Module 520

Jump to: General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
General Properties
Below we list the number of gene sets from which the module was composed was originally composed, and the number of genes and experiments that it contains. Clicking on the number of genes will display a detailed list of all the genes in the module. Clicking on the number of experiments will display a detailed list of all the experiments in the module.
Num gene sets: 2
Num genes: 9 (see 125 additional genes for this module)
Num experiments: 37 (25 induced, 12 repressed)


Jump to: General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Gene sets
Below we list the gene sets from which the module was originally composed. Clicking on a gene set will display all the genes associated with that gene set. Also listed are all the other modules in which the gene set participates.
Pentose Phosphate Pathway 520
disulfide oxidoreductase activity 520


Jump to: General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Enriched clinical annotations
For each of the clinical annotations, we tested whether it was enriched in the set of experiments in which the module is significantly induced (or repressed). Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of induced (or repressed) experiments in which they appear. We also show the fraction of experiments with the given annotation that are included in this module ('Hits (%)' column). Rows that correspond to annotations that were enriched in the induced experiments of the module have a red background, while rows corresponding to annotations enriched in the repressed experiments have a green background. For each annotation, we also list the other modules in which it was enriched.
Clinical annotation P-value Hits Hits(%) Modules
Lung 4.04e-14 21 84 1 2 5 6 7 8 10 11 12 17 19 21 23 24 33 34 36 38 40 41 44 45 46 52 55 56 58 60 66 68 72 75 76 84 88 89 90 92 93 94 100 104 105 107 108 109 112 113 118 119 121 122 127 129 130 131 137 139 142 148 153 154 164 165 167 168 172 176 180 181 189 190 191 194 203 204 209 210 213 220 222 223 230 234 235 242 262 263 275 290 297 298 310 311 322 324 326 327 342 357 373 374 376 379 382 384 385 390 391 392 401 404 416 421 426 428 431 435 438 450 461 462 464 465 467 468 469 471 473 479 486 487 513 514 520 533 538 540 542 543 549 551 552 556 564 573
Lung cancer and cell line 5.15e-14 20 80 1 2 5 6 7 10 11 12 19 23 24 33 34 36 38 40 41 44 45 46 52 55 58 60 64 66 68 72 75 76 84 88 89 92 93 94 100 104 107 108 109 112 113 118 119 121 122 129 130 131 137 139 142 148 153 154 164 165 167 168 171 172 176 180 181 190 191 194 203 204 209 210 213 220 222 223 230 234 235 242 262 263 275 290 297 298 310 322 324 326 327 342 357 373 374 379 382 384 385 390 391 392 401 404 416 426 428 431 435 438 461 462 464 465 467 468 469 471 473 479 486 487 513 514 520 533 540 542 543 549 551 552 564 573
NSCLC tumor and cell line 5.68e-14 19 76 1 2 5 6 7 10 11 12 19 23 24 33 36 38 41 44 45 46 52 55 58 60 66 68 72 75 76 84 88 89 92 93 94 100 104 107 108 109 112 113 121 122 129 130 131 137 139 142 148 153 154 164 165 167 168 172 176 180 181 194 203 204 209 213 220 222 223 230 234 235 242 262 263 275 290 297 298 310 322 324 326 327 342 357 373 374 379 382 384 385 390 392 401 404 426 428 431 435 438 461 462 464 465 467 468 469 471 486 487 514 520 533 542 543 549 551 552 564 573
NSCLC tumor 2.89e-13 18 72 1 2 5 6 7 10 11 12 19 23 24 33 34 36 38 41 44 45 46 52 55 58 60 66 68 72 75 76 84 88 89 90 92 93 94 100 104 107 108 109 112 113 118 121 122 129 130 131 137 139 142 148 153 154 164 165 167 168 172 176 180 181 190 191 194 203 204 209 210 213 220 222 223 230 234 235 242 262 263 275 290 297 298 310 322 324 326 327 342 357 372 373 374 379 382 384 385 392 401 404 426 428 431 435 438 461 462 464 465 467 468 469 471 486 487 514 520 533 542 543 551 552 564 573
Lung cancer 3.14e-13 19 76 1 2 5 6 7 8 10 11 12 19 23 24 33 34 36 38 40 41 44 45 46 52 55 58 60 64 66 68 72 75 76 84 88 89 92 93 94 100 104 107 108 109 112 113 118 121 122 129 130 131 137 139 142 148 153 154 164 165 167 168 172 176 180 181 190 191 194 203 204 209 210 213 220 222 223 230 234 235 242 262 263 275 280 290 297 298 310 311 322 324 326 327 342 357 373 374 379 382 384 385 390 391 392 401 404 416 426 428 431 435 438 461 462 464 465 467 468 469 471 473 479 486 487 513 514 520 533 540 542 543 549 551 552 564 573
Adenocarcinoma (lung) 1.22e-10 15 60 1 2 6 7 8 11 12 19 23 24 33 36 38 41 52 54 55 60 66 68 72 76 84 88 89 90 92 93 94 100 104 107 108 109 112 113 118 121 122 129 130 137 139 142 148 153 154 164 165 167 168 172 176 180 181 194 203 204 209 213 220 222 230 234 235 242 263 275 290 297 298 310 322 324 326 342 357 372 373 374 379 382 384 385 401 404 421 426 431 435 438 461 462 464 465 468 471 486 487 514 520 533 540 542 543 549 551 552 564 573
Stage T1 4.84e-10 13 52 1 2 5 6 7 8 10 11 12 17 19 23 24 33 34 36 38 40 41 44 45 46 52 54 55 58 60 66 68 72 75 76 84 88 89 90 92 93 94 100 104 107 108 109 112 113 118 119 121 122 129 130 131 137 139 142 143 148 153 154 164 165 167 168 171 172 176 180 181 191 194 203 204 209 213 220 222 223 230 234 235 242 262 263 290 297 298 309 310 311 322 324 326 327 342 357 372 373 374 379 381 382 384 385 390 391 401 404 416 421 426 431 435 438 461 462 464 465 467 468 473 487 513 514 520 533 538 540 542 543 549 551 552 564 573
Stage T1 - lung 4.84e-10 13 52 1 2 5 6 7 8 10 11 12 17 19 23 24 33 34 36 38 40 41 44 45 46 52 54 55 58 60 66 68 72 75 76 84 88 89 90 92 93 94 100 104 107 108 109 112 113 118 119 121 122 129 130 131 137 139 142 143 148 153 154 164 165 167 168 171 172 176 180 181 191 194 203 204 209 213 220 222 223 230 234 235 242 262 263 290 297 298 309 310 311 322 324 326 327 342 357 372 373 374 379 381 382 384 385 390 391 401 404 416 421 426 431 435 438 461 462 464 465 467 468 473 487 513 514 520 533 538 540 542 543 549 551 552 564 573
Stage T1 all - lung 5.75e-09 13 52 1 2 5 6 7 8 10 11 12 17 19 23 24 33 36 38 40 41 44 45 46 52 54 55 58 60 66 68 72 75 76 84 88 89 90 92 93 94 100 104 107 108 109 112 113 118 121 122 129 130 131 137 139 142 148 153 154 164 165 167 168 172 176 180 181 190 194 203 204 209 213 220 222 223 230 234 235 242 262 263 266 290 297 298 310 311 322 324 326 327 342 357 372 373 374 379 381 382 384 385 390 391 392 401 404 416 421 426 431 435 438 461 462 464 465 467 468 471 473 487 513 514 520 533 538 540 542 543 549 551 552 564 573
Stage T1 all 1.18e-08 13 52 1 2 5 6 7 8 10 11 12 17 19 23 24 33 36 38 40 41 44 45 46 52 55 58 60 66 68 72 75 76 84 88 89 90 92 93 94 100 104 107 108 109 112 113 118 121 122 129 130 131 137 139 142 148 153 154 164 165 167 168 172 176 180 181 190 194 203 204 209 213 220 222 223 230 234 235 242 263 266 290 297 298 310 311 322 324 326 327 342 357 372 373 374 379 381 382 384 385 390 391 392 401 404 416 421 426 431 435 438 461 462 464 465 467 468 471 473 487 513 514 520 533 540 542 543 549 551 552 564 573
Adenocarcinoma (various tissues) 1.98e-05 16 64 2 6 7 9 10 11 12 19 20 23 24 26 36 38 40 41 43 48 55 58 60 66 67 68 78 83 88 89 90 92 93 94 95 96 100 101 104 106 107 108 112 113 117 122 129 130 131 135 137 139 140 142 143 148 153 154 157 162 163 164 165 166 167 172 176 180 181 189 190 192 203 204 205 206 207 209 211 220 221 222 223 230 234 235 239 242 249 257 258 263 279 280 285 286 290 293 295 297 298 306 310 322 324 326 334 342 343 357 364 373 374 379 382 384 385 389 397 401 404 417 421 422 426 427 431 435 438 440 443 447 461 464 469 479 480 486 487 495 506 513 514 515 520 521 523 542 551 552 564 567 573
Cancer tissue 0.00012 23 92 1 2 3 5 6 7 8 10 11 12 13 19 23 24 27 29 33 36 38 40 41 44 45 46 47 52 55 58 60 63 64 65 66 68 70 72 75 76 78 84 88 89 90 92 93 94 99 100 104 105 107 109 111 112 113 117 118 120 122 127 129 130 131 137 138 140 142 148 153 154 157 164 165 167 168 172 173 174 175 176 181 189 190 194 201 203 204 206 207 209 211 213 214 216 220 222 230 234 235 241 242 247 248 249 250 267 274 290 291 295 297 298 316 324 326 327 329 330 340 341 342 347 357 372 373 374 379 381 382 384 385 387 391 401 404 407 411 416 421 422 426 428 431 435 438 440 446 461 462 464 466 468 469 474 479 483 486 487 497 500 506 512 513 514 515 520 525 533 540 543 549 552 564 570 573
Normal prostate 0.00025 4 33.333 5 6 7 13 15 16 17 20 22 23 24 25 28 29 32 38 41 42 43 44 50 53 60 62 68 74 77 81 83 84 91 93 96 103 104 106 111 113 114 115 116 118 144 146 149 150 151 152 157 159 181 183 190 201 202 217 220 242 273 298 299 304 307 323 342 355 363 379 387 416 419 429 447 494 512 519 520 521 524 542 564


Jump to: General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Enriched GO annotations
For each GO annotation, we tested whether it was enriched in the set of genes of the module. Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of genes in which they appear. We also show the fraction of genes with the given GO annotation that are included in this module ('Hits (%)' column).
GO annotation P-value Hits Hits(%)
disulfide oxidoreductase activity 3.04e-15 6 66.666
oxidoreductase activity 5.10e-09 7 77.777
protein disulfide oxidoreductase activity 3.55e-08 3 33.333
electron transport 4.78e-07 5 55.555
photosynthesis 1.41e-06 5 55.555
energy pathways 3.11e-06 5 55.555
catalytic activity 3.81e-06 9 100
electron transporter activity 1.46e-05 5 55.555


Jump to: General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Visual display
Below is a visual display of the module. Shown are those arrays in which the module's genes significantly change, and the direction of change (induction/repression) in each array is indicated (middle, labeled 'Module changes'; red/green row). The arrays that correspond to the significant clinical attributes are also shown (top; brown rows). The gene sets that compose the module are also shown (left) along with an indication of the membership of the module genes in these gene sets.
You can also view the images within GeneXPress by loading the module gxp file file.
 
 





 >4x