Module 142

General Properties
Below we list the number of gene sets from which the module was composed was originally composed, and the number of genes and experiments that it contains. Clicking on the number of genes will display a detailed list of all the genes in the module. Clicking on the number of experiments will display a detailed list of all the experiments in the module.
Num gene sets:	2
Num genes:	10 (see 746 additional genes for this module)
Num experiments:	87 (11 induced, 76 repressed)
Parent module:	269
Children modules:	None

Gene sets
Below we list the gene sets from which the module was originally composed. Clicking on a gene set will display all the genes associated with that gene set. Also listed are all the other modules in which the gene set participates.
steroid hormone receptor activity
ligand_dependent nuclear receptor activity

Enriched clinical annotations
For each of the clinical annotations, we tested whether it was enriched in the set of arrays in which the module is significantly induced (or repressed). Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of induced (or repressed) module's arrays in which they appear. We also show the fraction of the module's induced (or repressed) arrays with the given annotation ('Hits (%)' column). For completeness, we also list the total number of relevant induced arrays in the module ('Module hits in category' column), total number of arrays in the compendium in which the corresponding annotation is present ('Arrays in annotation' column), and the total number of relevant arrays in the compendium ('Arrays' column). Note that the 'relevant' arrays may be different for each annotation, since it includes only arrays in which the annotation was relevant (i.e., present or not present) and excludes arrays where the value of the annotation was not known. Rows that correspond to annotations that were enriched in the induced arrays of the module have a red background, while rows corresponding to annotations enriched in the repressed arrays have a green background. For each annotation, we also list the other modules in which it was enriched.
Clinical annotation	Category	P-value	Hits	Hits(%)	Module hits in category	Arrays in annotation	Arrays
Non small cell lung cancer (General compendium)	General compendium	1.9e-38	54	71.0	76	205	1946
Lung cancer (General compendium)	General compendium	1.0e-36	56	73.6	76	244	1946
Lung tissue, cancer or cell line (General compendium)	General compendium	2.4e-36	60	78.9	76	304	1946
Non small cell lung cancer and cell line (General compendium)	General compendium	2.8e-36	54	71.0	76	223	1946
Lung cancer or cell line (General compendium)	General compendium	7.4e-35	56	73.6	76	262	1946
Cancer (General compendium)	General compendium	6.3e-13	71	93.4	76	1110	1946
Adenocarcinoma (General compendium)	General compendium	3.3e-08	40	52.6	76	466	1946
Cancer and cell line (General compendium)	General compendium	1.6e-07	73	96.0	76	1429	1946
Squamous cell lung cancer (Lung cancer)	Lung cancer	2.9e-05	18	30	60	35	276

Enriched GO annotations
For each GO annotation, we tested whether it was enriched in the set of genes of the module. Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of the module's genes in which they appear. We also show the fraction of the module's genes with the given GO annotation that are included in this module ('Hits (%)' column). For completeness, we also list the total number of genes in the module ('Module genes' column), total number of genes in the compendium in which the corresponding annotation is present ('Genes in annotation' column), and the total number of genes in the compendium ('Genes' column).
GO annotation	P-value	Hits	Hits(%)	Module genes	Genes in annotation	Genes
steroid hormone receptor activity	4.4e-24	10	100	10	26	4609
ligand-dependent nuclear receptor activity	1.6e-23	10	100	10	29	4609
transcription factor activity	4.8e-12	10	100	10	345	4609
receptor activity	1.0e-09	10	100	10	585	4609
regulation of transcription\, DNA-dependent	1.3e-09	10	100	10	600	4609
chemosensory perception	5.1e-09	10	100	10	688	4609
sensory perception	6.7e-09	10	100	10	706	4609
transcription regulator activity	7.5e-09	10	100	10	714	4609
steroid binding	9.7e-08	4	40	10	23	4609
nucleus	1.7e-07	10	100	10	976	4609
signal transducer activity	3.1e-07	10	100	10	1035	4609
endomembrane system	3.3e-07	10	100	10	1040	4609
vitamin binding	5.0e-07	4	40	10	34	4609
response to abiotic stimulus	1.9e-06	10	100	10	1238	4609
transcription factor binding	2.7e-06	5	50	10	122	4609
transcription cofactor activity	3.1e-06	5	50	10	126	4609
response to extracellular stimulus	1.7e-05	7	70	10	509	4609

Visual display

Below is a visual display of the module. Shown are those arrays in which the module's genes significantly change, and the direction of change (induction/repression) in each array is indicated (middle, labeled 'Module changes'; red/green row). The arrays that correspond to the significant clinical attributes are also shown (top; brown rows). The gene sets that compose the module are also shown (left) along with an indication of the membership of the module genes in these gene sets.

You can also view the images within GeneXPress by loading the module gxp file file.

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