Module 64 -- Membranal receptors

General Properties
Below we list the number of gene sets from which the module was composed was originally composed, and the number of genes and experiments that it contains. Clicking on the number of genes will display a detailed list of all the genes in the module. Clicking on the number of experiments will display a detailed list of all the experiments in the module.
Num gene sets:	4
Num genes:	518 (see 2437 additional genes for this module)
Num experiments:	1301 (428 induced, 873 repressed)
Parent module:	None
Children modules:	27

Gene sets
Below we list the gene sets from which the module was originally composed. Clicking on a gene set will display all the genes associated with that gene set. Also listed are all the other modules in which the gene set participates.
integral to plasma membrane
signal transducer activity
transmembrane receptor activity
receptor activity

Enriched clinical annotations
For each of the clinical annotations, we tested whether it was enriched in the set of arrays in which the module is significantly induced (or repressed). Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of induced (or repressed) module's arrays in which they appear. We also show the fraction of the module's induced (or repressed) arrays with the given annotation ('Hits (%)' column). For completeness, we also list the total number of relevant induced arrays in the module ('Module hits in category' column), total number of arrays in the compendium in which the corresponding annotation is present ('Arrays in annotation' column), and the total number of relevant arrays in the compendium ('Arrays' column). Note that the 'relevant' arrays may be different for each annotation, since it includes only arrays in which the annotation was relevant (i.e., present or not present) and excludes arrays where the value of the annotation was not known. Rows that correspond to annotations that were enriched in the induced arrays of the module have a red background, while rows corresponding to annotations enriched in the repressed arrays have a green background. For each annotation, we also list the other modules in which it was enriched.
Clinical annotation	Category	P-value	Hits	Hits(%)	Module hits in category	Arrays in annotation	Arrays
Acute leukemia (Leukemia*)	Leukemia*	1.6e-28	124	14.2	872	141	1945
Cancer and cell line (Leukemia*)	Leukemia*	1.6e-28	124	14.2	872	141	1945
Cancer (Leukemia*)	Leukemia*	1.6e-28	124	14.2	872	141	1945
Hematologic cancer and cell line (Leukemia*)	Leukemia*	1.6e-28	124	14.2	872	141	1945
Hematologic cancer (Leukemia*)	Leukemia*	1.6e-28	124	14.2	872	141	1945
Hematologic samples and cell lines (Leukemia*)	Leukemia*	1.6e-28	124	14.2	872	141	1945
Leukemia (Leukemia*)	Leukemia*	1.6e-28	124	14.2	872	141	1945
Leukemia or leukemia cell line (Leukemia*)	Leukemia*	1.6e-28	124	14.2	872	141	1945
Monocytes (Leukemia*)	Leukemia*	1.6e-28	124	14.2	872	141	1945
Non-tumor liver tissue (Liver cancer)	Liver cancer	3.6e-27	72	72	100	76	207
Cancer and cell line (Liver cancer)	Liver cancer	1.4e-26	91	97.8	93	126	207
Liver tissue (Liver cancer*)	Liver cancer*	9.3e-23	99	23.1	428	187	1945
Liver tissue, cancer or cell line (Liver cancer*)	Liver cancer*	1.6e-20	99	23.1	428	197	1945
Cancer (Liver cancer)	Liver cancer	2.4e-16	80	86.0	93	115	207
Hepatitis infected liver (Liver cancer*)	Liver cancer*	1.0e-14	76	17.7	428	156	1945
Hematologic cancer and cell line (Stimulated PBMC)	Stimulated PBMC	8.0e-14	24	58.5	41	30	182
Macrophages (Stimulated PBMC)	Stimulated PBMC	8.0e-14	24	58.5	41	30	182
Hematologic samples (Stimulated PBMC*)	Stimulated PBMC*	3.9e-13	72	16.8	428	152	1945
Lymphocytes (Stimulated PBMC*)	Stimulated PBMC*	3.9e-13	72	16.8	428	152	1945
Primary blood mononuclear cells (Stimulated PBMC*)	Stimulated PBMC*	3.9e-13	72	16.8	428	152	1945
Hepatocellular carcinoma (Liver cancer)	Liver cancer	6.1e-12	71	76.3	93	104	207
Adenocarcinoma (Liver cancer)	Liver cancer	2.3e-10	66	70.9	93	97	207
Hematologic samples and cell lines (Stimulated PBMC*)	Stimulated PBMC*	1.7e-09	74	17.2	428	182	1945
Monocytes (Stimulated PBMC*)	Stimulated PBMC*	1.7e-09	74	17.2	428	182	1945
Stimulated immune cells (Stimulated PBMC*)	Stimulated PBMC*	6.7e-09	61	14.2	428	143	1945
Cancer and cell line (Various tumors*)	Various tumors*	4.3e-08	74	8.4	872	105	1945
Cancer (Various tumors*)	Various tumors*	4.3e-08	74	8.4	872	105	1945
Activated B like DLBCL (B lymphoma)	B lymphoma	2.6e-07	16	41.0	39	30	245
Diffuse large B cell lymphoma - DLBCL (B lymphoma)	B lymphoma	4.3e-07	34	87.1	39	126	245
Breast tissue or cancer (Breast cancer*)	Breast cancer*	6.7e-07	49	11.4	428	118	1945
Female hormonal tissue or cancer (Breast cancer*)	Breast cancer*	6.7e-07	49	11.4	428	118	1945
Lung cancer (Lung cancer*)	Lung cancer*	6.7e-07	142	16.2	872	238	1945
Lung cancer or cell line (Lung cancer*)	Lung cancer*	6.7e-07	142	16.2	872	238	1945
Cancer and cell line (Lung cancer*)	Lung cancer*	7.4e-07	149	17.0	872	252	1945
Cancer (Lung cancer*)	Lung cancer*	7.4e-07	149	17.0	872	252	1945
Acute lymphocytic leukemia (Leukemia)	Leukemia	1.1e-06	97	73.4	132	99	149
Lymphocytes (Leukemia)	Leukemia	2.7e-06	89	71.7	124	91	141
Invasive liver tumor (Liver cancer)	Liver cancer	2.7e-06	30	32.2	93	38	207
Diffuse large B cell lymphoma tumor or cell line (B lymphoma)	B lymphoma	3.5e-06	34	87.1	39	134	245
Squamous cell lung cancer (Lung cancer)	Lung cancer	5.1e-06	31	20.6	150	35	276
Adenocarcinoma (Breast cancer*)	Breast cancer*	5.9e-06	45	10.5	428	112	1945
Breast cancer (Breast cancer*)	Breast cancer*	5.9e-06	45	10.5	428	112	1945
Cancer (Breast cancer*)	Breast cancer*	5.9e-06	45	10.5	428	112	1945
Female hormonal cancer (Breast cancer*)	Breast cancer*	5.9e-06	45	10.5	428	112	1945
Hematologic samples and cell lines (B lymphoma)	B lymphoma	1.4e-05	78	62.9	124	121	245
Non small cell lung cancer and cell line (Lung cancer*)	Lung cancer*	2.1e-05	120	13.7	872	205	1945
Non small cell lung cancer (Lung cancer*)	Lung cancer*	2.1e-05	120	13.7	872	205	1945
Breast cancer cell line (Breast cancer)	Breast cancer	2.2e-05	14	26.9	52	17	152
Normal tissue (Liver cancer)	Liver cancer	2.2e-05	14	14	100	14	207
Hematologic cancer and cell line (Stimulated immune*)	Stimulated immune*	3.4e-05	25	5.8	428	53	1945
Hematologic samples and cell lines (Stimulated immune*)	Stimulated immune*	3.4e-05	25	5.8	428	53	1945
Macrophages (Stimulated immune*)	Stimulated immune*	3.4e-05	25	5.8	428	53	1945
Monocytes (Stimulated immune*)	Stimulated immune*	3.4e-05	25	5.8	428	53	1945
B. petrussis stimulated immune cells (Stimulated PBMC)	Stimulated PBMC	4.7e-05	22	81.4	27	67	144
Cell line (Breast cancer)	Breast cancer	5.1e-05	20	38.4	52	30	152
Lymphoma (B lymphoma)	B lymphoma	8.6e-05	53	42.7	124	77	245
Cell line (Liver cancer)	Liver cancer	0.0001	11	11.8	93	11	207
B. petrussis A2 stimulated immune cells (Stimulated PBMC)	Stimulated PBMC	0.0001	5	18.5	27	5	144
Female hormonal cancer cell line (Breast cancer)	Breast cancer	0.0001	12	23.0	52	15	152
Female hormonal tissue, cancer or cell line (Breast cancer*)	Breast cancer*	0.0002	49	11.4	428	141	1945
Gram negative bacteria stimulated immune cells (Stimulated PBMC)	Stimulated PBMC	0.0002	23	85.1	27	78	144
Female hormonal cancer or cell line (Breast cancer*)	Breast cancer*	0.0002	45	10.5	428	127	1945
Liver cancer cell line (Liver cancer)	Liver cancer	0.0002	10	10.7	93	10	207
Breast tissue, cancer or cell line (Breast cancer*)	Breast cancer*	0.0002	49	11.4	428	142	1945
Breast cancer or cell line (Breast cancer*)	Breast cancer*	0.0002	45	10.5	428	128	1945
Chronic lymphocytic leukemia (B lymphoma)	B lymphoma	0.0003	34	27.4	124	46	245
Leukemia (B lymphoma)	B lymphoma	0.0003	34	27.4	124	46	245
Leukemia or leukemia cell line (B lymphoma)	B lymphoma	0.0003	34	27.4	124	46	245
Lung tissue, cancer or cell line (Lung cancer*)	Lung cancer*	0.0003	150	17.2	872	276	1945
B cells (Leukemia)	Leukemia	0.0003	61	49.1	124	62	141

Enriched GO annotations
For each GO annotation, we tested whether it was enriched in the set of genes of the module. Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of the module's genes in which they appear. We also show the fraction of the module's genes with the given GO annotation that are included in this module ('Hits (%)' column). For completeness, we also list the total number of genes in the module ('Module genes' column), total number of genes in the compendium in which the corresponding annotation is present ('Genes in annotation' column), and the total number of genes in the compendium ('Genes' column).
GO annotation	P-value	Hits	Hits(%)	Module genes	Genes in annotation	Genes
integral to plasma membrane	1.9e-166	311	60.0	518	612	4566
signal transducer activity	4.2e-154	378	72.9	518	1026	4566
receptor activity	2.4e-124	269	51.9	518	582	4566
transmembrane receptor activity	6.4e-113	228	44.0	518	448	4566
cell communication	2.7e-55	269	51.9	518	1030	4566
response to biotic stimulus	1.5e-53	196	37.8	518	600	4566
signal transduction	1.7e-52	234	45.1	518	831	4566
channel/pore class transporter activity	1.8e-47	139	26.8	518	351	4566
immune response	4.1e-45	160	30.8	518	469	4566
response to stress	4.9e-41	210	40.5	518	792	4566
receptor binding	1.1e-36	100	19.3	518	235	4566
porin activity	3.4e-34	97	18.7	518	235	4566
cell surface receptor linked signal transduction	4.2e-33	101	19.4	518	259	4566
G-protein coupled receptor activity	5.2e-33	80	15.4	518	170	4566
rhodopsin-like receptor activity	3.4e-30	71	13.7	518	147	4566
cell-cell signaling	1.1e-29	82	15.8	518	194	4566
secretion	1.3e-23	84	16.2	518	240	4566
G-protein coupled receptor protein signaling pathway	1.3e-23	85	16.4	518	245	4566
chemotaxis	4.9e-23	43	8.3	518	73	4566
energy taxis	1.0e-22	43	8.3	518	74	4566
taxis	4.6e-22	43	8.3	518	76	4566
chemokine receptor binding	5.5e-21	28	5.4	518	35	4566
transmembrane receptor protein tyrosine kinase activity	3.1e-20	37	7.1	518	62	4566
response to extracellular stimulus	3.9e-20	125	24.1	518	500	4566
conjugation without cellular fusion	3.2e-19	59	11.3	518	152	4566
inflammatory response	1.1e-18	48	9.2	518	108	4566
transmembrane receptor protein kinase activity	2.4e-18	37	7.1	518	68	4566
peptide receptor activity\, G-protein coupled	2.5e-18	34	6.5	518	58	4566
peptide receptor activity	2.9e-18	33	6.3	518	55	4566
protein kinase activity	3.0e-18	46	8.8	518	102	4566
thermoregulation	1.2e-17	46	8.8	518	105	4566
defense response	5.6e-15	76	14.6	518	272	4566
hematopoietin/interferon-class (D200-domain) cytokine receptor activity	5.4e-14	25	4.8	518	42	4566
cytosolic calcium ion concentration elevation	5.1e-13	18	3.4	518	24	4566
alpha-type channel activity	5.3e-13	46	8.8	518	133	4566
ion channel activity	1.3e-12	42	8.1	518	117	4566
G-protein signaling\, coupled to cyclic nucleotide second messenger	8.3e-12	27	5.2	518	57	4566
response to pest/pathogen/parasite	9.0e-12	50	9.6	518	163	4566
growth factor activity	9.6e-12	36	6.9	518	95	4566
interleukin receptor activity	3.2e-11	18	3.4	518	28	4566
T-cell activation	3.8e-11	57	11.0	518	207	4566
lymphocyte activation	5.9e-11	57	11.0	518	209	4566
cytokine activity	6.0e-11	27	5.2	518	61	4566
cellular defense response	8.8e-11	24	4.6	518	50	4566
transmembrane receptor protein tyrosine kinase signaling pathway	2.4e-10	24	4.6	518	52	4566
interleukin binding	4.6e-10	16	3.0	518	25	4566
ion transport	8.1e-10	51	9.8	518	188	4566
extracellular ligand-gated ion channel activity	1.4e-09	18	3.4	518	33	4566
G-protein signaling\, coupled to IP3 second messenger (phospholipase C activating)	1.6e-09	22	4.2	518	48	4566
amine receptor activity	1.9e-09	17	3.2	518	30	4566
eye photoreceptor cell fate commitment	3.5e-09	19	3.6	518	38	4566
protein tyrosine kinase activity	4.5e-09	37	7.1	518	120	4566
calcium ion homeostasis	4.7e-09	12	2.3	518	16	4566
synaptic transmission	6.0e-09	36	6.9	518	116	4566
immunoglobulin receptor activity	6.0e-09	15	2.8	518	25	4566
excitatory extracellular ligand-gated ion channel activity	6.3e-09	13	2.5	518	19	4566
ligand-gated ion channel activity	1.1e-08	21	4.0	518	48	4566
compound eye morphogenesis (sensu Drosophila)	1.7e-08	19	3.6	518	41	4566
post-embryonic morphogenesis	1.7e-08	19	3.6	518	41	4566
post-embryonic development	2.9e-08	19	3.6	518	42	4566
positive regulation of cell proliferation	3.2e-08	25	4.8	518	68	4566
humoral immune response	3.6e-08	35	6.7	518	118	4566
regulation of T-cell proliferation	4.4e-08	25	4.8	518	69	4566
lymphocyte proliferation	6.2e-08	25	4.8	518	70	4566
small molecule transport	7.3e-08	35	6.7	518	121	4566
humoral defense mechanism (sensu Invertebrata)	1.1e-07	25	4.8	518	72	4566
cell adhesion	1.2e-07	52	10.0	518	222	4566
scavenger receptor activity	2.1e-07	8	1.5	518	9	4566
G-protein chemoattractant receptor activity	2.1e-07	10	1.9	518	14	4566
defense/immunity protein activity	5.5e-07	30	5.7	518	103	4566
coreceptor activity	9.5e-07	8	1.5	518	10	4566
Fc receptor activity	9.5e-07	8	1.5	518	10	4566
nicotinic acetylcholine-activated cation-selective channel activity	9.5e-07	8	1.5	518	10	4566
phospholipase C activation	9.5e-07	8	1.5	518	10	4566
proton-dependent oligopeptide transporter activity	1.2e-06	14	2.7	518	30	4566
transmembrane receptor protein phosphatase activity	1.3e-06	9	1.7	518	13	4566
vesicle-mediated transport	1.7e-06	45	8.6	518	196	4566
peptide transporter activity	2.0e-06	14	2.7	518	31	4566
symporter activity	2.0e-06	14	2.7	518	31	4566
chemokine binding	3.1e-06	8	1.5	518	11	4566
acetylcholine receptor activity	6.8e-06	7	1.3	518	9	4566
nicotinic acetylcholine-gated receptor-channel complex	6.8e-06	7	1.3	518	9	4566
neurotransmitter transport	8.5e-06	8	1.5	518	12	4566
porter activity	1.6e-05	16	3.0	518	45	4566
integrin complex	2.0e-05	10	1.9	518	20	4566
cell adhesion receptor activity	2.2e-05	11	2.1	518	24	4566
glutamate receptor activity	2.8e-05	15	2.8	518	42	4566
cell ion homeostasis	2.9e-05	13	2.5	518	33	4566
G-protein signaling\, coupled to cAMP nucleotide second messenger	4.9e-05	14	2.7	518	39	4566
metal ion homeostasis	5.0e-05	12	2.3	518	30	4566
ephrin receptor activity	5.0e-05	7	1.3	518	11	4566
response to viruses	5.4e-05	9	1.7	518	18	4566
voltage-gated potassium channel complex	5.4e-05	9	1.7	518	18	4566
two-component signal transduction system (phosphorelay)	5.6e-05	11	2.1	518	26	4566
hormone activity	7.3e-05	16	3.0	518	50	4566
cation homeostasis	7.3e-05	12	2.3	518	31	4566
integrin-mediated signaling pathway	9.3e-05	10	1.9	518	23	4566
cellular morphogenesis	9.4e-05	9	1.7	518	19	4566
serotonin receptor activity	0.0001	5	0.9	518	6	4566
tumor necrosis factor receptor binding	0.0001	7	1.3	518	12	4566
potassium ion transport	0.0001	14	2.7	518	42	4566
GPI-anchored membrane-bound receptor	0.0001	6	1.1	518	9	4566
integrin binding	0.0001	6	1.1	518	9	4566

Visual display

Below is a visual display of the module. Shown are those arrays in which the module's genes significantly change, and the direction of change (induction/repression) in each array is indicated (middle, labeled 'Module changes'; red/green row). The arrays that correspond to the significant clinical attributes are also shown (top; brown rows). The gene sets that compose the module are also shown (left) along with an indication of the membership of the module genes in these gene sets.

You can also view the images within GeneXPress by loading the module gxp file file.

Note: Since there are 518 genes, this image does not display the individual gene names, but rather condenses each gene to a single pixel without displaying its name. You can fully view the image for this module within GeneXPress, by loading any of the four files mentioned in the line above.

Note: Since there are 1301 experiments, this image does not display the individual experiment names, but rather condenses each experiment to a single pixel without displaying its name. You can fully view the image for this module within GeneXPress, by loading any of the four files mentioned in the line above

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