Module 397

General Properties
Below we list the number of gene sets from which the module was composed was originally composed, and the number of genes and experiments that it contains. Clicking on the number of genes will display a detailed list of all the genes in the module. Clicking on the number of experiments will display a detailed list of all the experiments in the module.
Num gene sets:	10
Num genes:	121 (see 1225 additional genes for this module)
Num experiments:	482 (219 induced, 263 repressed)
Parent module:	None
Children modules:	337 320

Gene sets
Below we list the gene sets from which the module was originally composed. Clicking on a gene set will display all the genes associated with that gene set. Also listed are all the other modules in which the gene set participates.
nuclear division
M phase
M phase of mitotic cell cycle
mitotic anaphase
Pyrimidine_metabolism
Ross01 2
Nucleotide Metabolism
primary active transporter activity
P_P_bond_hydrolysis_driven transporter activity
Detweiler01 36

Enriched clinical annotations
For each of the clinical annotations, we tested whether it was enriched in the set of arrays in which the module is significantly induced (or repressed). Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of induced (or repressed) module's arrays in which they appear. We also show the fraction of the module's induced (or repressed) arrays with the given annotation ('Hits (%)' column). For completeness, we also list the total number of relevant induced arrays in the module ('Module hits in category' column), total number of arrays in the compendium in which the corresponding annotation is present ('Arrays in annotation' column), and the total number of relevant arrays in the compendium ('Arrays' column). Note that the 'relevant' arrays may be different for each annotation, since it includes only arrays in which the annotation was relevant (i.e., present or not present) and excludes arrays where the value of the annotation was not known. Rows that correspond to annotations that were enriched in the induced arrays of the module have a red background, while rows corresponding to annotations enriched in the repressed arrays have a green background. For each annotation, we also list the other modules in which it was enriched.
Clinical annotation	Category	P-value	Hits	Hits(%)	Module hits in category	Arrays in annotation	Arrays
Liver tissue (Liver cancer*)	Liver cancer*	1.2e-36	92	34.9	263	187	1945
Liver tissue, cancer or cell line (Liver cancer*)	Liver cancer*	3.0e-34	92	34.9	263	197	1945
Hepatitis infected liver (Liver cancer*)	Liver cancer*	1.2e-26	73	27.7	263	156	1945
Hematologic cancer and cell line (Stimulated PBMC)	Stimulated PBMC	3.9e-26	25	100	25	30	182
Macrophages (Stimulated PBMC)	Stimulated PBMC	3.9e-26	25	100	25	30	182
Non-tumor liver tissue (Liver cancer)	Liver cancer	6.7e-25	68	73.9	92	76	207
Cancer and cell line (Liver cancer)	Liver cancer	1.8e-17	66	98.5	67	126	207
Liver tissue, cancer or cell line (Liver cancer*)	Liver cancer*	7.7e-16	61	27.9	218	197	1945
Hepatitis infected liver (Liver cancer*)	Liver cancer*	1.1e-11	47	21.5	218	156	1945
Liver tissue (Liver cancer*)	Liver cancer*	8.3e-11	51	23.3	218	187	1945
Normal lung tissue (Lung cancer)	Lung cancer	4.7e-09	16	32	50	22	276
Normal tissue (Lung cancer)	Lung cancer	1.3e-08	16	32	50	23	276
Cancer (Liver cancer)	Liver cancer	5.0e-08	55	82.0	67	115	207
Cell line (Liver cancer)	Liver cancer	2.2e-06	11	16.4	67	11	207
Invasive liver tumor (Liver cancer)	Liver cancer	2.7e-06	25	37.3	67	38	207
Adenocarcinoma (Liver cancer)	Liver cancer	2.9e-06	47	70.1	67	97	207
Hepatocellular carcinoma (Liver cancer)	Liver cancer	3.9e-06	49	73.1	67	104	207
Normal tissue (Liver cancer)	Liver cancer	6.4e-06	14	15.2	92	14	207
Cancer and cell line (Breast cancer*)	Breast cancer*	6.7e-06	34	15.5	218	143	1945
Liver cancer cell line (Liver cancer)	Liver cancer	7.7e-06	10	14.9	67	10	207
B. petrussis A2 stimulated immune cells (Stimulated PBMC)	Stimulated PBMC	1.2e-05	5	29.4	17	5	144
B. petrussis Tox 6 stimulated immune cells (Stimulated PBMC)	Stimulated PBMC	1.2e-05	5	29.4	17	5	144
B. petrussis stimulated immune cells (Stimulated PBMC)	Stimulated PBMC	1.7e-05	16	94.1	17	67	144
Stimulated B cells (B lymphoma)	B lymphoma	2.7e-05	7	28	25	12	245
Hematologic samples (B lymphoma)	B lymphoma	5.8e-05	9	36	25	22	245
Cell line (B lymphoma)	B lymphoma	6.3e-05	6	37.5	16	14	245
Small cell lung cancer (Lung cancer)	Lung cancer	8.1e-05	6	22.2	27	10	276
Breast cancer or cell line (Breast cancer*)	Breast cancer*	9.1e-05	29	13.3	218	128	1945
Cell line (Breast cancer)	Breast cancer	0.0001	15	44.1	34	30	152
Normal lymphocytes (B lymphoma)	B lymphoma	0.0002	10	40	25	31	245
Gram negative bacteria stimulated immune cells (Stimulated PBMC)	Stimulated PBMC	0.0002	16	94.1	17	78	144

Enriched GO annotations
For each GO annotation, we tested whether it was enriched in the set of genes of the module. Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of the module's genes in which they appear. We also show the fraction of the module's genes with the given GO annotation that are included in this module ('Hits (%)' column). For completeness, we also list the total number of genes in the module ('Module genes' column), total number of genes in the compendium in which the corresponding annotation is present ('Genes in annotation' column), and the total number of genes in the compendium ('Genes' column).
GO annotation	P-value	Hits	Hits(%)	Module genes	Genes in annotation	Genes
M phase of mitotic cell cycle	2.1e-12	8	16.3	49	17	4566
M phase	2.3e-12	9	18.3	49	26	4566
nuclear division	1.1e-11	8	16.3	49	20	4566
mitosis	5.7e-11	10	20.4	49	50	4566
mitotic cell cycle	7.0e-11	10	20.4	49	51	4566
cell cycle	7.8e-10	13	26.5	49	135	4566
mitotic anaphase	5.0e-08	5	10.2	49	11	4566
regulation of cell cycle	6.2e-06	10	20.4	49	163	4566
viral host cell process manipulation	9.9e-06	8	16.3	49	102	4566
DNA replication and chromosome cycle	1.1e-05	5	10.2	49	29	4566
regulation of transcription	1.3e-05	7	14.2	49	76	4566
spindle	1.4e-05	4	8.1	49	15	4566
transcription\, DNA-dependent	5.4e-05	9	18.3	49	167	4566
transcription	0.0001	9	18.3	49	184	4566

Visual display

Below is a visual display of the module. Shown are those arrays in which the module's genes significantly change, and the direction of change (induction/repression) in each array is indicated (middle, labeled 'Module changes'; red/green row). The arrays that correspond to the significant clinical attributes are also shown (top; brown rows). The gene sets that compose the module are also shown (left) along with an indication of the membership of the module genes in these gene sets.

You can also view the images within GeneXPress by loading the module gxp file file.

Note: Since there are 482 experiments, this image does not display the individual experiment names, but rather condenses each experiment to a single pixel without displaying its name. You can fully view the image for this module within GeneXPress, by loading any of the four files mentioned in the line above

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