Module 385 -- Heparin binding

General Properties
Below we list the number of gene sets from which the module was composed was originally composed, and the number of genes and experiments that it contains. Clicking on the number of genes will display a detailed list of all the genes in the module. Clicking on the number of experiments will display a detailed list of all the experiments in the module.
Num gene sets:	2
Num genes:	28 (see 1628 additional genes for this module)
Num experiments:	336 (63 induced, 273 repressed)
Parent module:	None
Children modules:	None

Gene sets
Below we list the gene sets from which the module was originally composed. Clicking on a gene set will display all the genes associated with that gene set. Also listed are all the other modules in which the gene set participates.
heparin binding
glycosaminoglycan binding

Enriched clinical annotations
For each of the clinical annotations, we tested whether it was enriched in the set of arrays in which the module is significantly induced (or repressed). Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of induced (or repressed) module's arrays in which they appear. We also show the fraction of the module's induced (or repressed) arrays with the given annotation ('Hits (%)' column). For completeness, we also list the total number of relevant induced arrays in the module ('Module hits in category' column), total number of arrays in the compendium in which the corresponding annotation is present ('Arrays in annotation' column), and the total number of relevant arrays in the compendium ('Arrays' column). Note that the 'relevant' arrays may be different for each annotation, since it includes only arrays in which the annotation was relevant (i.e., present or not present) and excludes arrays where the value of the annotation was not known. Rows that correspond to annotations that were enriched in the induced arrays of the module have a red background, while rows corresponding to annotations enriched in the repressed arrays have a green background. For each annotation, we also list the other modules in which it was enriched.
Clinical annotation	Category	P-value	Hits	Hits(%)	Module hits in category	Arrays in annotation	Arrays
Lung tissue, cancer or cell line (Lung cancer*)	Lung cancer*	7.8e-67	146	53.6	272	276	1945
Cancer and cell line (Lung cancer*)	Lung cancer*	1.2e-62	136	50	272	252	1945
Cancer (Lung cancer*)	Lung cancer*	1.2e-62	136	50	272	252	1945
Lung cancer (Lung cancer*)	Lung cancer*	5.5e-59	129	47.4	272	238	1945
Lung cancer or cell line (Lung cancer*)	Lung cancer*	5.5e-59	129	47.4	272	238	1945
Non small cell lung cancer and cell line (Lung cancer*)	Lung cancer*	3.3e-48	110	40.4	272	205	1945
Non small cell lung cancer (Lung cancer*)	Lung cancer*	3.3e-48	110	40.4	272	205	1945
Liver tissue (Liver cancer*)	Liver cancer*	5.3e-10	24	38.0	63	187	1945
Hematologic samples and cell lines (Various tumors)	Various tumors	1.4e-09	21	70	30	37	154
Hematologic samples (Various tumors)	Various tumors	1.4e-09	21	70	30	37	154
Liver tissue, cancer or cell line (Liver cancer*)	Liver cancer*	1.6e-09	24	38.0	63	197	1945
Hematologic cancer and cell line (Various tumors)	Various tumors	4.1e-08	18	60	30	31	154
Hematologic cancer (Various tumors)	Various tumors	4.1e-08	18	60	30	31	154
Primary blood mononuclear cells (Various tumors)	Various tumors	4.1e-08	18	60	30	31	154
Hepatitis infected liver (Liver cancer*)	Liver cancer*	7.9e-07	18	28.5	63	156	1945
Lymphocytes (Various tumors)	Various tumors	5.5e-06	15	50	30	28	154
Monocytes (Various tumors)	Various tumors	5.5e-06	15	50	30	28	154
Liver cancer cell line (Liver cancer)	Liver cancer	8.8e-06	6	40	15	10	207
Cell line (Liver cancer)	Liver cancer	1.8e-05	6	40	15	11	207
Breast tissue or cancer (Breast cancer*)	Breast cancer*	6.1e-05	13	20.6	63	118	1945
Female hormonal tissue or cancer (Breast cancer*)	Breast cancer*	6.1e-05	13	20.6	63	118	1945
Colon cancer (Liver cancer)	Liver cancer	8.7e-05	4	26.6	15	5	207
Colon cancer metastasis to liver (Liver cancer)	Liver cancer	8.7e-05	4	26.6	15	5	207
Colon cancer or cell line (Liver cancer)	Liver cancer	8.7e-05	4	26.6	15	5	207
Colon tissue, cancer or cell line (Liver cancer)	Liver cancer	8.7e-05	4	26.6	15	5	207
Female hormonal tissue, cancer or cell line (Breast cancer*)	Breast cancer*	9.8e-05	14	22.2	63	141	1945
Breast tissue, cancer or cell line (Breast cancer*)	Breast cancer*	0.0001	14	22.2	63	142	1945
Metastasis (Liver cancer)	Liver cancer	0.0002	5	33.3	15	10	207
T cells (Various tumors)	Various tumors	0.0002	5	16.6	30	5	154
Stage T1 (Lung cancer)	Lung cancer	0.0003	108	86.4	125	153	195
Cancer and cell line (Liver cancer)	Liver cancer	0.0004	15	100	15	126	207

Enriched GO annotations
For each GO annotation, we tested whether it was enriched in the set of genes of the module. Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of the module's genes in which they appear. We also show the fraction of the module's genes with the given GO annotation that are included in this module ('Hits (%)' column). For completeness, we also list the total number of genes in the module ('Module genes' column), total number of genes in the compendium in which the corresponding annotation is present ('Genes in annotation' column), and the total number of genes in the compendium ('Genes' column).
GO annotation	P-value	Hits	Hits(%)	Module genes	Genes in annotation	Genes
glycosaminoglycan binding	4.7e-62	28	100	28	44	4566
heparin binding	2.6e-56	26	92.8	28	40	4566
binding	4.0e-18	28	100	28	1103	4566
cell communication	4.6e-08	20	71.4	28	1030	4566
extracellular space	2.3e-07	10	35.7	28	212	4566
receptor binding	6.2e-07	10	35.7	28	235	4566
inflammatory response	3.7e-05	6	21.4	28	108	4566
immune response	5.0e-05	11	39.2	28	469	4566
cell adhesion molecule activity	5.1e-05	6	21.4	28	114	4566
chemokine receptor binding	5.2e-05	4	14.2	28	35	4566
chemotaxis	6.7e-05	5	17.8	28	73	4566
energy taxis	7.1e-05	5	17.8	28	74	4566
lipid transporter activity	8.0e-05	4	14.2	28	39	4566
taxis	8.1e-05	5	17.8	28	76	4566
response to extracellular stimulus	9.1e-05	11	39.2	28	500	4566
response to biotic stimulus	9.7e-05	12	42.8	28	600	4566
cell-cell signaling	0.0001	7	25	28	194	4566

Visual display

Below is a visual display of the module. Shown are those arrays in which the module's genes significantly change, and the direction of change (induction/repression) in each array is indicated (middle, labeled 'Module changes'; red/green row). The arrays that correspond to the significant clinical attributes are also shown (top; brown rows). The gene sets that compose the module are also shown (left) along with an indication of the membership of the module genes in these gene sets.

You can also view the images within GeneXPress by loading the module gxp file file.

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