Module 267

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General Properties
Below we list the number of gene sets from which the module was composed was originally composed, and the number of genes and experiments that it contains. Clicking on the number of genes will display a detailed list of all the genes in the module. Clicking on the number of experiments will display a detailed list of all the experiments in the module.
Num gene sets: 4
Num genes: 15 (see 1466 additional genes for this module)
Num experiments: 47 (12 induced, 35 repressed)
Parent module: 328
Children modules: 216


Jump to: Home | General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Gene sets
Below we list the gene sets from which the module was originally composed. Clicking on a gene set will display all the genes associated with that gene set. Also listed are all the other modules in which the gene set participates.
nicotinic acetylcholine_activated cation_selective channel activity
nicotinic acetylcholine_gated receptor_channel complex
acetylcholine receptor activity
excitatory extracellular ligand_gated ion channel activity


Jump to: Home | General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Enriched clinical annotations
For each of the clinical annotations, we tested whether it was enriched in the set of arrays in which the module is significantly induced (or repressed). Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of induced (or repressed) module's arrays in which they appear. We also show the fraction of the module's induced (or repressed) arrays with the given annotation ('Hits (%)' column). For completeness, we also list the total number of relevant induced arrays in the module ('Module hits in category' column), total number of arrays in the compendium in which the corresponding annotation is present ('Arrays in annotation' column), and the total number of relevant arrays in the compendium ('Arrays' column). Note that the 'relevant' arrays may be different for each annotation, since it includes only arrays in which the annotation was relevant (i.e., present or not present) and excludes arrays where the value of the annotation was not known. Rows that correspond to annotations that were enriched in the induced arrays of the module have a red background, while rows corresponding to annotations enriched in the repressed arrays have a green background. For each annotation, we also list the other modules in which it was enriched.
Clinical annotation Category P-value Hits Hits(%) Module hits in category Arrays in annotation Arrays
Acute leukemia (Leukemia*) Leukemia* 7.0e-31 30 85.7 35 141 1945
Cancer and cell line (Leukemia*) Leukemia* 7.0e-31 30 85.7 35 141 1945
Cancer (Leukemia*) Leukemia* 7.0e-31 30 85.7 35 141 1945
Hematologic cancer and cell line (Leukemia*) Leukemia* 7.0e-31 30 85.7 35 141 1945
Hematologic cancer (Leukemia*) Leukemia* 7.0e-31 30 85.7 35 141 1945
Hematologic samples and cell lines (Leukemia*) Leukemia* 7.0e-31 30 85.7 35 141 1945
Leukemia (Leukemia*) Leukemia* 7.0e-31 30 85.7 35 141 1945
Leukemia or leukemia cell line (Leukemia*) Leukemia* 7.0e-31 30 85.7 35 141 1945
Monocytes (Leukemia*) Leukemia* 7.0e-31 30 85.7 35 141 1945
B cells (Leukemia) Leukemia 8.0e-12 29 96.6 30 62 141
Bone marrow (Leukemia) Leukemia 3.3e-08 16 53.3 30 23 141
Lymphocytes (Leukemia) Leukemia 6.2e-06 29 96.6 30 91 141
Primary blood mononuclear cells (Leukemia) Leukemia 1.0e-05 13 43.3 30 21 141
Acute lymphocytic leukemia (Leukemia) Leukemia 1.7e-05 29 96.6 30 99 149


Jump to: Home | General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Enriched GO annotations
For each GO annotation, we tested whether it was enriched in the set of genes of the module. Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of the module's genes in which they appear. We also show the fraction of the module's genes with the given GO annotation that are included in this module ('Hits (%)' column). For completeness, we also list the total number of genes in the module ('Module genes' column), total number of genes in the compendium in which the corresponding annotation is present ('Genes in annotation' column), and the total number of genes in the compendium ('Genes' column).
GO annotation P-value Hits Hits(%) Module genes Genes in annotation Genes
excitatory extracellular ligand-gated ion channel activity 6.6e-40 15 100 15 19 4566
extracellular ligand-gated ion channel activity 1.7e-34 15 100 15 33 4566
ligand-gated ion channel activity 1.8e-31 15 100 15 48 4566
ion channel activity 5.4e-25 15 100 15 117 4566
alpha-type channel activity 4.1e-24 15 100 15 133 4566
ion transport 9.5e-22 15 100 15 188 4566
nicotinic acetylcholine-activated cation-selective channel activity 6.2e-20 8 53.3 15 10 4566
channel/pore class transporter activity 1.4e-17 15 100 15 351 4566
synaptic transmission 1.7e-17 12 80 15 116 4566
acetylcholine receptor activity 2.8e-17 7 46.6 15 9 4566
nicotinic acetylcholine-gated receptor-channel complex 2.8e-17 7 46.6 15 9 4566
small molecule transport 2.9e-17 12 80 15 121 4566
vesicle-mediated transport 1.1e-14 12 80 15 196 4566
receptor activity 3.2e-14 15 100 15 582 4566
amine receptor activity 1.5e-12 7 46.6 15 30 4566
integral to plasma membrane 6.9e-12 14 93.3 15 612 4566
signal transduction 4.9e-10 14 93.3 15 831 4566
response to extracellular stimulus 8.7e-10 12 80 15 500 4566
transmembrane receptor activity 6.8e-09 11 73.3 15 448 4566
cell communication 9.7e-09 14 93.3 15 1030 4566
rhodopsin-like receptor activity 1.6e-07 7 46.6 15 147 4566
neurotransmitter receptor activity 3.5e-07 4 26.6 15 20 4566
G-protein coupled receptor activity 4.3e-07 7 46.6 15 170 4566
transmission of nerve impulse 2.3e-06 3 20 15 9 4566
obsolete 2.4e-06 12 80 15 990 4566
GABA-A receptor activity 1.8e-05 3 20 15 17 4566
signal transducer activity 3.8e-05 11 73.3 15 1026 4566
chloride transport 6.3e-05 3 20 15 25 4566
inorganic anion transport 0.0001 3 20 15 31 4566


Jump to: Home | General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Visual display
Below is a visual display of the module. Shown are those arrays in which the module's genes significantly change, and the direction of change (induction/repression) in each array is indicated (middle, labeled 'Module changes'; red/green row). The arrays that correspond to the significant clinical attributes are also shown (top; brown rows). The gene sets that compose the module are also shown (left) along with an indication of the membership of the module genes in these gene sets.
You can also view the images within GeneXPress by loading the module gxp file file.
 
 





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