Module 466

Jump to: General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display

General Properties
Below we list the number of gene sets from which the module was composed was originally composed, and the number of genes and experiments that it contains. Clicking on the number of genes will display a detailed list of all the genes in the module. Clicking on the number of experiments will display a detailed list of all the experiments in the module.
Num gene sets:	2
Num genes:	6 (see 218 additional genes for this module)
Num experiments:	44 (1 induced, 43 repressed)

Jump to: General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display

Gene sets
Below we list the gene sets from which the module was originally composed. Clicking on a gene set will display all the genes associated with that gene set. Also listed are all the other modules in which the gene set participates.
peripheral nervous system development	466 560
3',5'_cyclic_nucleotide phosphodiesterase activity

Jump to: General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display

Enriched clinical annotations
For each of the clinical annotations, we tested whether it was enriched in the set of experiments in which the module is significantly induced (or repressed). Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of induced (or repressed) experiments in which they appear. We also show the fraction of experiments with the given annotation that are included in this module ('Hits (%)' column). Rows that correspond to annotations that were enriched in the induced experiments of the module have a red background, while rows corresponding to annotations enriched in the repressed experiments have a green background. For each annotation, we also list the other modules in which it was enriched.
Clinical annotation	P-value	Hits	Hits(%)	Modules
Blood cancer	8.59e-25	39	90.697	1 5 11 27 33 37 46 47 61 63 64 65 66 69 70 75 79 85 94 97 99 100 102 105 112 117 119 120 124 128 129 136 138 145 169 170 173 174 175 176 178 179 182 188 199 201 204 214 216 219 237 238 241 244 245 247 248 250 254 255 261 267 277 289 291 301 308 312 313 315 316 317 328 329 330 340 341 345 347 358 361 375 378 387 407 411 416 433 451 456 459 466 500 502 512 525 532 537 539 554 562
Blood cancer and cell line	3.56e-20	39	90.697	4 5 15 16 17 21 27 31 33 37 46 47 56 57 61 63 64 65 69 70 75 76 79 82 84 85 86 87 94 97 98 99 102 105 114 117 119 120 124 125 126 128 136 138 145 151 158 161 169 170 171 173 174 175 177 178 179 182 188 198 199 201 204 208 214 216 219 233 237 238 241 243 244 245 247 248 250 252 254 255 259 261 265 267 273 277 278 289 291 292 300 301 303 308 312 313 315 316 317 328 329 330 332 340 341 344 345 347 358 361 375 376 378 387 399 403 407 411 433 436 442 451 456 459 466 485 490 491 500 502 512 518 522 525 532 537 539 554 562 568
Leukemia tissue	9.27e-19	28	65.116	1 2 3 5 8 11 12 24 27 33 44 45 46 47 52 54 57 61 63 64 65 66 75 76 79 84 85 88 92 94 99 100 102 105 112 117 118 119 120 124 126 128 129 137 138 145 156 165 169 170 171 173 174 175 176 178 187 188 197 199 204 208 216 219 237 238 240 241 244 247 248 250 254 259 267 287 289 291 292 300 301 302 308 312 313 315 316 324 328 330 331 340 341 344 345 347 361 375 399 403 407 411 416 424 433 436 437 445 451 456 466 485 500 502 503 534 537 539 554 576
Blood and blood cells and cell lines	4.83e-18	39	90.697	4 15 17 21 27 31 33 37 46 56 57 61 63 64 65 69 70 73 75 76 79 82 85 86 87 94 97 98 99 102 114 117 119 120 124 126 128 136 138 145 151 161 169 170 171 173 174 175 177 178 179 182 188 198 199 201 208 214 216 219 233 238 241 244 247 248 250 252 254 255 259 261 265 267 273 278 280 289 291 292 300 301 303 308 312 315 316 317 328 329 330 332 340 341 345 347 358 361 375 376 378 387 399 403 407 411 433 436 439 449 451 456 459 466 481 488 490 500 512 518 522 525 531 532 537 538 539 541 544 562
Leukemia tissue or cell line	6.42e-18	28	65.116	1 2 3 5 6 8 11 12 24 27 33 38 44 45 46 47 52 55 57 61 63 64 65 66 75 76 79 84 85 88 92 94 99 100 102 105 112 117 118 119 120 122 124 126 128 129 137 138 145 156 165 169 170 173 174 175 176 178 187 188 199 204 208 216 219 220 237 238 240 241 244 247 248 250 254 259 267 287 289 291 292 300 301 302 308 312 313 315 316 324 328 330 331 340 341 344 345 347 361 362 375 399 403 407 411 416 424 433 436 437 445 451 456 466 485 500 502 503 534 537 539 554 576
ALL (ALL and MLL)	3.43e-12	17	39.534	1 2 5 6 11 12 19 23 24 27 33 36 38 44 45 46 47 51 55 60 63 64 65 66 75 76 79 80 84 85 88 92 94 96 99 100 105 107 108 112 113 117 120 122 128 129 137 138 146 165 168 170 173 174 175 176 178 189 199 204 213 214 216 220 222 241 247 248 250 259 267 287 289 291 316 324 328 330 336 340 341 345 347 372 375 407 409 411 416 424 426 433 436 437 445 466 500 534
Monocytes	2.05e-10	28	65.116	4 15 27 31 37 61 63 65 69 73 79 82 85 86 87 92 98 99 108 114 117 119 120 121 123 124 126 128 136 138 151 169 171 173 174 175 177 179 182 197 199 208 216 223 237 243 247 248 250 254 255 259 263 264 265 267 273 280 289 292 300 303 308 312 316 317 328 340 341 345 347 358 369 375 376 378 399 403 407 411 414 433 436 439 451 456 459 466 481 488 491 500 518 522 525 531 532 537 538 539 544 562 568
Cancer tissue	6.57e-10	42	97.674	1 2 3 5 6 7 8 10 11 12 13 19 23 24 27 29 33 36 38 40 41 44 45 46 47 52 55 58 60 63 64 65 66 68 70 72 75 76 78 84 88 89 90 92 93 94 99 100 104 105 107 109 111 112 113 117 118 120 122 127 129 130 131 137 138 140 142 148 153 154 157 164 165 167 168 172 173 174 175 176 181 189 190 194 201 203 204 206 207 209 211 213 214 216 220 222 230 234 235 241 242 247 248 249 250 267 274 290 291 295 297 298 316 324 326 327 329 330 340 341 342 347 357 372 373 374 379 381 382 384 385 387 391 401 404 407 411 416 421 422 426 428 431 435 438 440 446 461 462 464 466 468 469 474 479 483 486 487 497 500 506 512 513 514 515 520 525 533 540 543 549 552 564 570 573
AML	5.93e-09	11	25.581	11 27 33 36 46 63 64 66 72 75 85 94 99 100 105 117 119 120 129 137 138 174 175 178 181 188 199 204 238 242 244 248 270 301 302 331 340 344 361 362 379 444 466 481 500 503 539 544 576
Lymphocytes	9.01e-08	28	65.116	37 57 61 65 69 70 76 79 97 119 120 126 128 136 138 145 161 169 170 171 173 174 175 179 182 188 201 204 208 210 214 216 219 237 238 241 247 250 254 255 261 267 280 289 291 292 300 301 303 308 312 313 315 316 317 328 329 330 340 341 345 347 358 361 375 378 387 399 407 433 436 439 451 456 459 466 488 512 522 525 531 532 537 554 562
Alive - B lymphoma	3.53e-07	10	23.255	37 47 69 70 79 97 120 128 136 138 145 169 170 174 175 179 182 188 201 208 214 238 241 255 261 291 292 301 317 329 345 358 361 378 387 436 459 466 512 513 525 532 562
Cancer tissue and cell line	1.14e-06	43	100	1 2 5 6 10 11 12 19 23 24 27 33 36 38 41 44 45 46 47 54 55 58 60 63 64 66 75 76 78 84 85 88 89 90 92 94 99 100 105 107 109 112 113 117 120 121 122 125 127 129 130 131 135 137 138 139 140 142 148 153 154 158 164 165 168 171 172 173 174 175 176 178 180 184 189 190 194 199 201 203 204 205 206 208 209 213 214 216 220 222 230 234 235 241 247 249 250 259 274 287 290 291 292 294 295 297 309 316 321 324 326 327 329 330 342 343 345 357 372 373 374 382 385 387 390 391 397 401 404 407 410 416 418 421 422 426 431 435 440 461 462 464 466 467 468 473 474 479 497 505 506 512 513 514 536 540 543 549 552 572 573
T cell	2.44e-06	6	13.953	5 27 45 46 60 64 75 79 97 117 120 128 138 150 156 165 170 173 174 175 182 187 240 241 261 277 289 291 292 338 345 358 398 436 466 525
Lymphoma tissue	3.90e-06	11	25.581	6 11 19 27 33 47 66 70 88 94 100 105 112 113 117 120 137 138 152 155 174 175 176 201 213 214 220 233 241 244 245 250 278 289 291 322 329 330 387 466 468 512 548
DLBCL tissue	0.00011	11	25.581	33 37 47 60 69 70 76 79 84 97 118 120 128 136 138 145 169 170 171 174 175 179 182 188 201 204 208 210 211 214 237 238 241 255 258 261 291 292 300 301 317 329 345 348 358 361 378 387 398 399 436 449 456 459 466 468 512 513 522 525 532 562
B cell	0.00017	17	39.534	27 33 37 47 57 61 63 64 65 69 70 75 76 79 85 94 97 99 102 105 113 117 119 120 124 126 128 136 138 145 146 156 169 170 173 174 175 179 182 187 188 199 201 204 208 214 216 219 237 238 240 241 244 245 247 248 250 254 255 259 261 267 289 291 292 301 308 312 313 315 316 317 328 329 330 340 341 345 347 358 361 375 378 387 399 407 411 433 436 451 456 459 466 485 502 512 522 525 532 537 554 562
DLBCL tissue and cell line	0.00018	11	25.581	33 37 47 52 61 69 70 76 79 84 97 118 120 128 136 138 145 169 170 174 175 179 182 188 201 204 208 210 211 214 237 238 241 255 258 261 291 292 300 301 317 329 345 348 358 361 378 387 398 399 436 449 456 459 466 468 512 513 522 525 532 562

Jump to: General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display

Enriched GO annotations
For each GO annotation, we tested whether it was enriched in the set of genes of the module. Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of genes in which they appear. We also show the fraction of genes with the given GO annotation that are included in this module ('Hits (%)' column).
GO annotation	P-value	Hits	Hits(%)
peripheral nervous system development	2.05e-20	6	100
central nervous system development	6.63e-11	5	83.333
neurogenesis	3.07e-10	6	100
organogenesis	6.70e-09	6	100
morphogenesis	1.18e-08	6	100
development	1.89e-07	6	100
membrane fraction	4.53e-05	4	66.666

Jump to: General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display

Visual display
Below is a visual display of the module. Shown are those arrays in which the module's genes significantly change, and the direction of change (induction/repression) in each array is indicated (middle, labeled 'Module changes'; red/green row). The arrays that correspond to the significant clinical attributes are also shown (top; brown rows). The gene sets that compose the module are also shown (left) along with an indication of the membership of the module genes in these gene sets.
You can also view the images within GeneXPress by loading the module gxp file file.
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