Module 273 -- Phosphate metabolism

General Properties
Below we list the number of gene sets from which the module was composed was originally composed, and the number of genes and experiments that it contains. Clicking on the number of genes will display a detailed list of all the genes in the module. Clicking on the number of experiments will display a detailed list of all the experiments in the module.
Num gene sets:	2
Num genes:	52 (see 1962 additional genes for this module)
Num experiments:	128 (44 induced, 84 repressed)
Parent module:	363
Children modules:	None

Gene sets
Below we list the gene sets from which the module was originally composed. Clicking on a gene set will display all the genes associated with that gene set. Also listed are all the other modules in which the gene set participates.
phosphorus metabolism
phosphate metabolism

Enriched clinical annotations
For each of the clinical annotations, we tested whether it was enriched in the set of arrays in which the module is significantly induced (or repressed). Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of induced (or repressed) module's arrays in which they appear. We also show the fraction of the module's induced (or repressed) arrays with the given annotation ('Hits (%)' column). For completeness, we also list the total number of relevant induced arrays in the module ('Module hits in category' column), total number of arrays in the compendium in which the corresponding annotation is present ('Arrays in annotation' column), and the total number of relevant arrays in the compendium ('Arrays' column). Note that the 'relevant' arrays may be different for each annotation, since it includes only arrays in which the annotation was relevant (i.e., present or not present) and excludes arrays where the value of the annotation was not known. Rows that correspond to annotations that were enriched in the induced arrays of the module have a red background, while rows corresponding to annotations enriched in the repressed arrays have a green background. For each annotation, we also list the other modules in which it was enriched.
Clinical annotation	Category	P-value	Hits	Hits(%)	Module hits in category	Arrays in annotation	Arrays
Prostate (Prostate cancer*)	Prostate cancer*	2.8e-32	40	47.6	84	101	1945
Hematologic cancer and cell line (Stimulated immune*)	Stimulated immune*	1.9e-15	16	36.3	44	53	1945
Hematologic samples and cell lines (Stimulated immune*)	Stimulated immune*	1.9e-15	16	36.3	44	53	1945
Macrophages (Stimulated immune*)	Stimulated immune*	1.9e-15	16	36.3	44	53	1945
Monocytes (Stimulated immune*)	Stimulated immune*	1.9e-15	16	36.3	44	53	1945
Hematologic cancer and cell line (Stimulated immune*)	Stimulated immune*	1.6e-08	14	16.6	84	53	1945
Hematologic samples and cell lines (Stimulated immune*)	Stimulated immune*	1.6e-08	14	16.6	84	53	1945
Macrophages (Stimulated immune*)	Stimulated immune*	1.6e-08	14	16.6	84	53	1945
Monocytes (Stimulated immune*)	Stimulated immune*	1.6e-08	14	16.6	84	53	1945
Lung carcinoid (Lung cancer)	Lung cancer	0.0002	4	66.6	6	20	276

Enriched GO annotations
For each GO annotation, we tested whether it was enriched in the set of genes of the module. Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of the module's genes in which they appear. We also show the fraction of the module's genes with the given GO annotation that are included in this module ('Hits (%)' column). For completeness, we also list the total number of genes in the module ('Module genes' column), total number of genes in the compendium in which the corresponding annotation is present ('Genes in annotation' column), and the total number of genes in the compendium ('Genes' column).
GO annotation	P-value	Hits	Hits(%)	Module genes	Genes in annotation	Genes
phosphate metabolism	1.4e-81	52	100	52	153	4566
phosphorus metabolism	5.1e-81	51	98.0	52	138	4566
phosphorylation	1.6e-74	51	98.0	52	176	4566
monovalent inorganic cation transporter activity	6.8e-32	25	48.0	52	80	4566
transcription from Pol II promoter	5.3e-26	25	48.0	52	130	4566
sodium ion transporter activity	6.9e-26	19	36.5	52	50	4566
ion transporter activity	8.2e-25	25	48.0	52	144	4566
metal ion transporter activity	4.3e-24	19	36.5	52	60	4566
oxidative phosphorylation	2.4e-23	13	25	52	17	4566
protein-disulfide reduction	2.1e-21	12	23.0	52	16	4566
nucleoside monophosphate phosphorylation	2.1e-20	12	23.0	52	18	4566
ATP synthesis coupled electron transport (sensu Eukarya)	1.7e-19	11	21.1	52	15	4566
hydrogen ion transporter activity	1.3e-18	15	28.8	52	50	4566
mitochondrial electron transport\, NADH to ubiquinone	1.4e-17	10	19.2	52	14	4566
proton transport	8.4e-16	12	23.0	52	35	4566
mitochondrion	1.9e-14	20	38.4	52	207	4566
NADH dehydrogenase activity	4.2e-14	10	19.2	52	25	4566
NADH dehydrogenase (ubiquinone) activity	6.8e-14	10	19.2	52	26	4566
nucleotide metabolism	2.6e-12	12	23.0	52	64	4566
monovalent inorganic cation transport	3.6e-11	12	23.0	52	79	4566
mitochondrial inner membrane	4.1e-10	9	17.3	52	41	4566
inner membrane	5.7e-10	8	15.3	52	29	4566
cation transport	5.3e-09	12	23.0	52	120	4566
mitochondrial membrane	5.6e-09	9	17.3	52	54	4566
transcription factor activity	1.3e-08	18	34.6	52	340	4566
proton-transporting ATP synthase complex (sensu Eukarya)	3.8e-08	5	9.6	52	10	4566
vacuolar hydrogen-transporting ATPase	3.8e-08	5	9.6	52	10	4566
electron transport	1.2e-07	11	21.1	52	128	4566
oxidoreductase activity	5.0e-07	14	26.9	52	254	4566
transcription regulator activity	5.9e-07	23	44.2	52	703	4566
ion transport	8.1e-07	12	23.0	52	188	4566
electron transporter activity	1.0e-06	14	26.9	52	269	4566
DNA-directed RNA polymerase I activity	2.9e-06	4	7.6	52	10	4566
DNA-directed RNA polymerase II activity	2.9e-06	4	7.6	52	10	4566
DNA-directed RNA polymerase II\, core complex	4.6e-06	4	7.6	52	11	4566
DNA-directed RNA polymerase III activity	4.6e-06	4	7.6	52	11	4566
DNA-directed RNA polymerase activity	6.9e-06	4	7.6	52	12	4566
cation transporter activity	9.4e-06	6	11.5	52	45	4566
DNA-directed RNA polymerase II\, holoenzyme	9.9e-06	4	7.6	52	13	4566
ammonia oxidation	1.3e-05	3	5.7	52	5	4566
ubiquinol-cytochrome c reductase activity	1.3e-05	3	5.7	52	5	4566
hydrogen-exporting ATPase activity\, phosphorylative mechanism	2.7e-05	3	5.7	52	6	4566
regulation of transcription\, DNA-dependent	5.2e-05	18	34.6	52	595	4566
mitochondrial electron transport chain	0.0001	3	5.7	52	9	4566

Visual display

Below is a visual display of the module. Shown are those arrays in which the module's genes significantly change, and the direction of change (induction/repression) in each array is indicated (middle, labeled 'Module changes'; red/green row). The arrays that correspond to the significant clinical attributes are also shown (top; brown rows). The gene sets that compose the module are also shown (left) along with an indication of the membership of the module genes in these gene sets.

You can also view the images within GeneXPress by loading the module gxp file file.

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