Module 315 -- Spindle and kinetochore

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General Properties
Below we list the number of gene sets from which the module was composed was originally composed, and the number of genes and experiments that it contains. Clicking on the number of genes will display a detailed list of all the genes in the module. Clicking on the number of experiments will display a detailed list of all the experiments in the module.
Num gene sets: 3
Num genes: 16 (see 857 additional genes for this module)
Num experiments: 314 (159 induced, 155 repressed)
Parent module: None
Children modules: None


Jump to: Home | General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Gene sets
Below we list the gene sets from which the module was originally composed. Clicking on a gene set will display all the genes associated with that gene set. Also listed are all the other modules in which the gene set participates.
kinetochore
spindle
mitotic checkpoint


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Enriched clinical annotations
For each of the clinical annotations, we tested whether it was enriched in the set of arrays in which the module is significantly induced (or repressed). Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of induced (or repressed) module's arrays in which they appear. We also show the fraction of the module's induced (or repressed) arrays with the given annotation ('Hits (%)' column). For completeness, we also list the total number of relevant induced arrays in the module ('Module hits in category' column), total number of arrays in the compendium in which the corresponding annotation is present ('Arrays in annotation' column), and the total number of relevant arrays in the compendium ('Arrays' column). Note that the 'relevant' arrays may be different for each annotation, since it includes only arrays in which the annotation was relevant (i.e., present or not present) and excludes arrays where the value of the annotation was not known. Rows that correspond to annotations that were enriched in the induced arrays of the module have a red background, while rows corresponding to annotations enriched in the repressed arrays have a green background. For each annotation, we also list the other modules in which it was enriched.
Clinical annotation Category P-value Hits Hits(%) Module hits in category Arrays in annotation Arrays
Hematologic cancer and cell line (Stimulated PBMC) Stimulated PBMC 8.0e-33 29 100 29 30 182
Macrophages (Stimulated PBMC) Stimulated PBMC 8.0e-33 29 100 29 30 182
Chronic lymphocytic leukemia (B lymphoma) B lymphoma 1.4e-19 34 68 50 46 245
Leukemia (B lymphoma) B lymphoma 1.4e-19 34 68 50 46 245
Leukemia or leukemia cell line (B lymphoma) B lymphoma 1.4e-19 34 68 50 46 245
Cell line (B lymphoma) B lymphoma 6.5e-15 14 46.6 30 14 245
Non-tumor liver tissue (Liver cancer) Liver cancer 2.8e-13 30 93.7 32 76 207
Lymphocytes (B lymphoma*) B lymphoma* 1.1e-11 50 32.2 155 244 1945
B cells (B lymphoma*) B lymphoma* 2.0e-11 48 30.9 155 231 1945
Cancer (B lymphoma*) B lymphoma* 2.2e-07 37 23.8 155 200 1945
Hematologic cancer (B lymphoma*) B lymphoma* 2.2e-07 37 23.8 155 200 1945
B. petrussis stimulated immune cells (Stimulated PBMC) Stimulated PBMC 1.2e-06 19 95 20 67 144
Cancer and cell line (B lymphoma*) B lymphoma* 1.3e-06 37 23.8 155 214 1945
Hematologic cancer and cell line (B lymphoma*) B lymphoma* 1.3e-06 37 23.8 155 214 1945
Liver tissue (Liver cancer*) Liver cancer* 1.0e-05 32 20.6 155 187 1945
Cell line (Breast cancer) Breast cancer 1.5e-05 14 53.8 26 30 152
Cancer and cell line (Liver cancer) Liver cancer 2.5e-05 20 100 20 126 207
Gram negative bacteria stimulated immune cells (Stimulated PBMC) Stimulated PBMC 3.0e-05 19 95 20 78 144
B. petrussis A2 stimulated immune cells (Stimulated PBMC) Stimulated PBMC 3.2e-05 5 25 20 5 144
B. petrussis Tox 6 stimulated immune cells (Stimulated PBMC) Stimulated PBMC 3.2e-05 5 25 20 5 144
Liver tissue, cancer or cell line (Liver cancer*) Liver cancer* 3.3e-05 32 20.6 155 197 1945
Bone marrow (Leukemia) Leukemia 3.7e-05 7 77.7 9 23 141
Cancer and cell line (Fibroblast EWS-FLI*) Fibroblast EWS-FLI* 3.7e-05 6 3.8 155 10 1945
Cell line (Fibroblast EWS-FLI*) Fibroblast EWS-FLI* 3.7e-05 6 3.8 155 10 1945
EWS/FLI expressing fibroblasts (Fibroblast EWS-FLI*) Fibroblast EWS-FLI* 3.7e-05 6 3.8 155 10 1945
Fibroblasts (Fibroblast EWS-FLI*) Fibroblast EWS-FLI* 3.7e-05 6 3.8 155 10 1945
Skin fibroblasts (Fibroblast EWS-FLI*) Fibroblast EWS-FLI* 3.7e-05 6 3.8 155 10 1945
Cancer and cell line (Breast cancer*) Breast cancer* 4.4e-05 26 16.3 159 143 1945
Grade 3 (Breast cancer) Breast cancer 5.6e-05 11 100 11 38 85
Liver cancer cell line (Liver cancer) Liver cancer 6.2e-05 6 30 20 10 207
Cell line (Liver cancer) Liver cancer 0.0001 6 30 20 11 207
Hepatitis infected liver (Liver cancer*) Liver cancer* 0.0001 26 16.7 155 156 1945
Centroblasts (Various tumors) Various tumors 0.0001 3 60 5 5 154
GC B like DLBCL (Various tumors) Various tumors 0.0001 3 60 5 5 154
Hematologic samples and cell lines (Stimulated PBMC*) Stimulated PBMC* 0.0001 29 18.2 159 182 1945
Monocytes (Stimulated PBMC*) Stimulated PBMC* 0.0001 29 18.2 159 182 1945
Hematologic samples (B lymphoma) B lymphoma 0.0002 12 24 50 22 245
Normal lung tissue (Lung cancer) Lung cancer 0.0003 5 50 10 22 276
B cells (Leukemia) Leukemia 0.0004 9 100 9 62 141


Jump to: Home | General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Enriched GO annotations
For each GO annotation, we tested whether it was enriched in the set of genes of the module. Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of the module's genes in which they appear. We also show the fraction of the module's genes with the given GO annotation that are included in this module ('Hits (%)' column). For completeness, we also list the total number of genes in the module ('Module genes' column), total number of genes in the compendium in which the corresponding annotation is present ('Genes in annotation' column), and the total number of genes in the compendium ('Genes' column).
GO annotation P-value Hits Hits(%) Module genes Genes in annotation Genes
spindle 2.2e-23 10 62.5 16 15 4566
mitosis 7.2e-17 10 62.5 16 50 4566
kinetochore 2.9e-13 6 37.5 16 11 4566
microtubule cytoskeleton 7.5e-13 11 68.7 16 176 4566
regulation of mitosis 1.0e-12 6 37.5 16 13 4566
cell cycle 2.5e-12 10 62.5 16 135 4566
mitotic checkpoint 1.4e-11 5 31.2 16 8 4566
cytoskeleton 6.3e-11 11 68.7 16 263 4566
M phase of mitotic cell cycle 1.5e-09 5 31.2 16 17 4566
regulation of transcription 2.7e-09 7 43.7 16 76 4566
nuclear division 3.9e-09 5 31.2 16 20 4566
M phase 1.6e-08 5 31.2 16 26 4566
regulation of cell cycle 2.2e-08 8 50 16 163 4566
transcription\, DNA-dependent 2.7e-08 8 50 16 167 4566
transcription 5.8e-08 8 50 16 184 4566
cell cycle checkpoint 7.0e-08 4 25 16 13 4566
mitotic cell cycle 5.6e-07 5 31.2 16 51 4566
microtubule 1.9e-06 3 18.7 16 8 4566
cytoskeleton-dependent intracellular transport 4.9e-06 4 25 16 35 4566
intracellular transport 6.9e-06 4 25 16 38 4566
cytokinesis 1.9e-05 4 25 16 49 4566


Jump to: Home | General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Visual display
Below is a visual display of the module. Shown are those arrays in which the module's genes significantly change, and the direction of change (induction/repression) in each array is indicated (middle, labeled 'Module changes'; red/green row). The arrays that correspond to the significant clinical attributes are also shown (top; brown rows). The gene sets that compose the module are also shown (left) along with an indication of the membership of the module genes in these gene sets.
You can also view the images within GeneXPress by loading the module gxp file file.
 
 





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