Module 543 -- Annexin, MHCII, and lectins

General Properties
Below we list the number of gene sets from which the module was composed was originally composed, and the number of genes and experiments that it contains. Clicking on the number of genes will display a detailed list of all the genes in the module. Clicking on the number of experiments will display a detailed list of all the experiments in the module.
Num gene sets:	5
Num genes:	17 (see 814 additional genes for this module)
Num experiments:	197 (62 induced, 135 repressed)
Parent module:	None
Children modules:	391 390

Gene sets
Below we list the gene sets from which the module was originally composed. Clicking on a gene set will display all the genes associated with that gene set. Also listed are all the other modules in which the gene set participates.
monosaccharide binding
galactose binding
phospholipase inhibitor activity
calcium_dependent phospholipid binding
antigen processing, exogenous antigen via MHC class II

Enriched clinical annotations
For each of the clinical annotations, we tested whether it was enriched in the set of arrays in which the module is significantly induced (or repressed). Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of induced (or repressed) module's arrays in which they appear. We also show the fraction of the module's induced (or repressed) arrays with the given annotation ('Hits (%)' column). For completeness, we also list the total number of relevant induced arrays in the module ('Module hits in category' column), total number of arrays in the compendium in which the corresponding annotation is present ('Arrays in annotation' column), and the total number of relevant arrays in the compendium ('Arrays' column). Note that the 'relevant' arrays may be different for each annotation, since it includes only arrays in which the annotation was relevant (i.e., present or not present) and excludes arrays where the value of the annotation was not known. Rows that correspond to annotations that were enriched in the induced arrays of the module have a red background, while rows corresponding to annotations enriched in the repressed arrays have a green background. For each annotation, we also list the other modules in which it was enriched.
Clinical annotation	Category	P-value	Hits	Hits(%)	Module hits in category	Arrays in annotation	Arrays
Cancer and cell line (Lung cancer*)	Lung cancer*	1.9e-28	68	50.3	135	252	1945
Cancer (Lung cancer*)	Lung cancer*	1.9e-28	68	50.3	135	252	1945
Lung tissue, cancer or cell line (Lung cancer*)	Lung cancer*	9.5e-26	68	50.3	135	276	1945
Lung cancer (Lung cancer*)	Lung cancer*	9.9e-23	60	44.4	135	238	1945
Lung cancer or cell line (Lung cancer*)	Lung cancer*	9.9e-23	60	44.4	135	238	1945
Lung carcinoid (Lung cancer)	Lung cancer	6.1e-14	20	29.4	68	20	276
Normal lung tissue (Lung cancer)	Lung cancer	6.5e-11	10	83.3	12	22	276
Normal tissue (Lung cancer)	Lung cancer	1.1e-10	10	83.3	12	23	276
Malignant glioblastoma (Various tumors)	Various tumors	1.8e-07	5	100	5	9	154
Non small cell lung cancer and cell line (Lung cancer*)	Lung cancer*	3.5e-07	34	25.1	135	205	1945
Non small cell lung cancer (Lung cancer*)	Lung cancer*	3.5e-07	34	25.1	135	205	1945
CNS cancer or cell line (Various tumors)	Various tumors	6.4e-06	5	100	5	16	154
CNS tumor (Various tumors)	Various tumors	6.4e-06	5	100	5	16	154
Hematologic cancer and cell line (NCI60)	NCI60	1.2e-05	7	58.3	12	14	139
Hematologic samples and cell lines (NCI60)	NCI60	1.2e-05	7	58.3	12	14	139
Leukemia cell line (NCI60)	NCI60	1.2e-05	7	58.3	12	14	139
Hematologic cancer and cell line (Stimulated PBMC)	Stimulated PBMC	1.2e-05	6	100	6	30	182
Macrophages (Stimulated PBMC)	Stimulated PBMC	1.2e-05	6	100	6	30	182
CNS tissue, cancer or cell line (Various tumors)	Various tumors	3.0e-05	5	100	5	21	154
Cancer and cell line (Gliomas*)	Gliomas*	0.0002	11	8.1	135	47	1945
Cancer (Gliomas*)	Gliomas*	0.0002	11	8.1	135	47	1945
CNS cancer or cell line (Gliomas*)	Gliomas*	0.0002	11	8.1	135	47	1945
CNS tissue, cancer or cell line (Gliomas*)	Gliomas*	0.0002	11	8.1	135	47	1945
CNS tumor (Gliomas*)	Gliomas*	0.0002	11	8.1	135	47	1945

Enriched GO annotations
For each GO annotation, we tested whether it was enriched in the set of genes of the module. Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of the module's genes in which they appear. We also show the fraction of the module's genes with the given GO annotation that are included in this module ('Hits (%)' column). For completeness, we also list the total number of genes in the module ('Module genes' column), total number of genes in the compendium in which the corresponding annotation is present ('Genes in annotation' column), and the total number of genes in the compendium ('Genes' column).
GO annotation	P-value	Hits	Hits(%)	Module genes	Genes in annotation	Genes
phospholipase inhibitor activity	6.8e-15	6	35.2	17	7	4566
calcium-dependent phospholipid binding	2.0e-13	6	35.2	17	10	4566
antigen processing\, exogenous antigen via MHC class II	2.2e-12	5	29.4	17	6	4566
monosaccharide binding	9.3e-11	5	29.4	17	10	4566
phospholipid binding	1.2e-10	6	35.2	17	24	4566
antigen presentation\, peptide antigen	7.3e-10	5	29.4	17	14	4566
antigen processing	7.3e-10	5	29.4	17	14	4566
anticoagulant activity	4.5e-09	4	23.5	17	7	4566
galactose binding	9.1e-09	4	23.5	17	8	4566
lipid binding	6.5e-08	6	35.2	17	64	4566
heterophilic cell adhesion	3.7e-07	5	29.4	17	44	4566
sugar binding	7.9e-07	5	29.4	17	51	4566
carbohydrate binding	8.7e-07	5	29.4	17	52	4566
enzyme inhibitor activity	1.2e-06	6	35.2	17	105	4566
calcium ion binding	3.1e-06	7	41.1	17	195	4566
lectin	1.5e-05	3	17.6	17	14	4566
binding	6.7e-05	12	70.5	17	1103	4566

Visual display

Below is a visual display of the module. Shown are those arrays in which the module's genes significantly change, and the direction of change (induction/repression) in each array is indicated (middle, labeled 'Module changes'; red/green row). The arrays that correspond to the significant clinical attributes are also shown (top; brown rows). The gene sets that compose the module are also shown (left) along with an indication of the membership of the module genes in these gene sets.

You can also view the images within GeneXPress by loading the module gxp file file.

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