My home page
My group
Professional activities

Daphne Koller Publications

Decomposing gene expression into cellular processes (2003)

by E. Segal, A.J. Battle, and D. Koller

Abstract: We propose a probabilistic model for cellular processes, and an algorithm for discovering them from gene expression data. A process is associated with a set of genes that participate in it; unlike clustering techniques, our model allows genes to participate in multiple processes. Each process may be active to a different degree in each experiment. The expression measurement for gene g in array a is a sum, over all processes in which g participates, of the activity levels of these processes in array a. We describe an iterative procedure, based on the EM algorithm, for decomposing the expression matrix into a given number of processes. We present results on Yeast gene expression data, which indicate that our approach identifies real biological processes.

Download Information

E. Segal, A.J. Battle, and D. Koller (2003). "Decomposing gene expression into cellular processes." Proc. Pacific Symposium on Biocomputing (PSB) (pp. 89-100). pdf ps.gz

Bibtex citation

  title = {Decomposing gene expression into cellular processes}, 
  author = {E. Segal and A.J. Battle and D. Koller},
  booktitle = {Proc. Pacific Symposium on Biocomputing (PSB)}, 
  month = {January},
  year = {2003},
  editors = {R.B. Altman and A.K. Dunkner and L. Hunter and T.A. Jung and T.E. Klein},
  publisher = {World Scientific}, 
  pages = {89--100},

full list
Click to go to robotics Click to go to theory Click to go to CS Stanford Click to go to Stanford's Webpage
home | biography | research | papers | my group
courses | professional activities | FAQ | personal