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 >4x |
Module 460 |
| General Properties | |
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| Below we list the number of gene sets from which the module was composed was originally composed, and the number of genes and experiments that it contains. Clicking on the number of genes will display a detailed list of all the genes in the module. Clicking on the number of experiments will display a detailed list of all the experiments in the module. | |
| Num gene sets: | 2 |
| Num genes: | 33 (see 17 additional genes for this module) |
| Num experiments: | 44 (10 induced, 34 repressed) |
| Gene sets | |
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| Below we list the gene sets from which the module was originally composed. Clicking on a gene set will display all the genes associated with that gene set. Also listed are all the other modules in which the gene set participates. | |
| Perou99 46 | 460 |
| Ross00 26 | 460 |
| Enriched clinical annotations | ||||
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| For each of the clinical annotations, we tested whether it was enriched in the set of experiments in which the module is significantly induced (or repressed). Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of induced (or repressed) experiments in which they appear. We also show the fraction of experiments with the given annotation that are included in this module ('Hits (%)' column). Rows that correspond to annotations that were enriched in the induced experiments of the module have a red background, while rows corresponding to annotations enriched in the repressed experiments have a green background. For each annotation, we also list the other modules in which it was enriched. | ||||
| Clinical annotation | P-value | Hits | Hits(%) | Modules |
| Chemo cytoxan | 3.49e-16 | 15 | 44.117 | 1 2 3 5 6 8 11 12 15 17 18 19 28 32 38 44 47 50 52 60 62 66 72 83 88 91 100 105 111 114 118 137 151 152 155 157 159 190 257 307 321 323 443 446 460 468 474 494 497 515 570 |
| Chemo cisplatin | 9.01e-16 | 15 | 44.117 | 1 2 3 5 6 8 11 12 17 18 19 20 28 32 38 44 47 50 52 60 62 66 72 83 88 91 100 105 111 114 118 137 151 152 155 157 159 177 190 257 307 321 323 443 446 460 468 474 494 497 515 570 |
| Chemo vincristine | 3.84e-15 | 15 | 44.117 | 1 2 3 5 6 8 11 12 17 18 19 20 24 28 32 38 44 47 50 52 60 62 66 72 83 88 91 100 105 111 114 118 137 151 152 155 157 159 177 190 257 307 321 323 443 446 447 460 468 474 494 497 515 570 |
| Medulloblastoma | 2.34e-14 | 15 | 44.117 | 1 2 3 5 6 8 11 12 15 17 18 19 20 24 28 29 32 38 44 47 50 52 55 60 62 66 72 83 88 91 100 103 105 111 114 118 137 151 152 155 157 159 174 177 190 257 299 307 321 323 443 446 447 460 468 474 494 497 515 570 |
| CNS tumor | 1.15e-12 | 18 | 52.941 | 1 2 3 5 6 8 11 12 13 15 16 17 18 19 20 24 28 29 32 33 38 39 44 47 50 52 53 55 60 62 66 72 83 88 91 100 103 105 111 114 118 137 151 152 155 157 159 174 177 183 190 241 257 274 291 299 307 321 322 323 350 381 388 395 425 443 446 447 460 468 473 474 477 483 494 497 513 515 533 563 570 |
| CNS cancer or cell line | 4.30e-12 | 18 | 52.941 | 1 2 3 5 6 8 11 12 13 15 16 17 18 19 24 28 29 32 33 38 44 47 50 52 53 55 60 62 66 72 83 84 88 91 100 103 105 111 114 118 137 151 152 155 157 159 174 177 183 190 241 257 274 291 299 307 321 322 323 350 381 395 425 443 446 447 460 468 473 474 477 483 497 515 533 563 570 |
| CNS | 1.16e-11 | 18 | 52.941 | 1 2 3 5 6 8 11 12 13 15 16 17 18 19 20 24 28 29 32 33 38 44 47 50 52 53 55 60 62 66 72 83 84 88 91 100 103 105 111 113 114 118 137 151 152 155 157 159 174 177 183 190 241 257 274 291 299 307 321 322 323 350 381 395 425 443 446 447 460 468 473 474 477 483 494 497 515 533 563 570 |
| Stage M1- brain | 1.67e-11 | 11 | 32.352 | 1 2 3 5 6 8 11 12 17 18 19 28 32 38 47 52 60 66 72 83 91 100 105 111 114 118 137 151 152 155 157 159 190 321 323 443 446 447 460 474 497 515 570 |
| Classic Medulloblastoma | 6.69e-11 | 11 | 32.352 | 1 2 3 5 6 8 11 12 15 17 18 19 24 32 38 44 47 52 60 66 72 83 88 100 105 111 114 118 137 151 152 155 157 159 190 321 323 443 446 447 460 468 474 494 497 515 570 |
| Stage T3 - CNS | 1.76e-10 | 9 | 26.470 | 1 2 3 5 8 11 12 15 17 18 19 28 32 38 47 50 52 66 72 83 91 100 105 111 114 118 137 151 152 155 157 159 190 321 323 443 446 460 474 497 515 570 |
| Alive - Brain tumor | 6.68e-10 | 11 | 32.352 | 1 2 3 5 6 8 11 12 15 17 18 19 24 28 32 38 44 47 50 52 60 66 72 88 91 100 105 114 118 137 151 152 155 159 174 190 241 257 274 299 321 443 446 460 474 477 483 497 515 533 563 570 |
| Stage M1 | 8.19e-10 | 11 | 32.352 | 1 2 3 5 6 8 11 12 17 18 19 28 32 38 47 52 66 72 83 100 105 114 118 137 151 152 155 157 159 190 321 323 443 446 460 474 497 515 570 |
| Stage T3 | 4.19e-06 | 9 | 26.470 | 26 159 206 207 258 285 321 389 443 460 497 559 567 |
| Alive - all | 2.32e-05 | 12 | 35.294 | 26 70 169 201 206 207 214 261 321 329 387 389 460 497 512 513 515 525 562 567 |
| Leukemia cell line | 3.40e-05 | 3 | 30 | 1 2 3 5 6 12 15 18 19 33 38 47 52 66 88 100 118 122 128 137 139 170 178 180 190 321 342 357 362 390 419 430 460 474 484 493 543 549 |
| Despoplastic Medulloblastoma | 6.76e-05 | 4 | 11.764 | 3 8 12 18 28 50 72 91 100 152 321 443 460 497 515 |
| Enriched GO annotations | ||||
|---|---|---|---|---|
| For each GO annotation, we tested whether it was enriched in the set of genes of the module. Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of genes in which they appear. We also show the fraction of genes with the given GO annotation that are included in this module ('Hits (%)' column). | ||||
| GO annotation | P-value | Hits | Hits(%) | |
| RNA ligase activity | 9.64e-05 | 3 | 9.090 | |
| Visual display | |||||||||
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| Below is a visual display of the module. Shown are those arrays in which the module's genes significantly change, and the direction of change (induction/repression) in each array is indicated (middle, labeled 'Module changes'; red/green row). The arrays that correspond to the significant clinical attributes are also shown (top; brown rows). The gene sets that compose the module are also shown (left) along with an indication of the membership of the module genes in these gene sets. | |||||||||
| You can also view the images within GeneXPress by loading the module gxp file file. | |||||||||
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