Module 554

Jump to: General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display

General Properties
Below we list the number of gene sets from which the module was composed was originally composed, and the number of genes and experiments that it contains. Clicking on the number of genes will display a detailed list of all the genes in the module. Clicking on the number of experiments will display a detailed list of all the experiments in the module.
Num gene sets:	2
Num genes:	20 (see 8 additional genes for this module)
Num experiments:	52 (18 induced, 34 repressed)

Jump to: General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display

Gene sets
Below we list the gene sets from which the module was originally composed. Clicking on a gene set will display all the genes associated with that gene set. Also listed are all the other modules in which the gene set participates.
Ross01 16	554
Iyer99 38	554

Jump to: General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display

Enriched clinical annotations
For each of the clinical annotations, we tested whether it was enriched in the set of experiments in which the module is significantly induced (or repressed). Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of induced (or repressed) experiments in which they appear. We also show the fraction of experiments with the given annotation that are included in this module ('Hits (%)' column). Rows that correspond to annotations that were enriched in the induced experiments of the module have a red background, while rows corresponding to annotations enriched in the repressed experiments have a green background. For each annotation, we also list the other modules in which it was enriched.
Clinical annotation	P-value	Hits	Hits(%)	Modules
CLL	1.87e-15	14	41.176	3 5 8 16 17 18 21 37 52 53 54 56 57 61 64 69 72 76 79 84 97 98 102 105 118 119 124 125 126 128 136 145 156 158 161 169 170 171 179 182 187 188 197 198 210 212 219 236 237 238 240 244 245 252 254 255 258 261 292 300 301 302 303 308 312 313 315 317 337 344 345 348 358 361 378 399 403 436 451 456 459 485 502 513 522 525 531 532 537 547 554 562 573
B cell	1.71e-10	22	64.705	27 33 37 47 57 61 63 64 65 69 70 75 76 79 85 94 97 99 102 105 113 117 119 120 124 126 128 136 138 145 146 156 169 170 173 174 175 179 182 187 188 199 201 204 208 214 216 219 237 238 240 241 244 245 247 248 250 254 255 259 261 267 289 291 292 301 308 312 313 315 316 317 328 329 330 340 341 345 347 358 361 375 378 387 399 407 411 433 436 451 456 459 466 485 502 512 522 525 532 537 554 562
No Ig mut	1.23e-07	6	17.647	16 37 53 54 57 61 69 79 98 118 119 124 126 128 136 145 156 169 170 179 187 188 237 238 240 254 255 258 301 308 312 313 315 317 361 378 399 403 451 456 459 485 502 525 532 537 554
Leukemia tissue or cell line	5.93e-07	15	44.117	1 2 3 5 6 8 11 12 24 27 33 38 44 45 46 47 52 55 57 61 63 64 65 66 75 76 79 84 85 88 92 94 99 100 102 105 112 117 118 119 120 122 124 126 128 129 137 138 145 156 165 169 170 173 174 175 176 178 187 188 199 204 208 216 219 220 237 238 240 241 244 247 248 250 254 259 267 287 289 291 292 300 301 302 308 312 313 315 316 324 328 330 331 340 341 344 345 347 361 362 375 399 403 407 411 416 424 433 436 437 445 451 456 466 485 500 502 503 534 537 539 554 576
Bp338	1.39e-06	6	33.333	37 46 61 69 75 92 97 119 121 126 136 161 171 179 182 208 223 254 255 261 292 303 308 312 317 336 345 358 378 433 436 456 459 488 522 525 532 554
Blood cancer	1.49e-06	19	55.882	1 5 11 27 33 37 46 47 61 63 64 65 66 69 70 75 79 85 94 97 99 100 102 105 112 117 119 120 124 128 129 136 138 145 169 170 173 174 175 176 178 179 182 188 199 201 204 214 216 219 237 238 241 244 245 247 248 250 254 255 261 267 277 289 291 301 308 312 313 315 316 317 328 329 330 340 341 345 347 358 361 375 378 387 407 411 416 433 451 456 459 466 500 502 512 525 532 537 539 554 562
Leukemia tissue	1.70e-06	14	41.176	1 2 3 5 8 11 12 24 27 33 44 45 46 47 52 54 57 61 63 64 65 66 75 76 79 84 85 88 92 94 99 100 102 105 112 117 118 119 120 124 126 128 129 137 138 145 156 165 169 170 171 173 174 175 176 178 187 188 197 199 204 208 216 219 237 238 240 241 244 247 248 250 254 259 267 287 289 291 292 300 301 302 308 312 313 315 316 324 328 330 331 340 341 344 345 347 361 375 399 403 407 411 416 424 433 436 437 445 451 456 466 485 500 502 503 534 537 539 554 576
Lymphocytes	2.74e-06	22	64.705	37 57 61 65 69 70 76 79 97 119 120 126 128 136 138 145 161 169 170 171 173 174 175 179 182 188 201 204 208 210 214 216 219 237 238 241 247 250 254 255 261 267 280 289 291 292 300 301 303 308 312 313 315 316 317 328 329 330 340 341 345 347 358 361 375 378 387 399 407 433 436 439 451 456 459 466 488 512 522 525 531 532 537 554 562
Lymphocytes	7.45e-06	14	77.777	37 57 61 65 69 70 76 79 97 119 120 126 128 136 138 145 161 169 170 171 173 174 175 179 182 188 201 204 208 210 214 216 219 237 238 241 247 250 254 255 261 267 280 289 291 292 300 301 303 308 312 313 315 316 317 328 329 330 340 341 345 347 358 361 375 378 387 399 407 433 436 439 451 456 459 466 488 512 522 525 531 532 537 554 562
High Ig mut CLL	1.49e-05	4	11.764	16 18 37 53 54 57 61 69 79 98 102 105 119 124 126 128 136 145 161 169 170 179 188 198 210 212 219 238 252 254 255 261 292 301 308 312 315 317 344 361 378 451 456 459 485 502 531 532 537 554
Stimulate immune cells	1.57e-05	8	44.444	5 15 31 37 46 61 64 69 75 76 79 84 92 97 108 119 121 123 124 126 128 136 161 169 170 171 174 179 182 208 223 237 254 255 261 263 280 289 292 300 301 303 308 312 317 345 358 369 375 376 378 399 433 436 439 456 459 481 488 521 522 525 531 532 537 538 541 544 554 562
B. petrussis	1.73e-05	6	33.333	15 16 17 18 31 37 46 53 54 57 61 69 72 73 75 79 92 97 105 118 119 121 124 126 128 136 143 145 161 170 171 179 182 188 197 198 208 210 212 219 223 237 238 244 252 254 255 261 280 292 293 300 301 303 308 312 315 317 345 358 361 367 376 378 399 403 433 436 439 451 456 459 485 488 521 522 525 532 537 538 541 554
Blood cancer and cell line	2.19e-05	20	58.823	4 5 15 16 17 21 27 31 33 37 46 47 56 57 61 63 64 65 69 70 75 76 79 82 84 85 86 87 94 97 98 99 102 105 114 117 119 120 124 125 126 128 136 138 145 151 158 161 169 170 171 173 174 175 177 178 179 182 188 198 199 201 204 208 214 216 219 233 237 238 241 243 244 245 247 248 250 252 254 255 259 261 265 267 273 277 278 289 291 292 300 301 303 308 312 313 315 316 317 328 329 330 332 340 341 344 345 347 358 361 375 376 378 387 399 403 407 411 433 436 442 451 456 459 466 485 490 491 500 502 512 518 522 525 532 537 539 554 562 568
Rai=0	4.69e-05	3	8.823	57 61 98 102 124 126 145 169 188 198 212 219 238 252 254 301 308 312 315 361 456 554
Rai=1	9.28e-05	3	8.823	61 126 145 156 169 187 188 238 240 254 301 308 312 344 361 399 456 485 502 513 554
Rai=2	9.28e-05	3	8.823	57 119 126 145 169 188 238 254 301 308 312 315 348 358 361 399 451 456 537 554
Live bacteria	0.00024	4	22.222	3 4 6 8 9 15 16 17 18 22 27 28 32 39 42 44 46 48 50 52 53 62 64 73 74 75 76 77 79 82 83 84 86 87 91 95 98 108 114 116 118 121 123 126 151 152 159 163 165 169 177 197 198 212 223 226 243 254 263 264 265 273 275 280 281 307 309 311 312 319 323 336 346 352 363 371 414 449 456 477 479 488 491 494 518 537 550 554 562 568 574
Gram negative	0.00026	6	33.333	3 4 5 8 15 16 17 18 27 37 44 45 46 52 53 54 57 61 64 69 73 74 75 76 79 82 84 86 87 92 97 98 108 114 116 118 119 121 123 124 126 128 136 151 169 170 171 177 179 182 197 198 208 210 212 223 237 244 252 254 255 259 261 263 265 273 280 289 292 293 300 308 312 315 317 321 345 358 371 378 399 403 414 433 436 439 449 451 456 459 485 488 491 518 521 522 525 532 537 538 541 550 554 562 568
Blood and blood cells	0.00027	8	44.444	37 46 61 64 69 75 76 79 84 92 97 108 119 121 126 128 136 143 161 169 170 171 174 179 182 208 210 223 241 254 255 261 263 280 291 292 300 303 312 317 345 358 375 378 399 433 436 439 449 456 459 481 488 521 522 525 531 532 537 541 544 554 562
PBMC	0.00034	8	44.444	37 46 64 69 75 79 84 92 97 108 119 121 128 136 161 169 170 171 174 179 182 208 210 216 223 254 255 261 263 280 292 300 303 308 312 317 345 358 369 375 376 378 399 433 436 439 456 459 481 488 521 522 525 531 532 537 541 544 554 562

Jump to: General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display

Enriched GO annotations

For each GO annotation, we tested whether it was enriched in the set of genes of the module. Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of genes in which they appear. We also show the fraction of genes with the given GO annotation that are included in this module ('Hits (%)' column).

Jump to: General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display

Visual display
Below is a visual display of the module. Shown are those arrays in which the module's genes significantly change, and the direction of change (induction/repression) in each array is indicated (middle, labeled 'Module changes'; red/green row). The arrays that correspond to the significant clinical attributes are also shown (top; brown rows). The gene sets that compose the module are also shown (left) along with an indication of the membership of the module genes in these gene sets.
You can also view the images within GeneXPress by loading the module gxp file file.
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