Module 468

Jump to: General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
General Properties
Below we list the number of gene sets from which the module was composed was originally composed, and the number of genes and experiments that it contains. Clicking on the number of genes will display a detailed list of all the genes in the module. Clicking on the number of experiments will display a detailed list of all the experiments in the module.
Num gene sets: 4
Num genes: 22 (see 17 additional genes for this module)
Num experiments: 161 (18 induced, 143 repressed)


Jump to: General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Gene sets
Below we list the gene sets from which the module was originally composed. Clicking on a gene set will display all the genes associated with that gene set. Also listed are all the other modules in which the gene set participates.
Boldrick02 13 468
cell motility 468
Ross01 23 468
Sorlie01 42 468


Jump to: General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Enriched clinical annotations
For each of the clinical annotations, we tested whether it was enriched in the set of experiments in which the module is significantly induced (or repressed). Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of induced (or repressed) experiments in which they appear. We also show the fraction of experiments with the given annotation that are included in this module ('Hits (%)' column). Rows that correspond to annotations that were enriched in the induced experiments of the module have a red background, while rows corresponding to annotations enriched in the repressed experiments have a green background. For each annotation, we also list the other modules in which it was enriched.
Clinical annotation P-value Hits Hits(%) Modules
Cancer tissue 1.25e-19 129 90.209 1 2 3 5 6 7 8 10 11 12 13 19 23 24 27 29 33 36 38 40 41 44 45 46 47 52 55 58 60 63 64 65 66 68 70 72 75 76 78 84 88 89 90 92 93 94 99 100 104 105 107 109 111 112 113 117 118 120 122 127 129 130 131 137 138 140 142 148 153 154 157 164 165 167 168 172 173 174 175 176 181 189 190 194 201 203 204 206 207 209 211 213 214 216 220 222 230 234 235 241 242 247 248 249 250 267 274 290 291 295 297 298 316 324 326 327 329 330 340 341 342 347 357 372 373 374 379 381 382 384 385 387 391 401 404 407 411 416 421 422 426 428 431 435 438 440 446 461 462 464 466 468 469 474 479 483 486 487 497 500 506 512 513 514 515 520 525 533 540 543 549 552 564 570 573
Cancer tissue and cell line 1.77e-12 136 95.104 1 2 5 6 10 11 12 19 23 24 27 33 36 38 41 44 45 46 47 54 55 58 60 63 64 66 75 76 78 84 85 88 89 90 92 94 99 100 105 107 109 112 113 117 120 121 122 125 127 129 130 131 135 137 138 139 140 142 148 153 154 158 164 165 168 171 172 173 174 175 176 178 180 184 189 190 194 199 201 203 204 205 206 208 209 213 214 216 220 222 230 234 235 241 247 249 250 259 274 287 290 291 292 294 295 297 309 316 321 324 326 327 329 330 342 343 345 357 372 373 374 382 385 387 390 391 397 401 404 407 410 416 418 421 422 426 431 435 440 461 462 464 466 467 468 473 474 479 497 505 506 512 513 514 536 540 543 549 552 572 573
Lymphoma tissue 5.05e-12 29 20.279 6 11 19 27 33 47 66 70 88 94 100 105 112 113 117 120 137 138 152 155 174 175 176 201 213 214 220 233 241 244 245 250 278 289 291 322 329 330 387 466 468 512 548
AT/RT (CNS and not) 4.42e-10 9 6.293 3 4 8 13 17 28 32 50 62 81 82 83 86 87 91 102 103 105 111 112 113 114 115 149 151 152 155 157 159 176 233 245 250 274 278 299 316 321 386 425 446 447 468 473 483 497 565 570
Adenocarcinoma (lung) 3.66e-09 35 24.475 1 2 6 7 8 11 12 19 23 24 33 36 38 41 52 54 55 60 66 68 72 76 84 88 89 90 92 93 94 100 104 107 108 109 112 113 118 121 122 129 130 137 139 142 148 153 154 164 165 167 168 172 176 180 181 194 203 204 209 213 220 222 230 234 235 242 263 275 290 297 298 310 322 324 326 342 357 372 373 374 379 382 384 385 401 404 421 426 431 435 438 461 462 464 465 468 471 486 487 514 520 533 540 542 543 549 551 552 564 573
Stage T1 all - lung 9.88e-09 32 22.377 1 2 5 6 7 8 10 11 12 17 19 23 24 33 36 38 40 41 44 45 46 52 54 55 58 60 66 68 72 75 76 84 88 89 90 92 93 94 100 104 107 108 109 112 113 118 121 122 129 130 131 137 139 142 148 153 154 164 165 167 168 172 176 180 181 190 194 203 204 209 213 220 222 223 230 234 235 242 262 263 266 290 297 298 310 311 322 324 326 327 342 357 372 373 374 379 381 382 384 385 390 391 392 401 404 416 421 426 431 435 438 461 462 464 465 467 468 471 473 487 513 514 520 533 538 540 542 543 549 551 552 564 573
NSCLC tumor 1.09e-08 38 26.573 1 2 5 6 7 10 11 12 19 23 24 33 34 36 38 41 44 45 46 52 55 58 60 66 68 72 75 76 84 88 89 90 92 93 94 100 104 107 108 109 112 113 118 121 122 129 130 131 137 139 142 148 153 154 164 165 167 168 172 176 180 181 190 191 194 203 204 209 210 213 220 222 223 230 234 235 242 262 263 275 290 297 298 310 322 324 326 327 342 357 372 373 374 379 382 384 385 392 401 404 426 428 431 435 438 461 462 464 465 467 468 469 471 486 487 514 520 533 542 543 551 552 564 573
Stage T1 all 1.12e-08 33 23.076 1 2 5 6 7 8 10 11 12 17 19 23 24 33 36 38 40 41 44 45 46 52 55 58 60 66 68 72 75 76 84 88 89 90 92 93 94 100 104 107 108 109 112 113 118 121 122 129 130 131 137 139 142 148 153 154 164 165 167 168 172 176 180 181 190 194 203 204 209 213 220 222 223 230 234 235 242 263 266 290 297 298 310 311 322 324 326 327 342 357 372 373 374 379 381 382 384 385 390 391 392 401 404 416 421 426 431 435 438 461 462 464 465 467 468 471 473 487 513 514 520 533 540 542 543 549 551 552 564 573
Stage T1 1.03e-07 27 18.881 1 2 5 6 7 8 10 11 12 17 19 23 24 33 34 36 38 40 41 44 45 46 52 54 55 58 60 66 68 72 75 76 84 88 89 90 92 93 94 100 104 107 108 109 112 113 118 119 121 122 129 130 131 137 139 142 143 148 153 154 164 165 167 168 171 172 176 180 181 191 194 203 204 209 213 220 222 223 230 234 235 242 262 263 290 297 298 309 310 311 322 324 326 327 342 357 372 373 374 379 381 382 384 385 390 391 401 404 416 421 426 431 435 438 461 462 464 465 467 468 473 487 513 514 520 533 538 540 542 543 549 551 552 564 573
Stage T1 - lung 1.03e-07 27 18.881 1 2 5 6 7 8 10 11 12 17 19 23 24 33 34 36 38 40 41 44 45 46 52 54 55 58 60 66 68 72 75 76 84 88 89 90 92 93 94 100 104 107 108 109 112 113 118 119 121 122 129 130 131 137 139 142 143 148 153 154 164 165 167 168 171 172 176 180 181 191 194 203 204 209 213 220 222 223 230 234 235 242 262 263 290 297 298 309 310 311 322 324 326 327 342 357 372 373 374 379 381 382 384 385 390 391 401 404 416 421 426 431 435 438 461 462 464 465 467 468 473 487 513 514 520 533 538 540 542 543 549 551 552 564 573
NSCLC tumor and cell line 1.25e-07 38 26.573 1 2 5 6 7 10 11 12 19 23 24 33 36 38 41 44 45 46 52 55 58 60 66 68 72 75 76 84 88 89 92 93 94 100 104 107 108 109 112 113 121 122 129 130 131 137 139 142 148 153 154 164 165 167 168 172 176 180 181 194 203 204 209 213 220 222 223 230 234 235 242 262 263 275 290 297 298 310 322 324 326 327 342 357 373 374 379 382 384 385 390 392 401 404 426 428 431 435 438 461 462 464 465 467 468 469 471 486 487 514 520 533 542 543 549 551 552 564 573
Lung cancer 4.96e-07 39 27.272 1 2 5 6 7 8 10 11 12 19 23 24 33 34 36 38 40 41 44 45 46 52 55 58 60 64 66 68 72 75 76 84 88 89 92 93 94 100 104 107 108 109 112 113 118 121 122 129 130 131 137 139 142 148 153 154 164 165 167 168 172 176 180 181 190 191 194 203 204 209 210 213 220 222 223 230 234 235 242 262 263 275 280 290 297 298 310 311 322 324 326 327 342 357 373 374 379 382 384 385 390 391 392 401 404 416 426 428 431 435 438 461 462 464 465 467 468 469 471 473 479 486 487 513 514 520 533 540 542 543 549 551 552 564 573
CNS tumor 5.20e-07 28 19.580 1 2 3 5 6 8 11 12 13 15 16 17 18 19 20 24 28 29 32 33 38 39 44 47 50 52 53 55 60 62 66 72 83 88 91 100 103 105 111 114 118 137 151 152 155 157 159 174 177 183 190 241 257 274 291 299 307 321 322 323 350 381 388 395 425 443 446 447 460 468 473 474 477 483 494 497 513 515 533 563 570
Chemo cytoxan 1.89e-06 15 10.489 1 2 3 5 6 8 11 12 15 17 18 19 28 32 38 44 47 50 52 60 62 66 72 83 88 91 100 105 111 114 118 137 151 152 155 157 159 190 257 307 321 323 443 446 460 468 474 494 497 515 570
AT/RT non-CNS 1.96e-06 5 3.496 28 32 50 81 83 91 102 103 111 113 114 149 151 155 157 159 245 274 299 386 425 446 447 468 483 497 570
CNS cancer or cell line 2.54e-06 28 19.580 1 2 3 5 6 8 11 12 13 15 16 17 18 19 24 28 29 32 33 38 44 47 50 52 53 55 60 62 66 72 83 84 88 91 100 103 105 111 114 118 137 151 152 155 157 159 174 177 183 190 241 257 274 291 299 307 321 322 323 350 381 395 425 443 446 447 460 468 473 474 477 483 497 515 533 563 570
CNS 2.57e-06 29 20.279 1 2 3 5 6 8 11 12 13 15 16 17 18 19 20 24 28 29 32 33 38 44 47 50 52 53 55 60 62 66 72 83 84 88 91 100 103 105 111 113 114 118 137 151 152 155 157 159 174 177 183 190 241 257 274 291 299 307 321 322 323 350 381 395 425 443 446 447 460 468 473 474 477 483 494 497 515 533 563 570
Lung cancer and cell line 3.38e-06 39 27.272 1 2 5 6 7 10 11 12 19 23 24 33 34 36 38 40 41 44 45 46 52 55 58 60 64 66 68 72 75 76 84 88 89 92 93 94 100 104 107 108 109 112 113 118 119 121 122 129 130 131 137 139 142 148 153 154 164 165 167 168 171 172 176 180 181 190 191 194 203 204 209 210 213 220 222 223 230 234 235 242 262 263 275 290 297 298 310 322 324 326 327 342 357 373 374 379 382 384 385 390 391 392 401 404 416 426 428 431 435 438 461 462 464 465 467 468 469 471 473 479 486 487 513 514 520 533 540 542 543 549 551 552 564 573
Chemo cisplatin 4.14e-06 15 10.489 1 2 3 5 6 8 11 12 17 18 19 20 28 32 38 44 47 50 52 60 62 66 72 83 88 91 100 105 111 114 118 137 151 152 155 157 159 177 190 257 307 321 323 443 446 460 468 474 494 497 515 570
DLBCL tissue 8.01e-06 25 17.482 33 37 47 60 69 70 76 79 84 97 118 120 128 136 138 145 169 170 171 174 175 179 182 188 201 204 208 210 211 214 237 238 241 255 258 261 291 292 300 301 317 329 345 348 358 361 378 387 398 399 436 449 456 459 466 468 512 513 522 525 532 562
Classic Medulloblastoma 1.24e-05 13 9.090 1 2 3 5 6 8 11 12 15 17 18 19 24 32 38 44 47 52 60 66 72 83 88 100 105 111 114 118 137 151 152 155 157 159 190 321 323 443 446 447 460 468 474 494 497 515 570
Liver tissue 1.26e-05 9 50 1 2 3 5 6 8 9 10 11 12 15 16 17 18 19 23 24 26 27 33 34 38 40 41 43 44 45 46 47 48 49 52 53 54 55 57 58 60 63 64 66 67 73 75 76 78 79 84 85 88 92 93 94 95 96 98 99 100 101 106 107 108 109 112 117 118 121 122 123 125 128 129 130 131 132 134 135 137 139 140 143 146 154 158 162 163 164 165 170 171 172 176 180 184 185 186 190 191 193 197 198 199 205 207 208 209 212 213 220 221 223 227 234 235 236 239 247 248 249 251 252 253 257 259 262 263 265 286 287 288 289 292 293 294 295 297 305 306 309 310 315 320 321 324 327 335 337 342 343 345 349 353 354 357 364 367 370 372 373 375 385 386 397 401 404 405 406 410 415 417 422 423 424 426 432 434 436 437 440 445 452 458 461 468 469 474 477 478 479 481 484 485 486 495 496 505 506 507 510 514 515 523 528 529 530 536 544 545 546 553 556 564 566
Chemo vincristine 1.34e-05 15 10.489 1 2 3 5 6 8 11 12 17 18 19 20 24 28 32 38 44 47 50 52 60 62 66 72 83 88 91 100 105 111 114 118 137 151 152 155 157 159 177 190 257 307 321 323 443 446 447 460 468 474 494 497 515 570
HBV infected 1.84e-05 8 44.444 1 2 5 6 8 9 10 11 12 15 17 18 19 23 24 27 33 34 38 40 41 43 44 45 46 47 48 49 52 53 54 55 57 58 60 63 64 66 67 73 75 76 78 84 85 88 92 93 94 95 96 98 99 100 101 106 107 108 109 112 117 118 121 123 125 129 130 131 132 134 135 137 140 144 146 154 158 163 164 165 172 176 180 184 185 190 191 193 197 198 199 205 207 209 212 213 221 223 227 234 235 239 247 248 249 251 252 257 259 262 263 265 276 286 287 288 289 292 293 294 295 297 305 306 309 310 319 320 324 327 337 342 343 345 349 353 354 357 364 367 370 372 373 375 385 386 397 401 404 406 410 415 417 422 423 424 426 432 434 436 440 445 452 458 461 468 469 474 477 478 479 481 485 486 495 496 505 506 507 510 514 515 523 529 530 536 544 545 546 553 566
Liver tissue or cell line 1.94e-05 9 50 1 2 3 5 6 8 9 10 11 12 15 16 17 18 19 23 24 27 33 34 38 40 41 43 44 45 46 47 48 49 52 53 54 55 57 58 60 63 64 66 67 72 73 75 76 78 79 84 85 88 92 93 94 95 96 98 99 100 101 106 107 108 109 112 117 118 121 122 123 125 128 129 130 131 132 134 135 137 139 140 146 154 158 162 163 164 165 170 171 172 176 180 184 185 186 190 191 193 197 198 199 205 207 208 209 212 213 220 221 223 227 234 235 236 239 247 248 249 250 251 252 253 257 259 262 263 265 283 286 287 288 289 292 293 294 295 297 305 306 309 310 315 320 321 324 327 335 337 342 343 345 349 353 354 357 364 367 370 372 373 375 385 386 397 401 402 404 405 406 410 415 417 422 423 424 426 432 434 436 437 440 445 452 454 457 458 461 468 469 474 477 478 479 481 484 486 495 496 505 506 507 510 514 515 523 528 529 530 536 544 545 546 553 556 564 566
DLBCL tissue and cell line 2.28e-05 25 17.482 33 37 47 52 61 69 70 76 79 84 97 118 120 128 136 138 145 169 170 174 175 179 182 188 201 204 208 210 211 214 237 238 241 255 258 261 291 292 300 301 317 329 345 348 358 361 378 387 398 399 436 449 456 459 466 468 512 513 522 525 532 562
Hepatitis infected 3.02e-05 8 44.444 1 2 5 6 8 9 10 11 12 15 17 19 23 24 27 33 34 38 40 41 43 44 45 46 47 48 49 52 53 54 55 57 58 60 63 64 66 67 73 75 76 78 79 84 85 88 92 93 94 95 96 98 99 100 101 106 107 108 109 112 117 118 121 123 125 128 129 130 131 132 134 135 137 140 144 146 154 158 163 164 165 170 171 172 176 180 184 185 190 191 193 197 198 199 205 207 208 209 212 213 221 223 227 234 235 239 247 248 249 251 252 257 259 262 263 265 276 286 287 288 289 292 293 294 295 297 305 306 309 310 319 320 324 327 337 342 343 345 349 353 354 357 364 367 370 372 373 375 385 386 397 401 404 406 410 415 417 422 423 424 426 434 436 440 445 452 458 461 468 469 474 477 478 479 481 485 486 495 496 505 506 507 510 514 515 523 529 530 536 544 545 546 553 564 566
Liver non-tumor 3.62e-05 6 33.333 1 2 5 6 8 9 10 11 12 15 18 19 23 24 26 27 33 34 38 40 41 43 44 45 46 47 48 49 53 54 55 57 58 60 63 64 66 73 75 76 78 79 84 85 88 92 93 94 95 96 98 99 100 101 106 107 108 109 112 117 118 121 122 123 124 125 128 129 130 131 132 134 135 137 140 146 154 158 162 163 164 165 170 171 172 176 180 184 185 190 191 193 197 198 199 205 207 208 209 212 213 220 221 223 225 227 234 235 236 238 239 241 244 247 248 249 252 253 257 259 262 263 265 276 283 286 287 288 289 292 294 295 297 301 302 305 306 309 310 315 319 320 321 324 327 335 337 342 343 345 349 353 354 357 364 370 372 373 375 385 397 401 403 404 405 410 415 417 422 423 424 426 431 434 436 437 440 445 452 456 458 461 468 469 470 474 478 479 481 484 485 486 494 495 496 505 506 521 523 528 529 536 544 545 546 556 566
Lymphoma tissue or cell line 3.84e-05 29 20.279 33 37 61 69 70 79 97 118 120 128 136 138 145 169 170 174 175 179 182 188 201 204 214 237 238 241 255 258 261 278 291 292 301 317 329 345 348 358 361 378 387 398 399 436 456 459 468 512 513 525 532 562
Medulloblastoma 5.55e-05 15 10.489 1 2 3 5 6 8 11 12 15 17 18 19 20 24 28 29 32 38 44 47 50 52 55 60 62 66 72 83 88 91 100 103 105 111 114 118 137 151 152 155 157 159 174 177 190 257 299 307 321 323 443 446 447 460 468 474 494 497 515 570
Lung 5.69e-05 40 27.972 1 2 5 6 7 8 10 11 12 17 19 21 23 24 33 34 36 38 40 41 44 45 46 52 55 56 58 60 66 68 72 75 76 84 88 89 90 92 93 94 100 104 105 107 108 109 112 113 118 119 121 122 127 129 130 131 137 139 142 148 153 154 164 165 167 168 172 176 180 181 189 190 191 194 203 204 209 210 213 220 222 223 230 234 235 242 262 263 275 290 297 298 310 311 322 324 326 327 342 357 373 374 376 379 382 384 385 390 391 392 401 404 416 421 426 428 431 435 438 450 461 462 464 465 467 468 469 471 473 479 486 487 513 514 520 533 538 540 542 543 549 551 552 556 564 573
AT/RT CNS 0.00012 4 2.797 111 113 157 274 386 446 468 497 565 570
Dead - B lymphoma 0.00014 13 9.090 33 37 69 70 76 79 84 97 118 120 128 136 138 145 169 170 174 175 179 182 188 201 204 208 210 214 237 238 241 255 258 261 291 292 300 301 317 329 345 348 358 361 378 387 436 459 468 512 513 522 525 532 562
CNS tumor 0.00016 7 38.888 1 2 3 5 6 8 11 12 13 15 16 17 18 19 20 24 28 29 32 33 38 39 44 47 50 52 53 55 60 62 66 72 83 88 91 100 103 105 111 114 118 137 151 152 155 157 159 174 177 183 190 241 257 274 291 299 307 321 322 323 350 381 388 395 425 443 446 447 460 468 473 474 477 483 494 497 513 515 533 563 570
Medulloblastoma 0.00024 5 27.777 1 2 3 5 6 8 11 12 15 17 18 19 20 24 28 29 32 38 44 47 50 52 55 60 62 66 72 83 88 91 100 103 105 111 114 118 137 151 152 155 157 159 174 177 190 257 299 307 321 323 443 446 447 460 468 474 494 497 515 570
CNS cancer or cell line 0.00025 7 38.888 1 2 3 5 6 8 11 12 13 15 16 17 18 19 24 28 29 32 33 38 44 47 50 52 53 55 60 62 66 72 83 84 88 91 100 103 105 111 114 118 137 151 152 155 157 159 174 177 183 190 241 257 274 291 299 307 321 322 323 350 381 395 425 443 446 447 460 468 473 474 477 483 497 515 533 563 570
CNS 0.00037 7 38.888 1 2 3 5 6 8 11 12 13 15 16 17 18 19 20 24 28 29 32 33 38 44 47 50 52 53 55 60 62 66 72 83 84 88 91 100 103 105 111 113 114 118 137 151 152 155 157 159 174 177 183 190 241 257 274 291 299 307 321 322 323 350 381 395 425 443 446 447 460 468 473 474 477 483 494 497 515 533 563 570


Jump to: General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Enriched GO annotations
For each GO annotation, we tested whether it was enriched in the set of genes of the module. Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of genes in which they appear. We also show the fraction of genes with the given GO annotation that are included in this module ('Hits (%)' column).


Jump to: General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Visual display
Below is a visual display of the module. Shown are those arrays in which the module's genes significantly change, and the direction of change (induction/repression) in each array is indicated (middle, labeled 'Module changes'; red/green row). The arrays that correspond to the significant clinical attributes are also shown (top; brown rows). The gene sets that compose the module are also shown (left) along with an indication of the membership of the module genes in these gene sets.
You can also view the images within GeneXPress by loading the module gxp file file.
 
 





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