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 >4x |
Module 246 |
| General Properties | |
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| Below we list the number of gene sets from which the module was composed was originally composed, and the number of genes and experiments that it contains. Clicking on the number of genes will display a detailed list of all the genes in the module. Clicking on the number of experiments will display a detailed list of all the experiments in the module. | |
| Num gene sets: | 2 |
| Num genes: | 17 (see 1 additional genes for this module) |
| Num experiments: | 47 (26 induced, 21 repressed) |
| Gene sets | |
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| Below we list the gene sets from which the module was originally composed. Clicking on a gene set will display all the genes associated with that gene set. Also listed are all the other modules in which the gene set participates. | |
| hydrolase activity, acting on glycosyl bonds | 246 370 531 |
| hydrolase activity, acting on carbon_nitrogen (but not peptide) bonds | |
| Enriched clinical annotations | ||||
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| For each of the clinical annotations, we tested whether it was enriched in the set of experiments in which the module is significantly induced (or repressed). Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of induced (or repressed) experiments in which they appear. We also show the fraction of experiments with the given annotation that are included in this module ('Hits (%)' column). Rows that correspond to annotations that were enriched in the induced experiments of the module have a red background, while rows corresponding to annotations enriched in the repressed experiments have a green background. For each annotation, we also list the other modules in which it was enriched. | ||||
| Clinical annotation | P-value | Hits | Hits(%) | Modules |
| Liver cell line | 1.98e-06 | 4 | 19.047 | 1 3 9 10 17 18 19 23 24 27 32 38 40 43 44 45 46 48 49 52 54 57 58 60 63 64 72 73 75 76 78 79 93 95 96 98 99 101 106 107 108 109 112 117 118 119 121 123 124 125 126 128 129 130 131 132 135 139 158 163 164 165 167 169 170 171 172 176 177 180 184 185 198 199 205 208 209 212 213 221 223 235 238 244 246 247 249 252 258 259 263 265 283 286 292 294 295 301 302 305 309 310 320 327 337 342 343 345 349 353 373 388 395 397 401 403 410 415 416 418 424 426 430 436 438 440 443 451 454 456 457 458 461 462 467 477 478 479 496 505 529 536 556 572 |
| Metastasis (liver, lung) | 0.00028 | 3 | 14.285 | 10 40 43 58 78 93 105 106 107 109 117 130 131 132 135 139 140 164 172 184 185 186 194 205 209 212 220 221 227 234 235 239 246 247 249 265 276 286 294 295 305 306 310 327 343 349 354 370 373 397 401 415 422 432 434 440 452 458 464 479 493 495 496 505 506 510 526 529 530 536 |
| Enriched GO annotations | ||||
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| For each GO annotation, we tested whether it was enriched in the set of genes of the module. Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of genes in which they appear. We also show the fraction of genes with the given GO annotation that are included in this module ('Hits (%)' column). | ||||
| GO annotation | P-value | Hits | Hits(%) | |
| hydrolase activity\, acting on glycosyl bonds | 5.09e-29 | 14 | 82.352 | |
| carbohydrate metabolism | 5.39e-20 | 13 | 76.470 | |
| hydrolase activity | 5.52e-17 | 17 | 100 | |
| regulation of metabolism | 1.10e-16 | 15 | 88.235 | |
| lysosome | 2.95e-15 | 9 | 52.941 | |
| catalytic activity | 5.67e-11 | 17 | 100 | |
| sulfur metabolism | 5.98e-05 | 5 | 29.411 | |
| sphingolipid metabolism | 7.17e-05 | 3 | 17.647 | |
| hydrolase activity\, acting on carbon-nitrogen (but not peptide) bonds | 8.98e-05 | 3 | 17.647 | |
| Visual display | |||||||||
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| Below is a visual display of the module. Shown are those arrays in which the module's genes significantly change, and the direction of change (induction/repression) in each array is indicated (middle, labeled 'Module changes'; red/green row). The arrays that correspond to the significant clinical attributes are also shown (top; brown rows). The gene sets that compose the module are also shown (left) along with an indication of the membership of the module genes in these gene sets. | |||||||||
| You can also view the images within GeneXPress by loading the module gxp file file. | |||||||||
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