Module 164 -- Enzyme inhibitors (esp serine proteases)

General Properties
Below we list the number of gene sets from which the module was composed was originally composed, and the number of genes and experiments that it contains. Clicking on the number of genes will display a detailed list of all the genes in the module. Clicking on the number of experiments will display a detailed list of all the experiments in the module.
Num gene sets:	3
Num genes:	61 (see 1960 additional genes for this module)
Num experiments:	493 (172 induced, 321 repressed)
Parent module:	None
Children modules:	None

Gene sets
Below we list the gene sets from which the module was originally composed. Clicking on a gene set will display all the genes associated with that gene set. Also listed are all the other modules in which the gene set participates.
enzyme inhibitor activity
serine protease inhibitor activity
endopeptidase inhibitor activity

Enriched clinical annotations
For each of the clinical annotations, we tested whether it was enriched in the set of arrays in which the module is significantly induced (or repressed). Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of induced (or repressed) module's arrays in which they appear. We also show the fraction of the module's induced (or repressed) arrays with the given annotation ('Hits (%)' column). For completeness, we also list the total number of relevant induced arrays in the module ('Module hits in category' column), total number of arrays in the compendium in which the corresponding annotation is present ('Arrays in annotation' column), and the total number of relevant arrays in the compendium ('Arrays' column). Note that the 'relevant' arrays may be different for each annotation, since it includes only arrays in which the annotation was relevant (i.e., present or not present) and excludes arrays where the value of the annotation was not known. Rows that correspond to annotations that were enriched in the induced arrays of the module have a red background, while rows corresponding to annotations enriched in the repressed arrays have a green background. For each annotation, we also list the other modules in which it was enriched.
Clinical annotation	Category	P-value	Hits	Hits(%)	Module hits in category	Arrays in annotation	Arrays
Liver tissue (Liver cancer*)	Liver cancer*	4.1e-49	86	50	172	187	1945
Liver tissue, cancer or cell line (Liver cancer*)	Liver cancer*	9.3e-47	86	50	172	197	1945
Cancer and cell line (Lung cancer*)	Lung cancer*	1.2e-44	129	40.3	320	252	1945
Cancer (Lung cancer*)	Lung cancer*	1.2e-44	129	40.3	320	252	1945
Lung tissue, cancer or cell line (Lung cancer*)	Lung cancer*	1.4e-40	131	40.9	320	276	1945
Lung cancer (Lung cancer*)	Lung cancer*	3.3e-39	119	37.1	320	238	1945
Lung cancer or cell line (Lung cancer*)	Lung cancer*	3.3e-39	119	37.1	320	238	1945
Hepatitis infected liver (Liver cancer*)	Liver cancer*	2.3e-33	66	38.3	172	156	1945
Non small cell lung cancer and cell line (Lung cancer*)	Lung cancer*	1.2e-22	89	27.8	320	205	1945
Non small cell lung cancer (Lung cancer*)	Lung cancer*	1.2e-22	89	27.8	320	205	1945
Hematologic samples and cell lines (Various tumors)	Various tumors	1.8e-15	28	75.6	37	37	154
Hematologic samples (Various tumors)	Various tumors	1.8e-15	28	75.6	37	37	154
Cancer and cell line (Liver cancer)	Liver cancer	1.0e-14	58	98.3	59	126	207
Non-tumor liver tissue (Liver cancer)	Liver cancer	6.1e-12	55	63.9	86	76	207
Lymphocytes (Various tumors)	Various tumors	7.1e-12	22	59.4	37	28	154
Monocytes (Various tumors)	Various tumors	7.1e-12	22	59.4	37	28	154
Hematologic cancer and cell line (Various tumors)	Various tumors	1.4e-11	23	62.1	37	31	154
Hematologic cancer (Various tumors)	Various tumors	1.4e-11	23	62.1	37	31	154
Primary blood mononuclear cells (Various tumors)	Various tumors	1.4e-11	23	62.1	37	31	154
B cells (Various tumors)	Various tumors	2.1e-09	18	48.6	37	23	154
Lung carcinoid (Lung cancer)	Lung cancer	1.4e-07	20	15.2	131	20	276
Hematologic cancer and cell line (Stimulated PBMC)	Stimulated PBMC	2.2e-07	8	100	8	30	182
Macrophages (Stimulated PBMC)	Stimulated PBMC	2.2e-07	8	100	8	30	182
Lymphoma (Various tumors)	Various tumors	2.6e-07	15	40.5	37	20	154
Cancer (Liver cancer)	Liver cancer	1.2e-06	48	81.3	59	115	207
Liver cancer cell line (Liver cancer)	Liver cancer	1.9e-06	10	16.9	59	10	207
Metastasis (Liver cancer)	Liver cancer	1.9e-06	10	16.9	59	10	207
Cell line (Liver cancer)	Liver cancer	1.6e-05	10	16.9	59	11	207
Diffuse large B cell lymphoma - DLBCL (Various tumors)	Various tumors	4.4e-05	9	24.3	37	11	154
Diffuse large B cell lymphoma tumor or cell line (Various tumors)	Various tumors	4.4e-05	9	24.3	37	11	154
Normal tissue (Liver cancer)	Liver cancer	5.6e-05	13	15.1	86	14	207
Activated B like DLBCL (B lymphoma)	B lymphoma	0.0001	9	45	20	30	245
Diffuse large B cell lymphoma - DLBCL (B lymphoma)	B lymphoma	0.0001	18	90	20	126	245
Hematologic samples (B lymphoma)	B lymphoma	0.0004	7	36.8	19	22	245

Enriched GO annotations
For each GO annotation, we tested whether it was enriched in the set of genes of the module. Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of the module's genes in which they appear. We also show the fraction of the module's genes with the given GO annotation that are included in this module ('Hits (%)' column). For completeness, we also list the total number of genes in the module ('Module genes' column), total number of genes in the compendium in which the corresponding annotation is present ('Genes in annotation' column), and the total number of genes in the compendium ('Genes' column).
GO annotation	P-value	Hits	Hits(%)	Module genes	Genes in annotation	Genes
enzyme inhibitor activity	3.5e-110	61	100	61	105	4566
enzyme regulator activity	7.7e-77	61	100	61	287	4566
endopeptidase inhibitor activity	9.4e-76	44	72.1	61	65	4566
serine protease inhibitor activity	9.2e-44	27	44.2	61	41	4566
cysteine protease inhibitor activity	1.5e-15	9	14.7	61	12	4566
phospholipase inhibitor activity	3.0e-11	6	9.8	61	7	4566
kinase inhibitor activity	4.0e-11	7	11.4	61	12	4566
serpin	8.6e-11	7	11.4	61	13	4566
calcium-dependent phospholipid binding	8.6e-08	5	8.1	61	10	4566
phospholipid binding	4.9e-07	6	9.8	61	24	4566
plasma glycoprotein	4.9e-07	6	9.8	61	24	4566
plasma protein	6.4e-07	6	9.8	61	25	4566
blood coagulation	3.5e-05	6	9.8	61	48	4566
kinase regulator activity	3.9e-05	7	11.4	61	72	4566
cyclin-dependent protein kinase inhibitor activity	4.4e-05	3	4.9	61	6	4566
hemostasis	4.4e-05	6	9.8	61	50	4566
anticoagulant activity	7.6e-05	3	4.9	61	7	4566

Visual display

Below is a visual display of the module. Shown are those arrays in which the module's genes significantly change, and the direction of change (induction/repression) in each array is indicated (middle, labeled 'Module changes'; red/green row). The arrays that correspond to the significant clinical attributes are also shown (top; brown rows). The gene sets that compose the module are also shown (left) along with an indication of the membership of the module genes in these gene sets.

You can also view the images within GeneXPress by loading the module gxp file file.

Note: Since there are 493 experiments, this image does not display the individual experiment names, but rather condenses each experiment to a single pixel without displaying its name. You can fully view the image for this module within GeneXPress, by loading any of the four files mentioned in the line above

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