Enriched clinical annotations |
For each of the clinical annotations, we tested whether it was enriched in the set of arrays in which the module is significantly induced (or repressed). Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of induced (or repressed) module's arrays in which they appear. We also show the fraction of the module's induced (or repressed) arrays with the given annotation ('Hits (%)' column). For completeness, we also list the total number of relevant induced arrays in the module ('Module hits in category' column), total number of arrays in the compendium in which the corresponding annotation is present ('Arrays in annotation' column), and the total number of relevant arrays in the compendium ('Arrays' column). Note that the 'relevant' arrays may be different for each annotation, since it includes only arrays in which the annotation was relevant (i.e., present or not present) and excludes arrays where the value of the annotation was not known. Rows that correspond to annotations that were enriched in the induced arrays of the module have a red background, while rows corresponding to annotations enriched in the repressed arrays have a green background. For each annotation, we also list the other modules in which it was enriched. |
Clinical annotation |
Category |
P-value |
Hits |
Hits(%) |
Module hits in category |
Arrays in annotation |
Arrays |
Diffuse large B cell lymphoma - DLBCL (B lymphoma) |
B lymphoma |
4.3e-24 |
71 |
97.2 |
73 |
126 |
245 |
Hematologic samples (Stimulated PBMC*) |
Stimulated PBMC* |
1.0e-22 |
87 |
20.1 |
432 |
152 |
1945 |
Lymphocytes (Stimulated PBMC*) |
Stimulated PBMC* |
1.0e-22 |
87 |
20.1 |
432 |
152 |
1945 |
Primary blood mononuclear cells (Stimulated PBMC*) |
Stimulated PBMC* |
1.0e-22 |
87 |
20.1 |
432 |
152 |
1945 |
Diffuse large B cell lymphoma tumor or cell line (B lymphoma) |
B lymphoma |
2.0e-21 |
71 |
97.2 |
73 |
134 |
245 |
Hematologic samples and cell lines (Stimulated PBMC*) |
Stimulated PBMC* |
1.5e-19 |
93 |
21.5 |
432 |
182 |
1945 |
Monocytes (Stimulated PBMC*) |
Stimulated PBMC* |
1.5e-19 |
93 |
21.5 |
432 |
182 |
1945 |
Stimulated immune cells (Stimulated PBMC*) |
Stimulated PBMC* |
2.8e-15 |
73 |
16.8 |
432 |
143 |
1945 |
Chronic lymphocytic leukemia (B lymphoma) |
B lymphoma |
4.3e-14 |
44 |
36.9 |
119 |
46 |
245 |
Leukemia (B lymphoma) |
B lymphoma |
4.3e-14 |
44 |
36.9 |
119 |
46 |
245 |
Leukemia or leukemia cell line (B lymphoma) |
B lymphoma |
4.3e-14 |
44 |
36.9 |
119 |
46 |
245 |
Activated B like DLBCL (B lymphoma) |
B lymphoma |
2.2e-13 |
27 |
36.9 |
73 |
30 |
245 |
Lymphoma or lymphoma cell line (B lymphoma) |
B lymphoma |
1.5e-12 |
71 |
97.2 |
73 |
167 |
245 |
Cancer and cell line (Liver cancer) |
Liver cancer |
1.8e-12 |
58 |
95.0 |
61 |
126 |
207 |
Lung carcinoid (Lung cancer) |
Lung cancer |
1.9e-12 |
20 |
25.3 |
79 |
20 |
276 |
Acute lymphocytic leukemia (Leukemia) |
Leukemia |
2.9e-12 |
65 |
94.2 |
69 |
99 |
149 |
B cells (Leukemia) |
Leukemia |
3.0e-11 |
46 |
75.4 |
61 |
62 |
141 |
Hematologic cancer and cell line (Stimulated PBMC) |
Stimulated PBMC |
4.3e-11 |
24 |
48 |
50 |
30 |
182 |
Macrophages (Stimulated PBMC) |
Stimulated PBMC |
4.3e-11 |
24 |
48 |
50 |
30 |
182 |
Lymphocytes (Leukemia) |
Leukemia |
5.2e-11 |
57 |
93.4 |
61 |
91 |
141 |
Non-tumor liver tissue (Liver cancer) |
Liver cancer |
3.7e-10 |
46 |
66.6 |
69 |
76 |
207 |
Lymphocytes (B lymphoma*) |
B lymphoma* |
1.8e-09 |
118 |
19.3 |
609 |
244 |
1945 |
Cell line (Breast cancer) |
Breast cancer |
6.1e-09 |
20 |
57.1 |
35 |
30 |
152 |
Hematologic samples (B lymphoma) |
B lymphoma |
4.2e-08 |
22 |
18.4 |
119 |
22 |
245 |
Breast cancer cell line (Breast cancer) |
Breast cancer |
4.5e-08 |
14 |
40 |
35 |
17 |
152 |
Normal lymphocytes (B lymphoma) |
B lymphoma |
2.4e-07 |
28 |
23.5 |
119 |
31 |
245 |
B cells (B lymphoma*) |
B lymphoma* |
2.4e-07 |
107 |
17.5 |
609 |
231 |
1945 |
Cell line (NCI60*) |
NCI60* |
5.4e-07 |
69 |
11.3 |
609 |
135 |
1945 |
Female hormonal cancer cell line (Breast cancer) |
Breast cancer |
1.1e-06 |
12 |
34.2 |
35 |
15 |
152 |
Cancer and cell line (NCI60*) |
NCI60* |
1.5e-06 |
69 |
11.3 |
609 |
138 |
1945 |
Liver tissue (Liver cancer*) |
Liver cancer* |
2.3e-06 |
68 |
15.7 |
432 |
187 |
1945 |
Liver cancer cell line (Liver cancer) |
Liver cancer |
2.8e-06 |
10 |
16.3 |
61 |
10 |
207 |
GC B like DLBCL (B lymphoma) |
B lymphoma |
3.3e-06 |
30 |
41.0 |
73 |
53 |
245 |
Bone marrow (Leukemia) |
Leukemia |
3.5e-06 |
20 |
32.7 |
61 |
23 |
141 |
Cancer (B lymphoma*) |
B lymphoma* |
3.8e-06 |
71 |
16.4 |
432 |
200 |
1945 |
Hematologic cancer (B lymphoma*) |
B lymphoma* |
3.8e-06 |
71 |
16.4 |
432 |
200 |
1945 |
B. petrussis stimulated immune cells (Stimulated PBMC) |
Stimulated PBMC |
7.5e-06 |
30 |
76.9 |
39 |
67 |
144 |
Cancer (Liver cancer) |
Liver cancer |
9.4e-06 |
48 |
78.6 |
61 |
115 |
207 |
Normal lung tissue (Lung cancer) |
Lung cancer |
1.6e-05 |
13 |
24.5 |
53 |
22 |
276 |
Liver tissue, cancer or cell line (Liver cancer*) |
Liver cancer* |
1.9e-05 |
68 |
15.7 |
432 |
197 |
1945 |
Cell line (Liver cancer) |
Liver cancer |
2.3e-05 |
10 |
16.3 |
61 |
11 |
207 |
Cell line (B lymphoma) |
B lymphoma |
2.6e-05 |
14 |
11.7 |
119 |
14 |
245 |
Primary blood mononuclear cells (B lymphoma) |
B lymphoma |
2.6e-05 |
14 |
11.7 |
119 |
14 |
245 |
Gram negative bacteria stimulated immune cells (Stimulated PBMC) |
Stimulated PBMC |
2.8e-05 |
32 |
82.0 |
39 |
78 |
144 |
Normal tissue (Lung cancer) |
Lung cancer |
3.1e-05 |
13 |
24.5 |
53 |
23 |
276 |
Cancer and cell line (B lymphoma*) |
B lymphoma* |
5.7e-05 |
71 |
16.4 |
432 |
214 |
1945 |
Hematologic cancer and cell line (B lymphoma*) |
B lymphoma* |
5.7e-05 |
71 |
16.4 |
432 |
214 |
1945 |
Hepatitis infected liver (Liver cancer*) |
Liver cancer* |
6.9e-05 |
55 |
12.7 |
432 |
156 |
1945 |
Fast doubling (20-40) cell lines (NCI60) |
NCI60 |
0.0001 |
58 |
87.8 |
66 |
90 |
122 |
Stimulated B cells (B lymphoma) |
B lymphoma |
0.0001 |
12 |
10.0 |
119 |
12 |
245 |
Cancer and cell line (B lymphoma*) |
B lymphoma* |
0.0001 |
91 |
14.9 |
609 |
214 |
1945 |
Hematologic cancer and cell line (B lymphoma*) |
B lymphoma* |
0.0001 |
91 |
14.9 |
609 |
214 |
1945 |
Normal female hormonal tissue and cells (Various tumors) |
Various tumors |
0.0002 |
5 |
33.3 |
15 |
8 |
154 |
Normal female hormonal tissue (Various tumors) |
Various tumors |
0.0002 |
5 |
33.3 |
15 |
8 |
154 |