Module 513 -- Collagen and collagen binding proteins

General Properties
Below we list the number of gene sets from which the module was composed was originally composed, and the number of genes and experiments that it contains. Clicking on the number of genes will display a detailed list of all the genes in the module. Clicking on the number of experiments will display a detailed list of all the experiments in the module.
Num gene sets:	2
Num genes:	9 (see 1698 additional genes for this module)
Num experiments:	394 (179 induced, 215 repressed)
Parent module:	None
Children modules:	None

Gene sets
Below we list the gene sets from which the module was originally composed. Clicking on a gene set will display all the genes associated with that gene set. Also listed are all the other modules in which the gene set participates.
fibrillar collagen
collagen binding

Enriched clinical annotations
For each of the clinical annotations, we tested whether it was enriched in the set of arrays in which the module is significantly induced (or repressed). Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of induced (or repressed) module's arrays in which they appear. We also show the fraction of the module's induced (or repressed) arrays with the given annotation ('Hits (%)' column). For completeness, we also list the total number of relevant induced arrays in the module ('Module hits in category' column), total number of arrays in the compendium in which the corresponding annotation is present ('Arrays in annotation' column), and the total number of relevant arrays in the compendium ('Arrays' column). Note that the 'relevant' arrays may be different for each annotation, since it includes only arrays in which the annotation was relevant (i.e., present or not present) and excludes arrays where the value of the annotation was not known. Rows that correspond to annotations that were enriched in the induced arrays of the module have a red background, while rows corresponding to annotations enriched in the repressed arrays have a green background. For each annotation, we also list the other modules in which it was enriched.
Clinical annotation	Category	P-value	Hits	Hits(%)	Module hits in category	Arrays in annotation	Arrays
Diffuse large B cell lymphoma - DLBCL (B lymphoma)	B lymphoma	1.8e-12	40	97.5	41	126	245
Diffuse large B cell lymphoma tumor or cell line (B lymphoma)	B lymphoma	3.2e-11	40	97.5	41	134	245
Lung carcinoid (Lung cancer)	Lung cancer	4.0e-10	16	32	50	20	276
Cancer and cell line (Gliomas*)	Gliomas*	1.2e-07	19	8.8	215	47	1945
Cancer (Gliomas*)	Gliomas*	1.2e-07	19	8.8	215	47	1945
CNS cancer or cell line (Gliomas*)	Gliomas*	1.2e-07	19	8.8	215	47	1945
CNS tissue, cancer or cell line (Gliomas*)	Gliomas*	1.2e-07	19	8.8	215	47	1945
CNS tumor (Gliomas*)	Gliomas*	1.2e-07	19	8.8	215	47	1945
Cell line (NCI60*)	NCI60*	3.6e-07	35	16.2	215	135	1945
Cancer (B lymphoma*)	B lymphoma*	4.5e-07	40	22.3	179	200	1945
Hematologic cancer (B lymphoma*)	B lymphoma*	4.5e-07	40	22.3	179	200	1945
Chronic lymphocytic leukemia (B lymphoma)	B lymphoma	5.4e-07	22	46.8	47	46	245
Leukemia (B lymphoma)	B lymphoma	5.4e-07	22	46.8	47	46	245
Leukemia or leukemia cell line (B lymphoma)	B lymphoma	5.4e-07	22	46.8	47	46	245
Lymphoma or lymphoma cell line (B lymphoma)	B lymphoma	6.3e-07	40	97.5	41	167	245
Cancer and cell line (NCI60*)	NCI60*	6.5e-07	35	16.2	215	138	1945
Cancer and cell line (B lymphoma*)	B lymphoma*	3.0e-06	40	22.3	179	214	1945
Hematologic cancer and cell line (B lymphoma*)	B lymphoma*	3.0e-06	40	22.3	179	214	1945
Breast cancer cell line (Breast cancer)	Breast cancer	3.0e-06	10	47.6	21	17	152
Adenocarcinoma (Breast cancer*)	Breast cancer*	3.7e-06	26	14.5	179	112	1945
Breast cancer (Breast cancer*)	Breast cancer*	3.7e-06	26	14.5	179	112	1945
Cancer (Breast cancer*)	Breast cancer*	3.7e-06	26	14.5	179	112	1945
Female hormonal cancer (Breast cancer*)	Breast cancer*	3.7e-06	26	14.5	179	112	1945
Cell line (Breast cancer)	Breast cancer	4.1e-06	13	61.9	21	30	152
Female hormonal cancer cell line (Breast cancer)	Breast cancer	9.7e-06	9	42.8	21	15	152
Breast tissue or cancer (Breast cancer*)	Breast cancer*	1.0e-05	26	14.5	179	118	1945
Female hormonal tissue or cancer (Breast cancer*)	Breast cancer*	1.0e-05	26	14.5	179	118	1945
Female hormonal cancer or cell line (Breast cancer*)	Breast cancer*	1.4e-05	27	15.0	179	127	1945
Breast cancer or cell line (Breast cancer*)	Breast cancer*	1.6e-05	27	15.0	179	128	1945
GC B like DLBCL (B lymphoma)	B lymphoma	1.7e-05	20	48.7	41	53	245
B cells (B lymphoma*)	B lymphoma*	2.2e-05	40	22.3	179	231	1945
Lymphocytes (B lymphoma*)	B lymphoma*	3.3e-05	47	21.8	215	244	1945
Lymphocytes (B lymphoma*)	B lymphoma*	3.6e-05	41	22.9	179	244	1945
Cancer and cell line (Lung cancer*)	Lung cancer*	7.9e-05	47	21.8	215	252	1945
Cancer (Lung cancer*)	Lung cancer*	7.9e-05	47	21.8	215	252	1945
Lung tissue, cancer or cell line (Lung cancer*)	Lung cancer*	9.9e-05	50	23.2	215	276	1945
Female hormonal tissue, cancer or cell line (Breast cancer*)	Breast cancer*	0.0001	27	15.0	179	141	1945
Breast tissue, cancer or cell line (Breast cancer*)	Breast cancer*	0.0001	27	15.0	179	142	1945
Cancer and cell line (Breast cancer*)	Breast cancer*	0.0001	27	15.0	179	143	1945
Lung cancer (Lung cancer*)	Lung cancer*	0.0001	44	20.4	215	238	1945
Lung cancer or cell line (Lung cancer*)	Lung cancer*	0.0001	44	20.4	215	238	1945
CNS tissue, cancer or cell line (Neuro tumors*)	Neuro tumors*	0.0002	21	9.7	215	85	1945
Memory B cells (B lymphoma)	B lymphoma	0.0002	5	10.6	47	5	245
Normal lymphocytes (B lymphoma)	B lymphoma	0.0003	14	29.7	47	31	245
B cells (B lymphoma*)	B lymphoma*	0.0003	42	19.5	215	231	1945

Enriched GO annotations
For each GO annotation, we tested whether it was enriched in the set of genes of the module. Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of the module's genes in which they appear. We also show the fraction of the module's genes with the given GO annotation that are included in this module ('Hits (%)' column). For completeness, we also list the total number of genes in the module ('Module genes' column), total number of genes in the compendium in which the corresponding annotation is present ('Genes in annotation' column), and the total number of genes in the compendium ('Genes' column).
GO annotation	P-value	Hits	Hits(%)	Module genes	Genes in annotation	Genes
fibrillar collagen	6.6e-18	6	66.6	9	6	4566
collagen	1.1e-14	7	77.7	9	31	4566
extracellular matrix structural constituent	1.1e-09	7	77.7	9	149	4566
collagen binding	5.2e-08	3	33.3	9	5	4566

Visual display

Below is a visual display of the module. Shown are those arrays in which the module's genes significantly change, and the direction of change (induction/repression) in each array is indicated (middle, labeled 'Module changes'; red/green row). The arrays that correspond to the significant clinical attributes are also shown (top; brown rows). The gene sets that compose the module are also shown (left) along with an indication of the membership of the module genes in these gene sets.

You can also view the images within GeneXPress by loading the module gxp file file.

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