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 >4x |
Module 572 |
| General Properties | |
|---|---|
| Below we list the number of gene sets from which the module was composed was originally composed, and the number of genes and experiments that it contains. Clicking on the number of genes will display a detailed list of all the genes in the module. Clicking on the number of experiments will display a detailed list of all the experiments in the module. | |
| Num gene sets: | 2 |
| Num genes: | 10 (see 242 additional genes for this module) |
| Num experiments: | 109 (73 induced, 36 repressed) |
| Gene sets | |
|---|---|
| Below we list the gene sets from which the module was originally composed. Clicking on a gene set will display all the genes associated with that gene set. Also listed are all the other modules in which the gene set participates. | |
| DNA replication initiation | 572 |
| DNA replication factor C complex | 572 |
| Enriched clinical annotations | ||||
|---|---|---|---|---|
| For each of the clinical annotations, we tested whether it was enriched in the set of experiments in which the module is significantly induced (or repressed). Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of induced (or repressed) experiments in which they appear. We also show the fraction of experiments with the given annotation that are included in this module ('Hits (%)' column). Rows that correspond to annotations that were enriched in the induced experiments of the module have a red background, while rows corresponding to annotations enriched in the repressed experiments have a green background. For each annotation, we also list the other modules in which it was enriched. | ||||
| Clinical annotation | P-value | Hits | Hits(%) | Modules |
| EWS/FLI | 3.75e-07 | 5 | 13.888 | 41 94 104 124 125 158 167 244 283 302 315 320 344 372 397 403 438 485 533 572 |
| Cancer tissue and cell line | 1.04e-05 | 68 | 93.150 | 1 2 5 6 10 11 12 19 23 24 27 33 36 38 41 44 45 46 47 54 55 58 60 63 64 66 75 76 78 84 85 88 89 90 92 94 99 100 105 107 109 112 113 117 120 121 122 125 127 129 130 131 135 137 138 139 140 142 148 153 154 158 164 165 168 171 172 173 174 175 176 178 180 184 189 190 194 199 201 203 204 205 206 208 209 213 214 216 220 222 230 234 235 241 247 249 250 259 274 287 290 291 292 294 295 297 309 316 321 324 326 327 329 330 342 343 345 357 372 373 374 382 385 387 390 391 397 401 404 407 410 416 418 421 422 426 431 435 440 461 462 464 466 467 468 473 474 479 497 505 506 512 513 514 536 540 543 549 552 572 573 |
| Liver cell line | 1.37e-05 | 5 | 6.849 | 1 3 9 10 17 18 19 23 24 27 32 38 40 43 44 45 46 48 49 52 54 57 58 60 63 64 72 73 75 76 78 79 93 95 96 98 99 101 106 107 108 109 112 117 118 119 121 123 124 125 126 128 129 130 131 132 135 139 158 163 164 165 167 169 170 171 172 176 177 180 184 185 198 199 205 208 209 212 213 221 223 235 238 244 246 247 249 252 258 259 263 265 283 286 292 294 295 301 302 305 309 310 320 327 337 342 343 345 349 353 373 388 395 397 401 403 410 415 416 418 424 426 430 436 438 440 443 451 454 456 457 458 461 462 467 477 478 479 496 505 529 536 556 572 |
| Centroblasts | 2.54e-05 | 4 | 5.479 | 80 107 315 332 403 485 572 |
| Skin | 8.21e-05 | 6 | 16.666 | 197 302 318 320 394 432 488 509 510 572 |
| Fibroblasts | 9.42e-05 | 6 | 16.666 | 197 302 318 320 394 432 509 510 572 |
| SMCL | 0.00031 | 4 | 5.479 | 40 54 57 68 92 93 104 107 109 121 122 125 127 131 139 148 153 154 158 164 172 180 181 198 209 230 235 242 252 297 298 302 320 324 326 327 341 342 344 357 372 379 381 390 403 431 451 462 543 572 |
| Enriched GO annotations | ||||
|---|---|---|---|---|
| For each GO annotation, we tested whether it was enriched in the set of genes of the module. Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of genes in which they appear. We also show the fraction of genes with the given GO annotation that are included in this module ('Hits (%)' column). | ||||
| GO annotation | P-value | Hits | Hits(%) | |
| DNA replication | 1.93e-18 | 9 | 90 | |
| S phase of mitotic cell cycle | 1.66e-15 | 7 | 70 | |
| DNA dependent DNA replication | 2.58e-15 | 7 | 70 | |
| DNA replication and chromosome cycle | 3.90e-15 | 7 | 70 | |
| DNA metabolism | 1.01e-13 | 9 | 90 | |
| DNA replication initiation | 7.70e-13 | 5 | 50 | |
| replisome | 7.70e-13 | 5 | 50 | |
| DNA replication factor C complex | 6.43e-12 | 4 | 40 | |
| chromosome | 2.23e-07 | 5 | 50 | |
| nucleotide binding | 2.38e-07 | 8 | 80 | |
| DNA binding | 4.37e-07 | 7 | 70 | |
| nucleus | 8.05e-07 | 9 | 90 | |
| endomembrane system | 1.09e-06 | 9 | 90 | |
| ATP binding | 1.23e-06 | 7 | 70 | |
| cell cycle | 1.68e-06 | 5 | 50 | |
| transcription regulator activity | 2.83e-05 | 7 | 70 | |
| Visual display | |||||||||
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| Below is a visual display of the module. Shown are those arrays in which the module's genes significantly change, and the direction of change (induction/repression) in each array is indicated (middle, labeled 'Module changes'; red/green row). The arrays that correspond to the significant clinical attributes are also shown (top; brown rows). The gene sets that compose the module are also shown (left) along with an indication of the membership of the module genes in these gene sets. | |||||||||
| You can also view the images within GeneXPress by loading the module gxp file file. | |||||||||
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