Module 247 -- Xenobiotic metabolism

General Properties
Below we list the number of gene sets from which the module was composed was originally composed, and the number of genes and experiments that it contains. Clicking on the number of genes will display a detailed list of all the genes in the module. Clicking on the number of experiments will display a detailed list of all the experiments in the module.
Num gene sets:	2
Num genes:	37 (see 1969 additional genes for this module)
Num experiments:	232 (98 induced, 134 repressed)
Parent module:	None
Children modules:	None

Gene sets
Below we list the gene sets from which the module was originally composed. Clicking on a gene set will display all the genes associated with that gene set. Also listed are all the other modules in which the gene set participates.
xenobiotic metabolism
antimicrobial peptide activity

Enriched clinical annotations
For each of the clinical annotations, we tested whether it was enriched in the set of arrays in which the module is significantly induced (or repressed). Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of induced (or repressed) module's arrays in which they appear. We also show the fraction of the module's induced (or repressed) arrays with the given annotation ('Hits (%)' column). For completeness, we also list the total number of relevant induced arrays in the module ('Module hits in category' column), total number of arrays in the compendium in which the corresponding annotation is present ('Arrays in annotation' column), and the total number of relevant arrays in the compendium ('Arrays' column). Note that the 'relevant' arrays may be different for each annotation, since it includes only arrays in which the annotation was relevant (i.e., present or not present) and excludes arrays where the value of the annotation was not known. Rows that correspond to annotations that were enriched in the induced arrays of the module have a red background, while rows corresponding to annotations enriched in the repressed arrays have a green background. For each annotation, we also list the other modules in which it was enriched.
Clinical annotation	Category	P-value	Hits	Hits(%)	Module hits in category	Arrays in annotation	Arrays
Acute leukemia (Leukemia*)	Leukemia*	9.5e-32	55	41.0	134	141	1945
Cancer and cell line (Leukemia*)	Leukemia*	9.5e-32	55	41.0	134	141	1945
Cancer (Leukemia*)	Leukemia*	9.5e-32	55	41.0	134	141	1945
Hematologic cancer and cell line (Leukemia*)	Leukemia*	9.5e-32	55	41.0	134	141	1945
Hematologic cancer (Leukemia*)	Leukemia*	9.5e-32	55	41.0	134	141	1945
Hematologic samples and cell lines (Leukemia*)	Leukemia*	9.5e-32	55	41.0	134	141	1945
Leukemia (Leukemia*)	Leukemia*	9.5e-32	55	41.0	134	141	1945
Leukemia or leukemia cell line (Leukemia*)	Leukemia*	9.5e-32	55	41.0	134	141	1945
Monocytes (Leukemia*)	Leukemia*	9.5e-32	55	41.0	134	141	1945
Liver tissue (Liver cancer*)	Liver cancer*	1.3e-27	50	51.0	98	187	1945
Liver tissue, cancer or cell line (Liver cancer*)	Liver cancer*	2.0e-26	50	51.0	98	197	1945
Hepatitis infected liver (Liver cancer*)	Liver cancer*	1.1e-21	41	41.8	98	156	1945
Cancer and cell line (Liver cancer)	Liver cancer	4.7e-10	38	100	38	126	207
B cells (Leukemia)	Leukemia	4.1e-09	41	74.5	55	62	141
Liver cancer cell line (Liver cancer)	Liver cancer	1.4e-08	10	26.3	38	10	207
Cell line (Liver cancer)	Liver cancer	1.4e-07	10	26.3	38	11	207
Bone marrow (Leukemia)	Leukemia	3.5e-07	20	36.3	55	23	141
Metastasis (Liver cancer)	Liver cancer	8.7e-07	9	23.6	38	10	207
Lymphocytes (Leukemia)	Leukemia	2.0e-05	47	85.4	55	91	141
Non-tumor liver tissue (Liver cancer)	Liver cancer	2.6e-05	31	62	50	76	207
Liver tissue, cancer or cell line (Liver cancer*)	Liver cancer*	3.2e-05	29	21.6	134	197	1945
Acute lymphocytic leukemia (Leukemia)	Leukemia	0.0001	47	85.4	55	99	149
Primary blood mononuclear cells (Leukemia)	Leukemia	0.0002	16	29.0	55	21	141

Enriched GO annotations
For each GO annotation, we tested whether it was enriched in the set of genes of the module. Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of the module's genes in which they appear. We also show the fraction of the module's genes with the given GO annotation that are included in this module ('Hits (%)' column). For completeness, we also list the total number of genes in the module ('Module genes' column), total number of genes in the compendium in which the corresponding annotation is present ('Genes in annotation' column), and the total number of genes in the compendium ('Genes' column).
GO annotation	P-value	Hits	Hits(%)	Module genes	Genes in annotation	Genes
xenobiotic metabolism	1.7e-67	31	83.7	37	37	4566
response to xenobiotic stimulus	1.2e-43	31	83.7	37	133	4566
response to chemical substance	1.8e-31	31	83.7	37	308	4566
antimicrobial peptide activity	9.6e-29	16	43.2	37	27	4566
defense/immunity protein activity	1.1e-17	16	43.2	37	103	4566
response to abiotic stimulus	6.2e-13	31	83.7	37	1228	4566
antifungal peptide activity	2.6e-11	5	13.5	37	5	4566
antibacterial peptide activity	1.4e-09	5	13.5	37	8	4566
alcohol metabolism	5.0e-08	5	13.5	37	14	4566
hydrolase activity\, acting on carbon-nitrogen (but not peptide) bonds	2.8e-05	4	10.8	37	23	4566
aromatic compound metabolism	4.0e-05	4	10.8	37	25	4566
aldehyde dehydrogenase activity	5.6e-05	3	8.1	37	10	4566

Visual display

Below is a visual display of the module. Shown are those arrays in which the module's genes significantly change, and the direction of change (induction/repression) in each array is indicated (middle, labeled 'Module changes'; red/green row). The arrays that correspond to the significant clinical attributes are also shown (top; brown rows). The gene sets that compose the module are also shown (left) along with an indication of the membership of the module genes in these gene sets.

You can also view the images within GeneXPress by loading the module gxp file file.

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