Module 146 -- GPCR

General Properties
Below we list the number of gene sets from which the module was composed was originally composed, and the number of genes and experiments that it contains. Clicking on the number of genes will display a detailed list of all the genes in the module. Clicking on the number of experiments will display a detailed list of all the experiments in the module.
Num gene sets:	2
Num genes:	102 (see 2478 additional genes for this module)
Num experiments:	437 (169 induced, 268 repressed)
Parent module:	None
Children modules:	None

Gene sets
Below we list the gene sets from which the module was originally composed. Clicking on a gene set will display all the genes associated with that gene set. Also listed are all the other modules in which the gene set participates.
rhodopsin_like receptor activity
G_protein coupled receptor activity

Enriched clinical annotations
For each of the clinical annotations, we tested whether it was enriched in the set of arrays in which the module is significantly induced (or repressed). Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of induced (or repressed) module's arrays in which they appear. We also show the fraction of the module's induced (or repressed) arrays with the given annotation ('Hits (%)' column). For completeness, we also list the total number of relevant induced arrays in the module ('Module hits in category' column), total number of arrays in the compendium in which the corresponding annotation is present ('Arrays in annotation' column), and the total number of relevant arrays in the compendium ('Arrays' column). Note that the 'relevant' arrays may be different for each annotation, since it includes only arrays in which the annotation was relevant (i.e., present or not present) and excludes arrays where the value of the annotation was not known. Rows that correspond to annotations that were enriched in the induced arrays of the module have a red background, while rows corresponding to annotations enriched in the repressed arrays have a green background. For each annotation, we also list the other modules in which it was enriched.
Clinical annotation	Category	P-value	Hits	Hits(%)	Module hits in category	Arrays in annotation	Arrays
Liver tissue (Liver cancer*)	Liver cancer*	8.9e-23	60	35.5	169	187	1945
Liver tissue, cancer or cell line (Liver cancer*)	Liver cancer*	2.0e-21	60	35.5	169	197	1945
Hepatitis infected liver (Liver cancer*)	Liver cancer*	7.1e-18	49	28.9	169	156	1945
Non-tumor liver tissue (Liver cancer)	Liver cancer	4.9e-13	45	75	60	76	207
Invasive liver tumor (Liver cancer)	Liver cancer	7.6e-11	26	52	50	38	207
Prostate (Prostate cancer*)	Prostate cancer*	1.2e-10	39	14.5	268	101	1945
Cancer and cell line (Liver cancer)	Liver cancer	1.7e-10	48	96	50	126	207
Hepatocellular carcinoma (Liver cancer)	Liver cancer	2.2e-09	43	86	50	104	207
Hematologic samples and cell lines (B lymphoma)	B lymphoma	2.8e-09	32	94.1	34	121	245
Lymphoma (B lymphoma)	B lymphoma	6.4e-09	26	76.4	34	77	245
Cancer (Liver cancer)	Liver cancer	3.1e-08	44	88	50	115	207
Lymphocytes (Leukemia)	Leukemia	3.2e-08	38	97.4	39	91	141
Acute lymphocytic leukemia (Leukemia)	Leukemia	1.5e-07	38	97.4	39	99	149
Adenocarcinoma (Liver cancer)	Liver cancer	3.1e-07	39	78	50	97	207
Cell line (Breast cancer)	Breast cancer	3.7e-07	15	62.5	24	30	152
Breast cancer cell line (Breast cancer)	Breast cancer	1.0e-06	11	45.8	24	17	152
Hepatitis infected liver (Liver cancer*)	Liver cancer*	1.5e-06	43	16.0	268	156	1945
Female hormonal cancer cell line (Breast cancer)	Breast cancer	2.7e-06	10	41.6	24	15	152
Acute leukemia (Leukemia*)	Leukemia*	4.7e-06	39	14.5	268	141	1945
Cancer and cell line (Leukemia*)	Leukemia*	4.7e-06	39	14.5	268	141	1945
Cancer (Leukemia*)	Leukemia*	4.7e-06	39	14.5	268	141	1945
Hematologic cancer and cell line (Leukemia*)	Leukemia*	4.7e-06	39	14.5	268	141	1945
Hematologic cancer (Leukemia*)	Leukemia*	4.7e-06	39	14.5	268	141	1945
Hematologic samples and cell lines (Leukemia*)	Leukemia*	4.7e-06	39	14.5	268	141	1945
Leukemia (Leukemia*)	Leukemia*	4.7e-06	39	14.5	268	141	1945
Leukemia or leukemia cell line (Leukemia*)	Leukemia*	4.7e-06	39	14.5	268	141	1945
Monocytes (Leukemia*)	Leukemia*	4.7e-06	39	14.5	268	141	1945
B cells (Leukemia)	Leukemia	7.1e-06	29	74.3	39	62	141
Liver tissue, cancer or cell line (Liver cancer*)	Liver cancer*	7.2e-06	49	18.2	268	197	1945
Liver tissue (Liver cancer*)	Liver cancer*	2.0e-05	46	17.1	268	187	1945
Activated B like DLBCL (B lymphoma)	B lymphoma	4.8e-05	7	63.6	11	30	245
Hematologic cancer and cell line (Stimulated PBMC)	Stimulated PBMC	7.1e-05	9	60	15	30	182
Macrophages (Stimulated PBMC)	Stimulated PBMC	7.1e-05	9	60	15	30	182
Bone marrow (Leukemia)	Leukemia	0.0002	14	35.8	39	23	141

Enriched GO annotations
For each GO annotation, we tested whether it was enriched in the set of genes of the module. Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of the module's genes in which they appear. We also show the fraction of the module's genes with the given GO annotation that are included in this module ('Hits (%)' column). For completeness, we also list the total number of genes in the module ('Module genes' column), total number of genes in the compendium in which the corresponding annotation is present ('Genes in annotation' column), and the total number of genes in the compendium ('Genes' column).
GO annotation	P-value	Hits	Hits(%)	Module genes	Genes in annotation	Genes
G-protein coupled receptor activity	4.8e-163	102	100	102	170	4566
rhodopsin-like receptor activity	2.7e-132	89	87.2	102	147	4566
transmembrane receptor activity	1.7e-108	102	100	102	448	4566
receptor activity	1.4e-95	102	100	102	582	4566
G-protein coupled receptor protein signaling pathway	5.3e-79	76	74.5	102	245	4566
signal transducer activity	1.2e-68	102	100	102	1026	4566
conjugation without cellular fusion	1.4e-66	60	58.8	102	152	4566
peptide receptor activity\, G-protein coupled	5.3e-56	40	39.2	102	58	4566
peptide receptor activity	2.5e-55	39	38.2	102	55	4566
integral to plasma membrane	2.6e-50	79	77.4	102	612	4566
sensory perception	2.2e-31	67	65.6	102	700	4566
G-protein signaling\, coupled to cyclic nucleotide second messenger	2.8e-29	26	25.4	102	57	4566
G-protein signaling\, coupled to IP3 second messenger (phospholipase C activating)	2.8e-28	24	23.5	102	48	4566
chemosensory perception	5.0e-25	60	58.8	102	682	4566
amine receptor activity	2.8e-23	18	17.6	102	30	4566
cytosolic calcium ion concentration elevation	7.2e-22	16	15.6	102	24	4566
signal transduction	2.3e-20	60	58.8	102	831	4566
cell communication	8.8e-18	63	61.7	102	1030	4566
G-protein signaling\, coupled to cAMP nucleotide second messenger	2.8e-17	16	15.6	102	39	4566
response to abiotic stimulus	1.3e-16	67	65.6	102	1228	4566
G-protein chemoattractant receptor activity	1.3e-16	11	10.7	102	14	4566
cell surface receptor linked signal transduction	1.5e-15	31	30.3	102	259	4566
glutamate receptor activity	3.6e-15	15	14.7	102	42	4566
cAMP-mediated signaling	2.3e-14	13	12.7	102	31	4566
nucleotide receptor activity	4.3e-12	9	8.8	102	15	4566
chemokine binding	7.3e-12	8	7.8	102	11	4566
taxis	5.6e-11	15	14.7	102	76	4566
response to starvation	1.2e-10	8	7.8	102	14	4566
phosphatidylinositol-4\,5-bisphosphate hydrolysis	2.5e-10	7	6.8	102	10	4566
phospholipase C activation	2.5e-10	7	6.8	102	10	4566
feeding behavior	2.6e-10	8	7.8	102	15	4566
chemotaxis	3.8e-10	14	13.7	102	73	4566
energy taxis	4.7e-10	14	13.7	102	74	4566
secretin-like receptor activity	1.6e-09	7	6.8	102	12	4566
intracellular signaling cascade	3.1e-09	26	25.4	102	319	4566
G-protein signaling\, adenylate cyclase inhibiting pathway	2.1e-08	7	6.8	102	16	4566
phototransduction	2.5e-08	8	7.8	102	24	4566
synaptic transmission	2.6e-08	15	14.7	102	116	4566
serotonin receptor activity	2.9e-08	5	4.9	102	6	4566
activation of MAPK	8.8e-08	6	5.8	102	12	4566
adrenoceptor activity	1.0e-07	5	4.9	102	7	4566
rhodopsin mediated signaling	1.6e-07	6	5.8	102	13	4566
thermoregulation	4.0e-07	13	12.7	102	105	4566
G-protein signaling\, adenylate cyclase activating pathway	4.5e-07	6	5.8	102	15	4566
invasive growth	4.5e-07	6	5.8	102	15	4566
rhodopsin mediated phototransduction	4.5e-07	6	5.8	102	15	4566
inflammatory response	5.6e-07	13	12.7	102	108	4566
response to biotic stimulus	1.0e-06	32	31.3	102	600	4566
vesicle-mediated transport	1.0e-06	17	16.6	102	196	4566
coreceptor activity	1.1e-06	5	4.9	102	10	4566
cellular morphogenesis	2.2e-06	6	5.8	102	19	4566
endosome	2.2e-06	6	5.8	102	19	4566
neuropeptide receptor activity	3.4e-06	4	3.9	102	6	4566
prostaglandin receptor activity	3.4e-06	4	3.9	102	6	4566
MAPKKK cascade (osmolarity sensing)	4.4e-06	6	5.8	102	21	4566
adenylate cyclase activation	5.6e-06	5	4.9	102	13	4566
neuropeptide signaling pathway	5.9e-06	7	6.8	102	33	4566
vision	1.0e-05	11	10.7	102	100	4566
MAPKKK cascade	1.3e-05	6	5.8	102	25	4566
perception of light	1.4e-05	11	10.7	102	103	4566
two-component signal transduction system (phosphorelay)	1.7e-05	6	5.8	102	26	4566
acetylcholine receptor activity	2.7e-05	4	3.9	102	9	4566
circulation	2.7e-05	8	7.8	102	56	4566
negative regulation of adenylate cyclase activity	4.4e-05	4	3.9	102	10	4566
nicotinic acetylcholine-activated cation-selective channel activity	4.4e-05	4	3.9	102	10	4566
perception of mechanical stimulus	4.4e-05	4	3.9	102	10	4566
excitatory extracellular ligand-gated ion channel activity	4.5e-05	5	4.9	102	19	4566
channel/pore class transporter activity	7.1e-05	20	19.6	102	351	4566
cellular defense response	0.0001	7	6.8	102	50	4566
alpha-adrenergic receptor activity	0.0001	3	2.9	102	5	4566
G-protein coupled receptor activity\, unknown ligand	0.0001	3	2.9	102	5	4566

Visual display

Below is a visual display of the module. Shown are those arrays in which the module's genes significantly change, and the direction of change (induction/repression) in each array is indicated (middle, labeled 'Module changes'; red/green row). The arrays that correspond to the significant clinical attributes are also shown (top; brown rows). The gene sets that compose the module are also shown (left) along with an indication of the membership of the module genes in these gene sets.

You can also view the images within GeneXPress by loading the module gxp file file.

Note: Since there are 437 experiments, this image does not display the individual experiment names, but rather condenses each experiment to a single pixel without displaying its name. You can fully view the image for this module within GeneXPress, by loading any of the four files mentioned in the line above

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