Module 515

Jump to: General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
General Properties
Below we list the number of gene sets from which the module was composed was originally composed, and the number of genes and experiments that it contains. Clicking on the number of genes will display a detailed list of all the genes in the module. Clicking on the number of experiments will display a detailed list of all the experiments in the module.
Num gene sets: 2
Num genes: 53 (see 222 additional genes for this module)
Num experiments: 114 (35 induced, 79 repressed)


Jump to: General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Gene sets
Below we list the gene sets from which the module was originally composed. Clicking on a gene set will display all the genes associated with that gene set. Also listed are all the other modules in which the gene set participates.
Cuadras02 24 515
Iyer99 20 515


Jump to: General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Enriched clinical annotations
For each of the clinical annotations, we tested whether it was enriched in the set of experiments in which the module is significantly induced (or repressed). Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of induced (or repressed) experiments in which they appear. We also show the fraction of experiments with the given annotation that are included in this module ('Hits (%)' column). Rows that correspond to annotations that were enriched in the induced experiments of the module have a red background, while rows corresponding to annotations enriched in the repressed experiments have a green background. For each annotation, we also list the other modules in which it was enriched.
Clinical annotation P-value Hits Hits(%) Modules
Chemo vincristine 6.70e-24 27 34.177 1 2 3 5 6 8 11 12 17 18 19 20 24 28 32 38 44 47 50 52 60 62 66 72 83 88 91 100 105 111 114 118 137 151 152 155 157 159 177 190 257 307 321 323 443 446 447 460 468 474 494 497 515 570
Chemo cisplatin 1.08e-23 26 32.911 1 2 3 5 6 8 11 12 17 18 19 20 28 32 38 44 47 50 52 60 62 66 72 83 88 91 100 105 111 114 118 137 151 152 155 157 159 177 190 257 307 321 323 443 446 460 468 474 494 497 515 570
Chemo cytoxan 5.41e-23 25 31.645 1 2 3 5 6 8 11 12 15 17 18 19 28 32 38 44 47 50 52 60 62 66 72 83 88 91 100 105 111 114 118 137 151 152 155 157 159 190 257 307 321 323 443 446 460 468 474 494 497 515 570
Medulloblastoma 2.59e-22 27 34.177 1 2 3 5 6 8 11 12 15 17 18 19 20 24 28 29 32 38 44 47 50 52 55 60 62 66 72 83 88 91 100 103 105 111 114 118 137 151 152 155 157 159 174 177 190 257 299 307 321 323 443 446 447 460 468 474 494 497 515 570
Classic Medulloblastoma 2.77e-17 20 25.316 1 2 3 5 6 8 11 12 15 17 18 19 24 32 38 44 47 52 60 66 72 83 88 100 105 111 114 118 137 151 152 155 157 159 190 321 323 443 446 447 460 468 474 494 497 515 570
CNS 9.76e-17 33 41.772 1 2 3 5 6 8 11 12 13 15 16 17 18 19 20 24 28 29 32 33 38 44 47 50 52 53 55 60 62 66 72 83 84 88 91 100 103 105 111 113 114 118 137 151 152 155 157 159 174 177 183 190 241 257 274 291 299 307 321 322 323 350 381 395 425 443 446 447 460 468 473 474 477 483 494 497 515 533 563 570
CNS tumor 1.52e-16 31 39.240 1 2 3 5 6 8 11 12 13 15 16 17 18 19 20 24 28 29 32 33 38 39 44 47 50 52 53 55 60 62 66 72 83 88 91 100 103 105 111 114 118 137 151 152 155 157 159 174 177 183 190 241 257 274 291 299 307 321 322 323 350 381 388 395 425 443 446 447 460 468 473 474 477 483 494 497 513 515 533 563 570
CNS cancer or cell line 1.46e-15 31 39.240 1 2 3 5 6 8 11 12 13 15 16 17 18 19 24 28 29 32 33 38 44 47 50 52 53 55 60 62 66 72 83 84 88 91 100 103 105 111 114 118 137 151 152 155 157 159 174 177 183 190 241 257 274 291 299 307 321 322 323 350 381 395 425 443 446 447 460 468 473 474 477 483 497 515 533 563 570
Stage T2 all - CNS 4.05e-13 10 12.658 2 6 8 12 18 38 47 118 190 321 474 497 515
Stage M1- brain 4.97e-13 16 20.253 1 2 3 5 6 8 11 12 17 18 19 28 32 38 47 52 60 66 72 83 91 100 105 111 114 118 137 151 152 155 157 159 190 321 323 443 446 447 460 474 497 515 570
Alive - Brain tumor 7.29e-13 18 22.784 1 2 3 5 6 8 11 12 15 17 18 19 24 28 32 38 44 47 50 52 60 66 72 88 91 100 105 114 118 137 151 152 155 159 174 190 241 257 274 299 321 443 446 460 474 477 483 497 515 533 563 570
Adenocarcinoma (various tissues) 2.75e-11 27 77.142 2 6 7 9 10 11 12 19 20 23 24 26 36 38 40 41 43 48 55 58 60 66 67 68 78 83 88 89 90 92 93 94 95 96 100 101 104 106 107 108 112 113 117 122 129 130 131 135 137 139 140 142 143 148 153 154 157 162 163 164 165 166 167 172 176 180 181 189 190 192 203 204 205 206 207 209 211 220 221 222 223 230 234 235 239 242 249 257 258 263 279 280 285 286 290 293 295 297 298 306 310 322 324 326 334 342 343 357 364 373 374 379 382 384 385 389 397 401 404 417 421 422 426 427 431 435 438 440 443 447 461 464 469 479 480 486 487 495 506 513 514 515 520 521 523 542 551 552 564 567 573
HCC 3.80e-11 15 42.857 3 8 9 10 15 16 17 18 19 23 24 27 40 41 43 44 47 48 49 52 53 54 55 57 58 63 64 67 72 76 78 88 90 92 93 95 98 99 101 106 108 117 118 123 125 129 130 132 135 137 140 143 144 154 158 162 163 164 165 171 172 180 184 185 189 190 193 198 205 207 208 209 212 221 223 234 235 239 247 249 251 252 257 259 263 286 289 292 293 294 295 305 306 309 310 337 342 343 345 353 354 367 372 373 375 391 394 397 415 421 422 424 432 436 440 452 458 469 470 474 478 479 481 486 495 505 506 507 510 514 515 523 526 536 543 544 545 553 566 573
Stage M1 1.69e-10 16 20.253 1 2 3 5 6 8 11 12 17 18 19 28 32 38 47 52 66 72 83 100 105 114 118 137 151 152 155 157 159 190 321 323 443 446 460 474 497 515 570
Chemo etoposide 1.65e-09 9 11.392 1 2 3 6 8 11 12 18 19 38 47 52 60 66 72 100 118 137 159 257 321 443 446 474 497 515 570
HBV infected 5.50e-09 15 42.857 1 2 5 6 8 9 10 11 12 15 17 18 19 23 24 27 33 34 38 40 41 43 44 45 46 47 48 49 52 53 54 55 57 58 60 63 64 66 67 73 75 76 78 84 85 88 92 93 94 95 96 98 99 100 101 106 107 108 109 112 117 118 121 123 125 129 130 131 132 134 135 137 140 144 146 154 158 163 164 165 172 176 180 184 185 190 191 193 197 198 199 205 207 209 212 213 221 223 227 234 235 239 247 248 249 251 252 257 259 262 263 265 276 286 287 288 289 292 293 294 295 297 305 306 309 310 319 320 324 327 337 342 343 345 349 353 354 357 364 367 370 372 373 375 385 386 397 401 404 406 410 415 417 422 423 424 426 432 434 436 440 445 452 458 461 468 469 474 477 478 479 481 485 486 495 496 505 506 507 510 514 515 523 529 530 536 544 545 546 553 566
Hepatitis infected 1.40e-08 15 42.857 1 2 5 6 8 9 10 11 12 15 17 19 23 24 27 33 34 38 40 41 43 44 45 46 47 48 49 52 53 54 55 57 58 60 63 64 66 67 73 75 76 78 79 84 85 88 92 93 94 95 96 98 99 100 101 106 107 108 109 112 117 118 121 123 125 128 129 130 131 132 134 135 137 140 144 146 154 158 163 164 165 170 171 172 176 180 184 185 190 191 193 197 198 199 205 207 208 209 212 213 221 223 227 234 235 239 247 248 249 251 252 257 259 262 263 265 276 286 287 288 289 292 293 294 295 297 305 306 309 310 319 320 324 327 337 342 343 345 349 353 354 357 364 367 370 372 373 375 385 386 397 401 404 406 410 415 417 422 423 424 426 434 436 440 445 452 458 461 468 469 474 477 478 479 481 485 486 495 496 505 506 507 510 514 515 523 529 530 536 544 545 546 553 564 566
Liver tissue 2.10e-08 16 45.714 1 2 3 5 6 8 9 10 11 12 15 16 17 18 19 23 24 26 27 33 34 38 40 41 43 44 45 46 47 48 49 52 53 54 55 57 58 60 63 64 66 67 73 75 76 78 79 84 85 88 92 93 94 95 96 98 99 100 101 106 107 108 109 112 117 118 121 122 123 125 128 129 130 131 132 134 135 137 139 140 143 146 154 158 162 163 164 165 170 171 172 176 180 184 185 186 190 191 193 197 198 199 205 207 208 209 212 213 220 221 223 227 234 235 236 239 247 248 249 251 252 253 257 259 262 263 265 286 287 288 289 292 293 294 295 297 305 306 309 310 315 320 321 324 327 335 337 342 343 345 349 353 354 357 364 367 370 372 373 375 385 386 397 401 404 405 406 410 415 417 422 423 424 426 432 434 436 437 440 445 452 458 461 468 469 474 477 478 479 481 484 485 486 495 496 505 506 507 510 514 515 523 528 529 530 536 544 545 546 553 556 564 566
Liver tissue or cell line 4.53e-08 16 45.714 1 2 3 5 6 8 9 10 11 12 15 16 17 18 19 23 24 27 33 34 38 40 41 43 44 45 46 47 48 49 52 53 54 55 57 58 60 63 64 66 67 72 73 75 76 78 79 84 85 88 92 93 94 95 96 98 99 100 101 106 107 108 109 112 117 118 121 122 123 125 128 129 130 131 132 134 135 137 139 140 146 154 158 162 163 164 165 170 171 172 176 180 184 185 186 190 191 193 197 198 199 205 207 208 209 212 213 220 221 223 227 234 235 236 239 247 248 249 250 251 252 253 257 259 262 263 265 283 286 287 288 289 292 293 294 295 297 305 306 309 310 315 320 321 324 327 335 337 342 343 345 349 353 354 357 364 367 370 372 373 375 385 386 397 401 402 404 405 406 410 415 417 422 423 424 426 432 434 436 437 440 445 452 454 457 458 461 468 469 474 477 478 479 481 484 486 495 496 505 506 507 510 514 515 523 528 529 530 536 544 545 546 553 556 564 566
p53 positive HCC 6.28e-08 7 20 3 8 9 15 16 17 18 27 32 40 43 48 52 53 54 57 72 78 93 95 98 99 106 117 118 124 125 129 135 140 158 163 165 180 198 212 234 235 239 249 252 305 337 343 354 372 397 415 422 457 481 495 506 515 544
invasive liver tumor 1.51e-07 8 22.857 3 8 9 15 16 17 18 23 27 40 43 48 49 52 53 54 55 57 64 72 78 93 95 98 99 105 106 107 108 109 117 118 124 125 126 129 131 135 140 144 146 158 163 164 172 180 184 190 198 205 209 212 221 223 234 235 239 244 247 249 252 257 263 287 294 295 302 305 306 320 337 342 343 354 364 372 373 375 397 417 422 424 432 440 452 458 469 474 478 479 481 486 495 505 506 515 523 536 544 545 573
Dead - Brain tumor 3.63e-07 12 15.189 1 2 3 5 6 8 11 12 13 18 19 28 32 38 47 60 62 66 72 83 91 100 111 114 118 137 151 152 159 167 274 307 321 381 388 438 446 447 477 483 497 515 533 563 570
Despoplastic Medulloblastoma 3.68e-07 7 8.860 3 8 12 18 28 50 72 91 100 152 321 443 460 497 515
Stage T3 - CNS 5.93e-06 8 10.126 1 2 3 5 8 11 12 15 17 18 19 28 32 38 47 50 52 66 72 83 91 100 105 111 114 118 137 151 152 155 157 159 190 321 323 443 446 460 474 497 515 570
Stage T2 all 2.60e-05 11 13.924 139 153 154 180 192 279 297 334 357 382 401 427 461 480 486 497 515
Alive - all 5.18e-05 19 24.050 26 70 169 201 206 207 214 261 321 329 387 389 460 497 512 513 515 525 562 567
Fast doubling (20-40) cell lines 0.00017 12 15.189 1 2 5 6 11 12 14 15 19 23 24 33 38 44 45 46 47 55 60 66 75 79 84 88 100 112 119 122 128 137 139 154 170 176 178 180 213 220 227 292 297 321 335 342 357 362 418 426 444 455 474 491 492 493 505 507 513 515 516 549 568
Cancer tissue 0.00023 30 85.714 1 2 3 5 6 7 8 10 11 12 13 19 23 24 27 29 33 36 38 40 41 44 45 46 47 52 55 58 60 63 64 65 66 68 70 72 75 76 78 84 88 89 90 92 93 94 99 100 104 105 107 109 111 112 113 117 118 120 122 127 129 130 131 137 138 140 142 148 153 154 157 164 165 167 168 172 173 174 175 176 181 189 190 194 201 203 204 206 207 209 211 213 214 216 220 222 230 234 235 241 242 247 248 249 250 267 274 290 291 295 297 298 316 324 326 327 329 330 340 341 342 347 357 372 373 374 379 381 382 384 385 387 391 401 404 407 411 416 421 422 426 428 431 435 438 440 446 461 462 464 466 468 469 474 479 483 486 487 497 500 506 512 513 514 515 520 525 533 540 543 549 552 564 570 573
Stage T4 - CNS 0.00026 4 5.063 446 497 515


Jump to: General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Enriched GO annotations
For each GO annotation, we tested whether it was enriched in the set of genes of the module. Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of genes in which they appear. We also show the fraction of genes with the given GO annotation that are included in this module ('Hits (%)' column).


Jump to: General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Visual display
Below is a visual display of the module. Shown are those arrays in which the module's genes significantly change, and the direction of change (induction/repression) in each array is indicated (middle, labeled 'Module changes'; red/green row). The arrays that correspond to the significant clinical attributes are also shown (top; brown rows). The gene sets that compose the module are also shown (left) along with an indication of the membership of the module genes in these gene sets.
You can also view the images within GeneXPress by loading the module gxp file file.
 
 





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