 93 105 106 107 109 117 130 131 132 135 139 140 164 172 184 185 186 194 205 209 212 220 221 227 234 235 239 246 247 249 265 276 286 294 295 305 306 310 327 343 349 354 370 373 397 401 415 422 432 434 440 452 458 464 479 493 495 496 505 506 510 526 529 530 536
HCC 3.19e-05 9 27.272 3 8 9 10 15 16 17 18 19 23 24 27 40 41 43 44 47 48 49 52 53 54 55 57 58 63 64 67 72 76 78 88 90 92 93 95 98 99 101 106 108 117 118 123 125 129 130 132 135 137 140 143 144 154 158 162 163 164 165 171 172 180 184 185 189 190 193 198 205 207 208 209 212 221 223 234 235 239 247 249 251 252 257 259 263 286 289 292 293 294 295 305 306 309 310 337 342 343 345 353 354 367 372 373 375 391 394 397 415 421 422 424 432 436 440 452 458 469 470 474 478 479 481 486 495 505 506 507 510 514 515 523 526 536 543 544 545 553 566 573
Liver non-tumor 0.00019 7 21.212 1 2 5 6 8 9 10 11 12 15 18 19 23 24 26 27 33 34 38 40 41 43 44 45 46 47 48 49 53 54 55 57 58 60 63 64 66 73 75 76 78 79 84 85 88 92 93 94 95 96 98 99 100 101 106 107 108 109 112 117 118 121 122 123 124 125 128 129 130 131 132 134 135 137 140 146 154 158 162 163 164 165 170 171 172 176 180 184 185 190 191 193 197 198 199 205 207 208 209 212 213 220 221 223 225 227 234 235 236 238 239 241 244 247 248 249 252 253 257 259 262 263 265 276 283 286 287 288 289 292 294 295 297 301 302 305 306 309 310 315 319 320 321 324 327 335 337 342 343 345 349 353 354 357 364 370 372 373 375 385 397 401 403 404 405 410 415 417 422 423 424 426 431 434 436 437 440 445 452 456 458 461 468 469 470 474 478 479 481 484 485 486 494 495 496 505 506 521 523 528 529 536 544 545 546 556 566
Colon metastasis to liver 0.00021 3 5.357 10 40 43 58 78 93 101 106 107 109 130 131 132 135 139 140 164 167 172 184 186 205 209 212 221 227 235 247 249 286 294 295 297 305 306 310 343 349 354 357 370 373 401 415 422 438 440 452 458 464 479 493 495 505 506 526 530 556
p53 negative HCC 0.00029 5 15.151 9 19 23 24 27 40 43 48 67 93 95 99 106 117 123 132 135 154 163 164 184 190 193 205 212 235 239 257 263 286 297 305 310 343 373 415 432 440 452 474 479 486 495 505 506 510 514 553
Prostate 0.00032 11 19.642 5 6 7 11 12 13 15 16 18 19 20 22 23 24 25 28 29 32 38 41 42 43 44 45 52 53 55 60 62 66 68 72 74 77 81 83 84 88 89 91 93 96 100 103 104 106 111 112 113 114 115 116 118 137 144 146 149 150 151 152 157 159 176 181 183 202 203 217 220 242 273 298 299 307 323 342 351 355 363 379 387 405 419 429 446 447 452 494 519 521 524 542 552 564 570
invasive liver tumor 0.00033 5 15.151 3 8 9 15 16 17 18 23 27 40 43 48 49 52 53 54 55 57 64 72 78 93 95 98 99 105 106 107 108 109 117 118 124 125 126 129 131 135 140 144 146 158 163 164 172 180 184 190 198 205 209 212 221 223 234 235 239 244 247 249 252 257 263 287 294 295 302 305 306 320 337 342 343 354 364 372 373 375 397 417 422 424 432 440 452 458 469 474 478 479 481 486 495 505 506 515 523 536 544 545 573


Jump to: General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Enriched GO annotations
For each GO annotation, we tested whether it was enriched in the set of genes of the module. Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of genes in which they appear. We also show the fraction of genes with the given GO annotation that are included in this module ('Hits (%)' column).
GO annotation P-value Hits Hits(%)
response to oxidative stress 8.76e-26 11 64.705
glutathione peroxidase activity 7.28e-11 4 23.529
peroxidase activity 1.46e-10 5 29.411
oxidoreductase activity 1.05e-07 8 47.058
electron transporter activity 1.69e-07 8 47.058
response to stress 6.33e-07 11 64.705
catalytic activity 1.13e-06 14 82.352


Jump to: General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Visual display
Below is a visual display of the module. Shown are those arrays in which the module's genes significantly change, and the direction of change (induction/repression) in each array is indicated (middle, labeled 'Module changes'; red/green row). The arrays that correspond to the significant clinical attributes are also shown (top; brown rows). The gene sets that compose the module are also shown (left) along with an indication of the membership of the module genes in these gene sets.
You can also view the images within GeneXPress by loading the module gxp file file.
 
 





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