Module 347 -- cGMP signaling in leukemias

General Properties
Below we list the number of gene sets from which the module was composed was originally composed, and the number of genes and experiments that it contains. Clicking on the number of genes will display a detailed list of all the genes in the module. Clicking on the number of experiments will display a detailed list of all the experiments in the module.
Num gene sets:	4
Num genes:	10 (see 902 additional genes for this module)
Num experiments:	33 (12 induced, 21 repressed)
Parent module:	445
Children modules:	65

Gene sets
Below we list the gene sets from which the module was originally composed. Clicking on a gene set will display all the genes associated with that gene set. Also listed are all the other modules in which the gene set participates.
guanylate cyclase activity
cGMP biosynthesis
cyclic nucleotide metabolism
cyclic nucleotide biosynthesis

Enriched clinical annotations
For each of the clinical annotations, we tested whether it was enriched in the set of arrays in which the module is significantly induced (or repressed). Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of induced (or repressed) module's arrays in which they appear. We also show the fraction of the module's induced (or repressed) arrays with the given annotation ('Hits (%)' column). For completeness, we also list the total number of relevant induced arrays in the module ('Module hits in category' column), total number of arrays in the compendium in which the corresponding annotation is present ('Arrays in annotation' column), and the total number of relevant arrays in the compendium ('Arrays' column). Note that the 'relevant' arrays may be different for each annotation, since it includes only arrays in which the annotation was relevant (i.e., present or not present) and excludes arrays where the value of the annotation was not known. Rows that correspond to annotations that were enriched in the induced arrays of the module have a red background, while rows corresponding to annotations enriched in the repressed arrays have a green background. For each annotation, we also list the other modules in which it was enriched.
Clinical annotation	Category	P-value	Hits	Hits(%)	Module hits in category	Arrays in annotation	Arrays
Leukemia (General compendium)	General compendium	1.1e-19	20	95.2	21	198	1946
Leukemia or leukemia cell line (General compendium)	General compendium	4.6e-19	20	95.2	21	212	1946
Acute lymphocytic leukemia (General compendium)	General compendium	5.7e-16	15	71.4	21	99	1946
Monocytes (General compendium)	General compendium	3.0e-15	21	100	21	404	1946
Hematologic cancer (General compendium)	General compendium	4.8e-14	20	95.2	21	372	1946
Hematologic cancer and cell line (General compendium)	General compendium	1.5e-13	21	100	21	486	1946
Hematologic samples and cell lines (General compendium)	General compendium	2.3e-12	21	100	21	551	1946
B cells (General compendium)	General compendium	2.5e-06	13	61.9	21	316	1946
Lymphocytes (General compendium)	General compendium	2.0e-05	15	71.4	21	518	1946
Cancer (General compendium)	General compendium	0.0001	20	95.2	21	1110	1946

Enriched GO annotations
For each GO annotation, we tested whether it was enriched in the set of genes of the module. Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of the module's genes in which they appear. We also show the fraction of the module's genes with the given GO annotation that are included in this module ('Hits (%)' column). For completeness, we also list the total number of genes in the module ('Module genes' column), total number of genes in the compendium in which the corresponding annotation is present ('Genes in annotation' column), and the total number of genes in the compendium ('Genes' column).
GO annotation	P-value	Hits	Hits(%)	Module genes	Genes in annotation	Genes
cyclic nucleotide metabolism	2.4e-28	10	100	10	13	4609
cyclic nucleotide biosynthesis	8.5e-25	9	90	10	12	4609
guanylate cyclase activity	4.0e-22	8	80	10	10	4609
cGMP biosynthesis	1.3e-20	7	70	10	7	4609
nucleotide metabolism	1.2e-19	10	100	10	64	4609
nucleotide biosynthesis	6.3e-19	9	90	10	38	4609
lyase activity	1.6e-13	8	80	10	76	4609
response to red/far-red light	5.3e-09	7	70	10	158	4609
intracellular signaling cascade	2.0e-08	8	80	10	322	4609
response to light	1.6e-07	7	70	10	259	4609
response to radiation	2.0e-07	7	70	10	266	4609
circulation	3.8e-06	4	40	10	56	4609
enzyme linked receptor protein signaling pathway	2.0e-05	3	30	10	27	4609
protein amino acid phosphorylation	6.2e-05	5	50	10	231	4609
protein tyrosine kinase activity	8.4e-05	4	40	10	121	4609

Visual display

Below is a visual display of the module. Shown are those arrays in which the module's genes significantly change, and the direction of change (induction/repression) in each array is indicated (middle, labeled 'Module changes'; red/green row). The arrays that correspond to the significant clinical attributes are also shown (top; brown rows). The gene sets that compose the module are also shown (left) along with an indication of the membership of the module genes in these gene sets.

You can also view the images within GeneXPress by loading the module gxp file file.

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