Module 531

Jump to: General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display

General Properties
Below we list the number of gene sets from which the module was composed was originally composed, and the number of genes and experiments that it contains. Clicking on the number of genes will display a detailed list of all the genes in the module. Clicking on the number of experiments will display a detailed list of all the experiments in the module.
Num gene sets:	5
Num genes:	39 (see additional genes for this module)
Num experiments:	99 (47 induced, 52 repressed)

Jump to: General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display

Gene sets
Below we list the gene sets from which the module was originally composed. Clicking on a gene set will display all the genes associated with that gene set. Also listed are all the other modules in which the gene set participates.
Boldrick02 3	531
peroxidase activity	370 531
hydrolase activity, acting on glycosyl bonds	246 370 531
hydrolase activity, acting on carbon_nitrogen (but not peptide) bonds
Ross00 30	531

Jump to: General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display

Enriched clinical annotations
For each of the clinical annotations, we tested whether it was enriched in the set of experiments in which the module is significantly induced (or repressed). Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of induced (or repressed) experiments in which they appear. We also show the fraction of experiments with the given annotation that are included in this module ('Hits (%)' column). Rows that correspond to annotations that were enriched in the induced experiments of the module have a red background, while rows corresponding to annotations enriched in the repressed experiments have a green background. For each annotation, we also list the other modules in which it was enriched.
Clinical annotation	P-value	Hits	Hits(%)	Modules
PBMC	1.45e-15	29	55.769	37 46 64 69 75 79 84 92 97 108 119 121 128 136 161 169 170 171 174 179 182 208 210 216 223 254 255 261 263 280 292 300 303 308 312 317 345 358 369 375 376 378 399 433 436 439 456 459 481 488 521 522 525 531 532 537 541 544 554 562
Lymphocytes	1.93e-14	40	76.923	37 57 61 65 69 70 76 79 97 119 120 126 128 136 138 145 161 169 170 171 173 174 175 179 182 188 201 204 208 210 214 216 219 237 238 241 247 250 254 255 261 267 280 289 291 292 300 301 303 308 312 313 315 316 317 328 329 330 340 341 345 347 358 361 375 378 387 399 407 433 436 439 451 456 459 466 488 512 522 525 531 532 537 554 562
Blood and blood cells	6.98e-14	27	51.923	37 46 61 64 69 75 76 79 84 92 97 108 119 121 126 128 136 143 161 169 170 171 174 179 182 208 210 223 241 254 255 261 263 280 291 292 300 303 312 317 345 358 375 378 399 433 436 439 449 456 459 481 488 521 522 525 531 532 537 541 544 554 562
Lymphocytes	5.42e-13	36	76.595	37 57 61 65 69 70 76 79 97 119 120 126 128 136 138 145 161 169 170 171 173 174 175 179 182 188 201 204 208 210 214 216 219 237 238 241 247 250 254 255 261 267 280 289 291 292 300 301 303 308 312 313 315 316 317 328 329 330 340 341 345 347 358 361 375 378 387 399 407 433 436 439 451 456 459 466 488 512 522 525 531 532 537 554 562
Stimulate immune cells	8.85e-13	22	42.307	5 15 31 37 46 61 64 69 75 76 79 84 92 97 108 119 121 123 124 126 128 136 161 169 170 171 174 179 182 208 223 237 254 255 261 263 280 289 292 300 301 303 308 312 317 345 358 369 375 376 378 399 433 436 439 456 459 481 488 521 522 525 531 532 537 538 541 544 554 562
Blood and blood cells	3.12e-12	24	51.063	37 46 61 64 69 75 76 79 84 92 97 108 119 121 126 128 136 143 161 169 170 171 174 179 182 208 210 223 241 254 255 261 263 280 291 292 300 303 312 317 345 358 375 378 399 433 436 439 449 456 459 481 488 521 522 525 531 532 537 541 544 554 562
PBMC	5.82e-11	23	48.936	37 46 64 69 75 79 84 92 97 108 119 121 128 136 161 169 170 171 174 179 182 208 210 216 223 254 255 261 263 280 292 300 303 308 312 317 345 358 369 375 376 378 399 433 436 439 456 459 481 488 521 522 525 531 532 537 541 544 554 562
Killed bacteria	1.52e-10	18	34.615	37 46 61 64 69 75 76 79 84 92 108 119 121 126 128 136 161 169 170 171 174 175 179 208 223 237 254 255 263 289 292 300 303 308 312 315 317 345 375 378 399 433 436 439 451 456 459 481 488 521 522 531 532 537 544 562
Stimulate immune cells	7.95e-09	17	36.170	5 15 31 37 46 61 64 69 75 76 79 84 92 97 108 119 121 123 124 126 128 136 161 169 170 171 174 179 182 208 223 237 254 255 261 263 280 289 292 300 301 303 308 312 317 345 358 369 375 376 378 399 433 436 439 456 459 481 488 521 522 525 531 532 537 538 541 544 554 562
Gram positive	1.94e-08	10	19.230	37 69 79 84 92 121 128 136 170 171 179 208 223 255 263 292 317 345 375 378 399 433 436 459 481 488 531 532 544
S. aureus	1.94e-08	10	19.230	37 69 79 84 92 121 128 136 170 171 179 208 223 255 263 292 317 345 375 378 399 433 436 459 481 488 531 532 544
100X stim dose	5.21e-08	8	15.384	37 54 69 136 171 179 208 210 211 255 292 317 345 378 436 459 488 531 532 562
Monocytes	4.06e-07	27	51.923	4 15 27 31 37 61 63 65 69 73 79 82 85 86 87 92 98 99 108 114 117 119 120 121 123 124 126 128 136 138 151 169 171 173 174 175 177 179 182 197 199 208 216 223 237 243 247 248 250 254 255 259 263 264 265 267 273 280 289 292 300 303 308 312 316 317 328 340 341 345 347 358 369 375 376 378 399 403 407 411 414 433 436 439 451 456 459 466 481 488 491 500 518 522 525 531 532 537 538 539 544 562 568
24hr Immune stimul	1.49e-06	5	10.638	37 69 136 179 208 255 292 317 345 378 436 459 531 532
0_5hr Immune stimul	1.54e-06	8	15.384	37 69 136 179 255 292 317 378 459 488 522 531 532
E coli	2.68e-06	5	10.638	37 69 121 136 169 171 179 208 223 254 255 292 300 317 345 378 399 436 439 456 459 488 521 522 531 532
LPS	5.76e-06	6	12.765	37 69 84 119 136 171 179 208 211 255 280 292 303 317 345 378 436 459 481 531 532 544 562
Blood and blood cells and cell lines	5.97e-06	30	57.692	4 15 17 21 27 31 33 37 46 56 57 61 63 64 65 69 70 73 75 76 79 82 85 86 87 94 97 98 99 102 114 117 119 120 124 126 128 136 138 145 151 161 169 170 171 173 174 175 177 178 179 182 188 198 199 201 208 214 216 219 233 238 241 244 247 248 250 252 254 255 259 261 265 267 273 278 280 289 291 292 300 301 303 308 312 315 316 317 328 329 330 332 340 341 345 347 358 361 375 376 378 387 399 403 407 411 433 436 439 449 451 456 459 466 481 488 490 500 512 518 522 525 531 532 537 538 539 541 544 562
Monocytes	1.12e-05	23	48.936	4 15 27 31 37 61 63 65 69 73 79 82 85 86 87 92 98 99 108 114 117 119 120 121 123 124 126 128 136 138 151 169 171 173 174 175 177 179 182 197 199 208 216 223 237 243 247 248 250 254 255 259 263 264 265 267 273 280 289 292 300 303 308 312 316 317 328 340 341 345 347 358 369 375 376 378 399 403 407 411 414 433 436 439 451 456 459 466 481 488 491 500 518 522 525 531 532 537 538 539 544 562 568
1X stim dose	1.20e-05	5	9.615	37 53 54 57 61 69 118 119 126 136 161 171 179 208 255 280 292 303 317 345 378 436 459 531 532
6hr Immune stimul	3.17e-05	6	11.538	37 69 92 119 121 136 171 179 208 223 254 255 292 312 317 345 378 433 436 456 459 488 522 531 532 537 562
Killed bacteria	5.20e-05	11	23.404	37 46 61 64 69 75 76 79 84 92 108 119 121 126 128 136 161 169 170 171 174 175 179 208 223 237 254 255 263 289 292 300 303 308 312 315 317 345 375 378 399 433 436 439 451 456 459 481 488 521 522 531 532 537 544 562
CLL	7.72e-05	7	14.893	3 5 8 16 17 18 21 37 52 53 54 56 57 61 64 69 72 76 79 84 97 98 102 105 118 119 124 125 126 128 136 145 156 158 161 169 170 171 179 182 187 188 197 198 210 212 219 236 237 238 240 244 245 252 254 255 258 261 292 300 301 302 303 308 312 313 315 317 337 344 345 348 358 361 378 399 403 436 451 456 459 485 502 513 522 525 531 532 537 547 554 562 573
1000X stim dose	8.31e-05	4	7.692	37 69 92 126 136 171 179 208 255 292 303 317 345 378 433 436 459 488 531 532
High Ig mut CLL	8.31e-05	4	7.692	16 18 37 53 54 57 61 69 79 98 102 105 119 124 126 128 136 145 161 169 170 179 188 198 210 212 219 238 252 254 255 261 292 301 308 312 315 317 344 361 378 451 456 459 485 502 531 532 537 554
CLL	0.00015	7	13.461	3 5 8 16 17 18 21 37 52 53 54 56 57 61 64 69 72 76 79 84 97 98 102 105 118 119 124 125 126 128 136 145 156 158 161 169 170 171 179 182 187 188 197 198 210 212 219 236 237 238 240 244 245 252 254 255 258 261 292 300 301 302 303 308 312 313 315 317 337 344 345 348 358 361 378 399 403 436 451 456 459 485 502 513 522 525 531 532 537 547 554 562 573
LPS	0.00016	5	9.615	37 69 84 119 136 171 179 208 211 255 280 292 303 317 345 378 436 459 481 531 532 544 562

Jump to: General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display

Enriched GO annotations

For each GO annotation, we tested whether it was enriched in the set of genes of the module. Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of genes in which they appear. We also show the fraction of genes with the given GO annotation that are included in this module ('Hits (%)' column).

Jump to: General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display

Visual display
Below is a visual display of the module. Shown are those arrays in which the module's genes significantly change, and the direction of change (induction/repression) in each array is indicated (middle, labeled 'Module changes'; red/green row). The arrays that correspond to the significant clinical attributes are also shown (top; brown rows). The gene sets that compose the module are also shown (left) along with an indication of the membership of the module genes in these gene sets.
You can also view the images within GeneXPress by loading the module gxp file file.
>4x