Home
Figures
Modules
GeneXPress
Global Analysis (Fig. 3)
Experimental Tests
Candidate Regulators
Technical Reports
Links
People
Supplemental Information
|
Regulators Analysis
To analyze the regulators associated with each of the modules, we examined the set of genes in
all the modules regulated by each regulator and evaluated that set using the following sources:
- Functional gene annotations (Gene Ontology, MIPS and KEGG)
- Motif binding sites (known motifs from TRANSFAC
and de-novo motifs learned using a method previously published by Segal, Barash, Simon, Friedman and Koller in
RECOMB 2002)
- Protein-DNA binding assays published in Lee et al, Science...
Each square in the regulator-annotation matrix corresponds to the fraction
of genes in all modules regulated by the regulator that have that annotation. p-values
were computed (correcting for multiple hypotheses) and significant events were colored
in shades of orange and insignificant events in shades of blue (using a significance level of 0.05).
We show the full matrices as well as matrices filtered for only the significant events
as well as matrices where only informative annotations were kept.
|
|